ID   M_PRRSS                 Reviewed;         173 AA.
AC   A0MD35;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   23-FEB-2022, entry version 27.
DE   RecName: Full=Membrane protein;
DE            Short=Protein M;
GN   Name=M; ORFNames=6;
OS   Porcine reproductive and respiratory syndrome virus (isolate Pig/United
OS   States/SD 01-08/2001) (PRRSV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Arnidovirineae; Arteriviridae; unclassified Arteriviridae.
OX   NCBI_TaxID=857306;
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Infectious clone SD 01-08;
RX   PubMed=17037606; DOI=10.1007/978-0-387-33012-9_110;
RA   Fang Y., Faaberg K.S., Rowland R.R., Christopher-Hennings J.,
RA   Pattnaik A.K., Osorio F., Nelson E.A.;
RT   "Construction of a full-length cDNA infectious clone of a European-like
RT   Type 1 PRRSV isolated in the U.S.";
RL   Adv. Exp. Med. Biol. 581:605-608(2006).
CC   -!- FUNCTION: Major envelope protein. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with glycoprotein 5; disulfide-linked. This
CC       heterodimerization is required for transport to the Golgi complex.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}. Host membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the arteriviridae membrane protein family.
CC       {ECO:0000305}.
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DR   EMBL; DQ489311; ABF66347.1; -; Genomic_RNA.
DR   Proteomes; UP000000937; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001332; Arteri_GP5.
DR   Pfam; PF00951; Arteri_Gl; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Host membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Viral envelope protein; Virion.
FT   CHAIN           1..173
FT                   /note="Membrane protein"
FT                   /id="PRO_0000410888"
FT   TOPO_DOM        1..12
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        34..39
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..69
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        91..173
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   DISULFID        8
FT                   /note="Interchain (with C-24 in GP5)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   173 AA;  18910 MW;  B69A44B9451F3BC1 CRC64;
     MGGLDNFCND PTAAQKIVLA FSITYTPIMI YALKVSRGRL LGLLHILIFL NCSFTFGYMT
     YVHFHSTHRV ALTLGAVVAL LWGVYSLTES WKFITSRCRL CCLGRRYILA PAHHVESAAG
     LHSISASGNR AYAVRKPGLT SVNGTLVPGL RSLVLGGKRA VKRGVVNLVK YGR