N2F1B_DANRE
ID N2F1B_DANRE Reviewed; 389 AA.
AC Q6PH18; Q6P0E6;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Nuclear receptor subfamily 2 group F member 1-B {ECO:0000312|EMBL:AAH56748.1};
DE AltName: Full=COUP transcription factor 1-B {ECO:0000303|PubMed:17997606};
DE Short=COUP-TFalpha-B {ECO:0000303|PubMed:17997606};
GN Name=nr2f1b {ECO:0000312|ZFIN:ZDB-GENE-040426-1438};
GN Synonyms=nr2f1l {ECO:0000312|ZFIN:ZDB-GENE-040426-1438};
GN ORFNames=zgc:77353;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAH65651.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH65651.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=17997606; DOI=10.1371/journal.pgen.0030188;
RA Bertrand S., Thisse B., Tavares R., Sachs L., Chaumot A., Bardet P.-L.,
RA Escriva H., Duffraisse M., Marchand O., Safi R., Thisse C., Laudet V.;
RT "Unexpected novel relational links uncovered by extensive developmental
RT profiling of nuclear receptor expression.";
RL PLoS Genet. 3:E188-E188(2007).
CC -!- FUNCTION: Putative transcription factor that is required in
CC photoreceptor cells precursors during eye development. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PH18-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PH18-2; Sequence=VSP_053051;
CC -!- TISSUE SPECIFICITY: Expressed the retina, where expression is
CC restricted to the outer nuclear layer. {ECO:0000269|PubMed:17997606}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR2
CC subfamily. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC056748; AAH56748.1; -; mRNA.
DR EMBL; BC065651; AAH65651.1; -; mRNA.
DR RefSeq; NP_956886.1; NM_200592.1. [Q6PH18-1]
DR AlphaFoldDB; Q6PH18; -.
DR SMR; Q6PH18; -.
DR STRING; 7955.ENSDARP00000010118; -.
DR PaxDb; Q6PH18; -.
DR Ensembl; ENSDART00000027242; ENSDARP00000010118; ENSDARG00000017168. [Q6PH18-1]
DR GeneID; 393564; -.
DR KEGG; dre:393564; -.
DR CTD; 393564; -.
DR ZFIN; ZDB-GENE-040426-1438; nr2f1b.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000157876; -.
DR HOGENOM; CLU_007368_20_1_1; -.
DR InParanoid; Q6PH18; -.
DR OMA; NQQHVEC; -.
DR OrthoDB; 666130at2759; -.
DR PhylomeDB; Q6PH18; -.
DR TreeFam; TF352097; -.
DR PRO; PR:Q6PH18; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 10.
DR Bgee; ENSDARG00000017168; Expressed in ventricular system of central nervous system and 66 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0035476; P:angioblast cell migration; IMP:CACAO.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:1904888; P:cranial skeletal system development; IGI:ZFIN.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0001944; P:vasculature development; IMP:ZFIN.
DR GO; GO:0060841; P:venous blood vessel development; IMP:ZFIN.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..389
FT /note="Nuclear receptor subfamily 2 group F member 1-B"
FT /id="PRO_0000367031"
FT DOMAIN 152..378
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 51..126
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 54..74
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 90..109
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 19..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 123
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_053051"
SQ SEQUENCE 389 AA; 43835 MW; FE99D85A725B6F7C CRC64;
MAMVVSAWRD PQEELAAVDD QSAAGREHLQ HRHSPKSAEE KAQIAAQNQQ HVECVVCGDK
SSGKHYGQFT CEGCKSFFKR SVRRNLSYTC RANRNCPVDQ HHRNQCQYCR LKKCLKVGMR
REAVQRGRMP PNQPNPSHYA LTNGDHLNGQ CYLSGYISLL LRAEPYPASR YGNQCMQSGN
IMGIENICEL AARLLFSAVE WARNIPFFPD LQITDQVSLL RLTWSELFVL NAAQSSMPLH
VAPLLAAAGL HASPMSADRV VAFMDHIRFF QEQVEKLKAL QVDSAEYSCA KAIVLFTSDA
CGLSDIPHIE GLQEKSQCAL EEYVRSQYPN QPTRFGKLLL RLPALRMVSS SVIEQLFFVR
LVGKTPIETL IRDMLLSGSS FNWPYMPIQ
