ID   MZRA_SALA4              Reviewed;         127 AA.
AC   B5F6N4;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Modulator protein MzrA {ECO:0000255|HAMAP-Rule:MF_00904};
GN   Name=mzrA {ECO:0000255|HAMAP-Rule:MF_00904}; OrderedLocusNames=SeAg_B3415;
OS   Salmonella agona (strain SL483).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=454166;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL483;
RX   PubMed=21602358; DOI=10.1128/jb.00297-11;
RA   Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA   Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT   CRISPR-mediated adaptive sublineage evolution.";
RL   J. Bacteriol. 193:3556-3568(2011).
CC   -!- FUNCTION: Modulates the activity of the EnvZ/OmpR two-component
CC       regulatory system, probably by directly modulating EnvZ enzymatic
CC       activity and increasing stability of phosphorylated OmpR.
CC       {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBUNIT: Interacts with EnvZ. {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00904}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
CC   -!- SIMILARITY: Belongs to the MzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ACH50615.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP001138; ACH50615.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000917514.1; NC_011149.1.
DR   AlphaFoldDB; B5F6N4; -.
DR   SMR; B5F6N4; -.
DR   EnsemblBacteria; ACH50615; ACH50615; SeAg_B3415.
DR   KEGG; sea:SeAg_B3415; -.
DR   HOGENOM; CLU_153761_0_0_6; -.
DR   Proteomes; UP000008819; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019901; F:protein kinase binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00904; Modulator_MzrA; 1.
DR   InterPro; IPR026574; Modulator_MzrA.
DR   InterPro; IPR027398; SecD-TM.
DR   Pfam; PF13721; SecD-TM1; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..127
FT                   /note="Modulator protein MzrA"
FT                   /id="PRO_0000413194"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TOPO_DOM        32..127
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
SQ   SEQUENCE   127 AA;  14290 MW;  ED16063337D64EDA CRC64;
     MLKPRITARQ LIWISAFLLM LTILMMTWST LRQQESTLAI RAVNLGASMP DGFSVLHHLD
     ANGIHFKSIT PKNDMLLITF DSPAQSAAAK TVLDQTLPHG YVVAQQDDDN ETVQWLSRLR
     ESSHRFG