ID   N1_VAR67                Reviewed;         117 AA.
AC   P34018;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Protein N1;
GN   ORFNames=N1L, P1L, R1L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967 / Isolate Ind3;
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Garcia-1966;
RA   Massung R.F., Loparev V.N., Knight J.C., Chizhikov V.E., Parsons J.M.,
RA   Totmenin A.V., Shchelkunov S.N., Esposito J.J.;
RL   Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bcl-2-like protein which contributes to virulence by
CC       preventing host NF-kappa-B activation in response to pro-inflammatory
CC       stimuli such as TNF-alpha or IL1B. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae N1 protein family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X69198; CAA48957.1; -; Genomic_DNA.
DR   EMBL; U18338; AAA69362.1; -; Genomic_DNA.
DR   PIR; F36838; F36838.
DR   PIR; F72152; F72152.
DR   RefSeq; NP_042060.1; NC_001611.1.
DR   SMR; P34018; -.
DR   PRIDE; P34018; -.
DR   GeneID; 1486481; -.
DR   KEGG; vg:1486481; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.437.20; -; 1.
DR   InterPro; IPR009353; Orthopox_N1.
DR   InterPro; IPR022819; Poxvirus_Bcl-2-like.
DR   InterPro; IPR043018; Poxvirus_sf.
DR   Pfam; PF06227; Poxvirus; 1.
DR   PIRSF; PIRSF003784; VAC_N1L; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction;
KW   Inhibition of host NF-kappa-B by virus;
KW   Modulation of host cell apoptosis by virus; Reference proteome;
KW   Viral immunoevasion.
FT   CHAIN           1..117
FT                   /note="Protein N1"
FT                   /id="PRO_0000099634"
SQ   SEQUENCE   117 AA;  13915 MW;  182A9176DF2B391A CRC64;
     MRTLLIRYIL WRNDGDPSYY NDDFEKLMLL DELVDDSDVC TLIKNMRMTL SDGPLLDRLN
     QPVNNVEDVK RMIAISAKVA RDIGERPEIR WEESFTILFR MIETYFDDLM IDLYGEK