MZT2A_HUMAN
ID MZT2A_HUMAN Reviewed; 158 AA.
AC Q6P582; Q3SWV8; Q8WVB2;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Mitotic-spindle organizing protein 2A;
DE AltName: Full=Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A;
GN Name=MZT2A; Synonyms=FAM128A, MOZART2A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION IN THE GAMMA-TUBULIN COMPLEX.
RX PubMed=20360068; DOI=10.1126/science.1181348;
RA Hutchins J.R., Toyoda Y., Hegemann B., Poser I., Heriche J.K., Sykora M.M.,
RA Augsburg M., Hudecz O., Buschhorn B.A., Bulkescher J., Conrad C.,
RA Comartin D., Schleiffer A., Sarov M., Pozniakovsky A., Slabicki M.M.,
RA Schloissnig S., Steinmacher I., Leuschner M., Ssykor A., Lawo S.,
RA Pelletier L., Stark H., Nasmyth K., Ellenberg J., Durbin R., Buchholz F.,
RA Mechtler K., Hyman A.A., Peters J.M.;
RT "Systematic analysis of human protein complexes identifies chromosome
RT segregation proteins.";
RL Science 328:593-599(2010).
CC -!- SUBUNIT: Part of the gamma-tubulin complex.
CC {ECO:0000269|PubMed:20360068}.
CC -!- INTERACTION:
CC Q6P582; O00571: DDX3X; NbExp=3; IntAct=EBI-2558548, EBI-353779;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome. Cytoplasm, cytoskeleton, spindle.
CC -!- SIMILARITY: Belongs to the MOZART2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAX93252.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC073869; AAX93252.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC018206; AAH18206.2; -; mRNA.
DR EMBL; BC063024; AAH63024.1; -; mRNA.
DR EMBL; BC104650; AAI04651.1; -; mRNA.
DR CCDS; CCDS42758.1; -.
DR RefSeq; NP_001078834.1; NM_001085365.1.
DR PDB; 6X0V; EM; 4.50 A; E=1-158.
DR PDBsum; 6X0V; -.
DR AlphaFoldDB; Q6P582; -.
DR SMR; Q6P582; -.
DR BioGRID; 576069; 32.
DR IntAct; Q6P582; 30.
DR STRING; 9606.ENSP00000311500; -.
DR iPTMnet; Q6P582; -.
DR PhosphoSitePlus; Q6P582; -.
DR BioMuta; MZT2A; -.
DR DMDM; 190359337; -.
DR EPD; Q6P582; -.
DR jPOST; Q6P582; -.
DR MassIVE; Q6P582; -.
DR MaxQB; Q6P582; -.
DR PaxDb; Q6P582; -.
DR PeptideAtlas; Q6P582; -.
DR PRIDE; Q6P582; -.
DR ProteomicsDB; 66991; -.
DR Antibodypedia; 71848; 4 antibodies from 4 providers.
DR DNASU; 653784; -.
DR Ensembl; ENST00000309451.7; ENSP00000311500.6; ENSG00000173272.16.
DR GeneID; 653784; -.
DR KEGG; hsa:653784; -.
DR MANE-Select; ENST00000309451.7; ENSP00000311500.6; NM_001085365.2; NP_001078834.1.
DR UCSC; uc002tsw.5; human.
DR CTD; 653784; -.
DR DisGeNET; 653784; -.
DR GeneCards; MZT2A; -.
DR HGNC; HGNC:33187; MZT2A.
DR HPA; ENSG00000173272; Low tissue specificity.
DR MalaCards; MZT2A; -.
DR MIM; 613449; gene.
DR neXtProt; NX_Q6P582; -.
DR OpenTargets; ENSG00000173272; -.
DR PharmGKB; PA165696923; -.
DR VEuPathDB; HostDB:ENSG00000173272; -.
DR eggNOG; ENOG502S50R; Eukaryota.
DR GeneTree; ENSGT00390000014845; -.
DR HOGENOM; CLU_105461_0_0_1; -.
DR InParanoid; Q6P582; -.
DR OMA; PPAGALX; -.
DR OrthoDB; 1453946at2759; -.
DR PhylomeDB; Q6P582; -.
DR TreeFam; TF333013; -.
DR PathwayCommons; Q6P582; -.
DR Reactome; R-HSA-380270; Recruitment of mitotic centrosome proteins and complexes.
DR Reactome; R-HSA-380320; Recruitment of NuMA to mitotic centrosomes.
DR SignaLink; Q6P582; -.
DR BioGRID-ORCS; 653784; 41 hits in 1004 CRISPR screens.
DR ChiTaRS; MZT2A; human.
DR GenomeRNAi; 653784; -.
DR Pharos; Q6P582; Tdark.
DR PRO; PR:Q6P582; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q6P582; protein.
DR Bgee; ENSG00000173272; Expressed in parotid gland and 199 other tissues.
DR ExpressionAtlas; Q6P582; baseline and differential.
DR Genevisible; Q6P582; HS.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0000931; C:gamma-tubulin large complex; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005819; C:spindle; ISS:UniProtKB.
DR InterPro; IPR024332; MOZART2.
DR PANTHER; PTHR28578; PTHR28578; 1.
DR Pfam; PF12926; MOZART2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..158
FT /note="Mitotic-spindle organizing protein 2A"
FT /id="PRO_0000338987"
FT REGION 84..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 34
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6NZ67"
FT MOD_RES 152
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6NZ67"
FT CONFLICT 36..57
FT /note="EEMELYELAQAAGGGIDPDVFK -> LQGGGRAGRRGLTGPASVPAR (in
FT Ref. 2; AAI04651)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 158 AA; 16221 MW; B0B90630AE086B75 CRC64;
MAAQGVGPGP GSAAPPGLEA ARQKLALRRK KVLSTEEMEL YELAQAAGGG IDPDVFKILV
DLLKLNVAPL AVFQMLKSMC AGQRLASEPQ DPAAVSLPTS SVPETRGRDK GSAALGGVLA
LAERSNHEGS SQRMPRQPSA TRLPKGGGPG KSPTQGST
