ID   N2C1B_XENLA             Reviewed;         637 AA.
AC   Q66J63;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Nuclear receptor subfamily 2 group C member 1-B;
DE   AltName: Full=Developmental orphan receptor 2-B;
DE            Short=DOR2-B;
DE            Short=xDOR2-B;
DE   AltName: Full=Orphan nuclear receptor TR2-B;
DE   AltName: Full=Testicular receptor 2-B;
GN   Name=nr2c1-b; Synonyms=dor2 {ECO:0000250|UniProtKB:Q6GN21};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH81046.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000312|EMBL:AAH81046.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Orphan nuclear receptor. Binds the IR7 element in the
CC       promoter of its own gene in an autoregulatory negative feedback
CC       mechanism. Primarily repressor of a broad range of genes. Binds to
CC       hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half
CC       site direct repeat consensus sequences (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC       subfamily. {ECO:0000255}.
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DR   EMBL; BC081046; AAH81046.1; -; mRNA.
DR   RefSeq; NP_001087654.1; NM_001094185.1.
DR   AlphaFoldDB; Q66J63; -.
DR   DNASU; 447478; -.
DR   GeneID; 447478; -.
DR   KEGG; xla:447478; -.
DR   CTD; 447478; -.
DR   Xenbase; XB-GENE-865413; nr2c1.L.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 447478; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..637
FT                   /note="Nuclear receptor subfamily 2 group C member 1-B"
FT                   /id="PRO_0000287913"
FT   DOMAIN          383..624
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        149..224
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         152..172
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         188..207
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   637 AA;  70812 MW;  2AAD654AC4389549 CRC64;
     MASIEEIAHQ IIEQQMGEIS RSHTEVSQTA LMDGTTQRIQ LVPSESSVSV PQRIQIVTDP
     QTGQKIQIVT ALDQSGTNKQ FIFTNNDGSL PSKVILARQD SSQGKVFLTT PDAAGVNQLF
     FSTPDVPAQH IQILSDTQSL DQNLNKQFVE LCVVCGDKAS GRHYGAVTCE GCKGFFKRSI
     RKNLIYTCRG SKDCVINKHY RNRCQYCRLQ RCISLGMKQD SVQCERKPIE VSREKSSNCA
     ASTEKIYIRK DLRSPLAATT TFVTESKTSR TTSLLDSSML VNIQQSGVKN ESILLTPNKV
     EACQGDLSTL ANVVTSLANL NKSKDLPQTN TEFSIIESLS NGDSSLSDLA QDDQSNSEVT
     RAFDTLAKAL NQSENSTQGS SECVGSGSNL LPDVNVEIEG PLLNDVHIAF RLTMPSPMPE
     YLNVHYICES ASRLLFLSMH WARSIPSFLS LGQENSISLV KACWNELFSL GLAQCCQVMN
     VETILAAFVN HLHNSMQHDK LSSDKVKLVM DHIFKLQEFC NSMVKRCVDG YEYAYLKAIA
     LFSPDHPGLE NVSHIEKLQE KAYMEFQDYV TKTYPEDTYR LSRLLLRLPA LRLLNAAITE
     ELFFAGLIGN VQIDSIIPYI LRMETSDYNS QIIGLTA