ID   MZRA_PANAA              Reviewed;         115 AA.
AC   F2EUZ7;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Modulator protein MzrA {ECO:0000255|HAMAP-Rule:MF_00904};
GN   Name=mzrA {ECO:0000255|HAMAP-Rule:MF_00904}; OrderedLocusNames=PAJ_2693;
OS   Pantoea ananatis (strain AJ13355).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Pantoea.
OX   NCBI_TaxID=932677;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AJ13355;
RX   PubMed=22159605; DOI=10.1007/s00253-011-3713-5;
RA   Hara Y., Kadotani N., Izui H., Katashkina J.I., Kuvaeva T.M.,
RA   Andreeva I.G., Golubeva L.I., Malko D.B., Makeev V.J., Mashko S.V.,
RA   Kozlov Y.I.;
RT   "The complete genome sequence of Pantoea ananatis AJ13355, an organism with
RT   great biotechnological potential.";
RL   Appl. Microbiol. Biotechnol. 93:331-341(2012).
CC   -!- FUNCTION: Modulates the activity of the EnvZ/OmpR two-component
CC       regulatory system, probably by directly modulating EnvZ enzymatic
CC       activity and increasing stability of phosphorylated OmpR.
CC       {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBUNIT: Interacts with EnvZ. {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00904}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
CC   -!- SIMILARITY: Belongs to the MzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
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DR   EMBL; AP012032; BAK12773.1; -; Genomic_DNA.
DR   RefSeq; WP_014594689.1; NC_017531.2.
DR   AlphaFoldDB; F2EUZ7; -.
DR   SMR; F2EUZ7; -.
DR   STRING; 932677.PAJ_2693; -.
DR   EnsemblBacteria; BAK12773; BAK12773; PAJ_2693.
DR   KEGG; paj:PAJ_2693; -.
DR   PATRIC; fig|932677.3.peg.3148; -.
DR   eggNOG; ENOG503386H; Bacteria.
DR   HOGENOM; CLU_153761_1_0_6; -.
DR   OMA; WHHLDAN; -.
DR   BioCyc; PANA932677:PAJ_RS15005-MON; -.
DR   Proteomes; UP000006690; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019901; F:protein kinase binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00904; Modulator_MzrA; 1.
DR   InterPro; IPR026574; Modulator_MzrA.
DR   InterPro; IPR027398; SecD-TM.
DR   Pfam; PF13721; SecD-TM1; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..115
FT                   /note="Modulator protein MzrA"
FT                   /id="PRO_0000413190"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TOPO_DOM        32..115
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
SQ   SEQUENCE   115 AA;  12764 MW;  4FBDD321C6B71218 CRC64;
     MKPLHAFPKR WLPWLIGGAF ALVAISMMPS LMRHENVVQI RVSHAGAPMP DGFYLYQQLS
     AQGIRIKSIT PSGDALIIHF DNEEQSLAAQ KVLRRLLPDG FIVAQHDQAA HLSLA