ID   MZRA_PANSA              Reviewed;         122 AA.
AC   E6WE99;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Modulator protein MzrA {ECO:0000255|HAMAP-Rule:MF_00904};
GN   Name=mzrA {ECO:0000255|HAMAP-Rule:MF_00904}; OrderedLocusNames=Pat9b_3497;
OS   Pantoea sp. (strain At-9b).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Pantoea; unclassified Pantoea.
OX   NCBI_TaxID=592316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=At-9b;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Ovchinnikova G., Pinto A., Currie C., Woyke T.;
RT   "Complete sequence chromosome of Pantoea sp. At-9b.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates the activity of the EnvZ/OmpR two-component
CC       regulatory system, probably by directly modulating EnvZ enzymatic
CC       activity and increasing stability of phosphorylated OmpR.
CC       {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBUNIT: Interacts with EnvZ. {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00904}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
CC   -!- SIMILARITY: Belongs to the MzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
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DR   EMBL; CP002433; ADU70787.1; -; Genomic_DNA.
DR   RefSeq; WP_013510638.1; NC_014837.1.
DR   AlphaFoldDB; E6WE99; -.
DR   SMR; E6WE99; -.
DR   STRING; 592316.Pat9b_3497; -.
DR   EnsemblBacteria; ADU70787; ADU70787; Pat9b_3497.
DR   KEGG; pao:Pat9b_3497; -.
DR   eggNOG; ENOG503386H; Bacteria.
DR   HOGENOM; CLU_153761_1_0_6; -.
DR   OMA; WHHLDAN; -.
DR   OrthoDB; 1713717at2; -.
DR   Proteomes; UP000001624; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019901; F:protein kinase binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00904; Modulator_MzrA; 1.
DR   InterPro; IPR026574; Modulator_MzrA.
DR   InterPro; IPR027398; SecD-TM.
DR   Pfam; PF13721; SecD-TM1; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..122
FT                   /note="Modulator protein MzrA"
FT                   /id="PRO_0000413191"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TOPO_DOM        32..122
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
SQ   SEQUENCE   122 AA;  13300 MW;  7B244789C448140D CRC64;
     MKILTRIPRR LLPWLLGGAL ALVAVSFAPA LLSHETVVQI RVANSGTPLP DGFYLYQQLS
     AQGVRIKSIT PSGDALVIHF ENEEQSLAAQ KVLRRLLPQG FVVAAGHQAS QQNQDANRSI
     YS