MZT1_MOUSE
ID MZT1_MOUSE Reviewed; 78 AA.
AC Q8BUR9;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Mitotic-spindle organizing protein 1;
DE AltName: Full=Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1;
GN Name=Mzt1; Synonyms=Mozart1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, DBA/2J, and NOD; TISSUE=Bone marrow, Kidney, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH TUBG1.
RX PubMed=20360068; DOI=10.1126/science.1181348;
RA Hutchins J.R., Toyoda Y., Hegemann B., Poser I., Heriche J.K., Sykora M.M.,
RA Augsburg M., Hudecz O., Buschhorn B.A., Bulkescher J., Conrad C.,
RA Comartin D., Schleiffer A., Sarov M., Pozniakovsky A., Slabicki M.M.,
RA Schloissnig S., Steinmacher I., Leuschner M., Ssykor A., Lawo S.,
RA Pelletier L., Stark H., Nasmyth K., Ellenberg J., Durbin R., Buchholz F.,
RA Mechtler K., Hyman A.A., Peters J.M.;
RT "Systematic analysis of human protein complexes identifies chromosome
RT segregation proteins.";
RL Science 328:593-599(2010).
CC -!- FUNCTION: Required for gamma-tubulin complex recruitment to the
CC centrosome. {ECO:0000269|PubMed:20360068}.
CC -!- SUBUNIT: Part of the gamma-tubulin complex. Interacts with TUBG1.
CC {ECO:0000269|PubMed:20360068}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000269|PubMed:20360068}. Cytoplasm,
CC cytoskeleton, spindle {ECO:0000269|PubMed:20360068}.
CC -!- SIMILARITY: Belongs to the MOZART1 family. {ECO:0000305}.
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DR EMBL; AK082817; BAC38633.1; -; mRNA.
DR EMBL; AK150268; BAE29424.1; -; mRNA.
DR EMBL; AK151232; BAE30224.1; -; mRNA.
DR EMBL; AK151358; BAE30333.1; -; mRNA.
DR EMBL; AK151819; BAE30716.1; -; mRNA.
DR EMBL; AK160911; BAE36085.1; -; mRNA.
DR EMBL; AK165605; BAE38289.1; -; mRNA.
DR EMBL; AK168114; BAE40085.1; -; mRNA.
DR EMBL; AK169036; BAE40827.1; -; mRNA.
DR EMBL; AK170746; BAE41999.1; -; mRNA.
DR EMBL; BC117005; AAI17006.1; -; mRNA.
DR EMBL; BC117007; AAI17008.1; -; mRNA.
DR CCDS; CCDS49554.1; -.
DR RefSeq; NP_780454.1; NM_175245.4.
DR AlphaFoldDB; Q8BUR9; -.
DR SMR; Q8BUR9; -.
DR BioGRID; 218316; 12.
DR IntAct; Q8BUR9; 11.
DR MINT; Q8BUR9; -.
DR STRING; 10090.ENSMUSP00000037557; -.
DR PhosphoSitePlus; Q8BUR9; -.
DR EPD; Q8BUR9; -.
DR MaxQB; Q8BUR9; -.
DR PaxDb; Q8BUR9; -.
DR PeptideAtlas; Q8BUR9; -.
DR PRIDE; Q8BUR9; -.
DR ProteomicsDB; 287343; -.
DR Antibodypedia; 71297; 31 antibodies from 12 providers.
DR DNASU; 76789; -.
DR Ensembl; ENSMUST00000042662; ENSMUSP00000037557; ENSMUSG00000033186.
DR GeneID; 76789; -.
DR KEGG; mmu:76789; -.
DR UCSC; uc007uuu.2; mouse.
DR CTD; 440145; -.
DR MGI; MGI:1924039; Mzt1.
DR VEuPathDB; HostDB:ENSMUSG00000033186; -.
DR eggNOG; ENOG502S6UI; Eukaryota.
DR GeneTree; ENSGT00390000005954; -.
DR HOGENOM; CLU_160285_0_0_1; -.
DR InParanoid; Q8BUR9; -.
DR OMA; LSICVGM; -.
DR OrthoDB; 1645115at2759; -.
DR PhylomeDB; Q8BUR9; -.
DR TreeFam; TF328444; -.
DR Reactome; R-MMU-380270; Recruitment of mitotic centrosome proteins and complexes.
DR Reactome; R-MMU-380320; Recruitment of NuMA to mitotic centrosomes.
DR BioGRID-ORCS; 76789; 12 hits in 70 CRISPR screens.
DR ChiTaRS; Mzt1; mouse.
DR PRO; PR:Q8BUR9; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8BUR9; protein.
DR Bgee; ENSMUSG00000033186; Expressed in manus and 224 other tissues.
DR ExpressionAtlas; Q8BUR9; baseline and differential.
DR Genevisible; Q8BUR9; MM.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000931; C:gamma-tubulin large complex; ISS:UniProtKB.
DR GO; GO:0031021; C:interphase microtubule organizing center; IBA:GO_Central.
DR GO; GO:0005819; C:spindle; ISS:UniProtKB.
DR GO; GO:0033566; P:gamma-tubulin complex localization; ISS:UniProtKB.
DR GO; GO:0051415; P:microtubule nucleation by interphase microtubule organizing center; IBA:GO_Central.
DR GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR InterPro; IPR022214; MZT1.
DR PANTHER; PTHR28520; PTHR28520; 1.
DR Pfam; PF12554; MOZART1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Cytoskeleton; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q08AG7"
FT CHAIN 2..78
FT /note="Mitotic-spindle organizing protein 1"
FT /id="PRO_0000337016"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q08AG7"
SQ SEQUENCE 78 AA; 8132 MW; 3F1B1C22599725D9 CRC64;
MASGSGPGAA ASANLNAVRE TMDVLLEISR ILNTGLDMET LSICVRLCEQ GINPEALSSV
IKELRKGTEA LKAAENTS
