ID   MZRA_PECCP              Reviewed;         131 AA.
AC   C6DKE3;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Modulator protein MzrA {ECO:0000255|HAMAP-Rule:MF_00904};
GN   Name=mzrA {ECO:0000255|HAMAP-Rule:MF_00904}; OrderedLocusNames=PC1_0525;
OS   Pectobacterium carotovorum subsp. carotovorum (strain PC1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=561230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PC1;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C.,
RA   Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Balakrishnan V., Glasner J., Perna N.T.;
RT   "Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates the activity of the EnvZ/OmpR two-component
CC       regulatory system, probably by directly modulating EnvZ enzymatic
CC       activity and increasing stability of phosphorylated OmpR.
CC       {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBUNIT: Interacts with EnvZ. {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00904}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
CC   -!- SIMILARITY: Belongs to the MzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
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DR   EMBL; CP001657; ACT11580.1; -; Genomic_DNA.
DR   RefSeq; WP_012773232.1; NC_012917.1.
DR   AlphaFoldDB; C6DKE3; -.
DR   SMR; C6DKE3; -.
DR   STRING; 561230.PC1_0525; -.
DR   EnsemblBacteria; ACT11580; ACT11580; PC1_0525.
DR   KEGG; pct:PC1_0525; -.
DR   eggNOG; ENOG50333DY; Bacteria.
DR   HOGENOM; CLU_153761_1_0_6; -.
DR   OMA; WHHLDAN; -.
DR   OrthoDB; 1704218at2; -.
DR   Proteomes; UP000002736; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019901; F:protein kinase binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00904; Modulator_MzrA; 1.
DR   InterPro; IPR026574; Modulator_MzrA.
DR   InterPro; IPR027398; SecD-TM.
DR   Pfam; PF13721; SecD-TM1; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..131
FT                   /note="Modulator protein MzrA"
FT                   /id="PRO_0000413192"
FT   TOPO_DOM        1..14
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TRANSMEM        15..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TOPO_DOM        32..131
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
SQ   SEQUENCE   131 AA;  14714 MW;  29C11FB776A96844 CRC64;
     MSIRWLFPKL TPRKVARILI LLALPIIALT QSQSLRHSQD DAMLHIKPYD GAALPDGFYV
     YQRLNEKGIA IKSITPEQDS LIVRLASPEQ SIAARDVLRL SLPKVTITAQ QATTPTPFWQ
     QKLTQKQSKL G