ID   N2C1A_XENLA             Reviewed;         637 AA.
AC   Q6GN21; O42177;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Nuclear receptor subfamily 2 group C member 1-A;
DE   AltName: Full=Developmental orphan receptor 2-A;
DE            Short=DOR2-A;
DE            Short=xDOR2-A;
DE   AltName: Full=Orphan nuclear receptor TR2-A;
DE   AltName: Full=Testicular receptor 2-A;
GN   Name=nr2c1-a; Synonyms=dor2 {ECO:0000312|EMBL:AAH73700.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH73700.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte {ECO:0000312|EMBL:AAH73700.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305, ECO:0000312|EMBL:AAB81178.1}
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 28-569, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Neurula {ECO:0000269|PubMed:10520740};
RX   PubMed=10520740; DOI=10.3109/10425179809086435;
RA   Huard V., Seguin C.;
RT   "Cloning of a cDNA for xDOR2, a novel TR2-related nuclear orphan receptor,
RT   expressed during neurulation in Xenopus laevis embryos.";
RL   DNA Seq. 9:113-120(1998).
CC   -!- FUNCTION: Orphan nuclear receptor. Binds the IR7 element in the
CC       promoter of its own gene in an autoregulatory negative feedback
CC       mechanism. Primarily repressor of a broad range of genes. Binds to
CC       hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half
CC       site direct repeat consensus sequences (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at a low level in neurula stage embryos.
CC       {ECO:0000269|PubMed:10520740}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC       subfamily. {ECO:0000255}.
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DR   EMBL; BC073700; AAH73700.1; -; mRNA.
DR   EMBL; AF013295; AAB81178.1; -; mRNA.
DR   RefSeq; NP_001084198.1; NM_001090729.1.
DR   AlphaFoldDB; Q6GN21; -.
DR   DNASU; 399361; -.
DR   GeneID; 399361; -.
DR   KEGG; xla:399361; -.
DR   CTD; 399361; -.
DR   Xenbase; XB-GENE-6254030; nr2c1.S.
DR   OrthoDB; 278171at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 399361; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..637
FT                   /note="Nuclear receptor subfamily 2 group C member 1-A"
FT                   /id="PRO_0000287912"
FT   DOMAIN          383..624
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        149..224
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         152..172
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         188..207
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   CONFLICT        28..33
FT                   /note="QTALMD -> PLLFVN (in Ref. 2; AAB81178)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        346
FT                   /note="L -> P (in Ref. 2; AAB81178)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        567..569
FT                   /note="QDY -> HGI (in Ref. 2; AAB81178)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   637 AA;  70785 MW;  FB0BCA73E57A8E62 CRC64;
     MASIEEIAHQ IIEQQMGEIS RSQTEVSQTA LMDGTTQRIQ LVPSESNVSV PQRIQIVTDP
     QTGQKIQIVT ALDQSGVSKQ FILTNNDGSL PSKVILARQD SNQGKVFLTT PDAAGMNQLF
     FSSPDVPAQH IQILSDTQSL DQNLNKQLVE LCVVCGDKAS GRHYGAVTCE GCKGFFKRSI
     RKNLVYTCRG SKDCVINKHY RNRCQYCRLQ RCMSLGMKQD SVQCERKPIE VSREKSSNCA
     ASTEKIYIRK DLRSPLAATT TFVTENKTPR TTSLLDSSML VNIQQSGVKN ESILITPNKV
     EACQGDLSTL ANVVTSLANL NKTNDLPQTN TELSIIESLS NGDSSLSDLA QDDQSSSEVT
     RAFDTLAKAL NQSENSTQGS SECLGSNANL LHDVNVEIEG PLLNDVHIAF RLTMPSPMPE
     YLNVHYICES ASRLLFLSMH WARSIPSFQS LGQENSISLV KACWNELFSL GLAQCSQVMN
     VETILAAFVN HLQNSMQHDK LSSDKVKLVT DHIFKLQEFC NSMVKLCVDG YEYAYLKAIA
     LFSPDHPGLE NVSHIEKLQE KAYMEFQDYV TKTYPEDTYR LSRLLLRLPA LRLMNAAITE
     ELFFAGLIGN VQIDSIIPYI LRMETSDYNS QIIGLAV