N42L1_HUMAN
ID N42L1_HUMAN Reviewed; 243 AA.
AC Q5TBK1; A4QN21; Q5TBK0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=NEDD4-binding protein 2-like 1;
GN Name=N4BP2L1; Synonyms=CG081;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-243 (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5TBK1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5TBK1-2; Sequence=VSP_031319;
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DR EMBL; AL137247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471075; EAX08502.1; -; Genomic_DNA.
DR EMBL; CH471075; EAX08503.1; -; Genomic_DNA.
DR EMBL; BC125050; AAI25051.1; -; mRNA.
DR CCDS; CCDS41877.1; -. [Q5TBK1-2]
DR CCDS; CCDS9345.2; -. [Q5TBK1-1]
DR RefSeq; NP_001073159.1; NM_001079691.1. [Q5TBK1-2]
DR RefSeq; NP_001273388.1; NM_001286459.1. [Q5TBK1-1]
DR RefSeq; NP_438169.2; NM_052818.2. [Q5TBK1-1]
DR AlphaFoldDB; Q5TBK1; -.
DR SMR; Q5TBK1; -.
DR BioGRID; 124746; 7.
DR STRING; 9606.ENSP00000369473; -.
DR iPTMnet; Q5TBK1; -.
DR PhosphoSitePlus; Q5TBK1; -.
DR BioMuta; N4BP2L1; -.
DR DMDM; 74745960; -.
DR EPD; Q5TBK1; -.
DR MassIVE; Q5TBK1; -.
DR PaxDb; Q5TBK1; -.
DR PeptideAtlas; Q5TBK1; -.
DR PRIDE; Q5TBK1; -.
DR ProteomicsDB; 64917; -. [Q5TBK1-1]
DR ProteomicsDB; 64918; -. [Q5TBK1-2]
DR Antibodypedia; 49139; 40 antibodies from 14 providers.
DR DNASU; 90634; -.
DR Ensembl; ENST00000380130.7; ENSP00000369473.2; ENSG00000139597.18. [Q5TBK1-1]
DR Ensembl; ENST00000380133.6; ENSP00000369476.2; ENSG00000139597.18. [Q5TBK1-1]
DR Ensembl; ENST00000380139.8; ENSP00000369484.3; ENSG00000139597.18. [Q5TBK1-2]
DR Ensembl; ENST00000613078.4; ENSP00000483310.1; ENSG00000139597.18. [Q5TBK1-2]
DR GeneID; 90634; -.
DR KEGG; hsa:90634; -.
DR MANE-Select; ENST00000380130.7; ENSP00000369473.2; NM_052818.3; NP_438169.2.
DR UCSC; uc001uuc.4; human. [Q5TBK1-1]
DR CTD; 90634; -.
DR DisGeNET; 90634; -.
DR GeneCards; N4BP2L1; -.
DR HGNC; HGNC:25037; N4BP2L1.
DR HPA; ENSG00000139597; Low tissue specificity.
DR neXtProt; NX_Q5TBK1; -.
DR OpenTargets; ENSG00000139597; -.
DR PharmGKB; PA162396617; -.
DR VEuPathDB; HostDB:ENSG00000139597; -.
DR eggNOG; KOG2401; Eukaryota.
DR GeneTree; ENSGT00940000161564; -.
DR HOGENOM; CLU_083043_1_1_1; -.
DR InParanoid; Q5TBK1; -.
DR OMA; GYWNTYS; -.
DR OrthoDB; 76267at2759; -.
DR PhylomeDB; Q5TBK1; -.
DR PathwayCommons; Q5TBK1; -.
DR BioGRID-ORCS; 90634; 7 hits in 1069 CRISPR screens.
DR ChiTaRS; N4BP2L1; human.
DR GenomeRNAi; 90634; -.
DR Pharos; Q5TBK1; Tdark.
DR PRO; PR:Q5TBK1; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q5TBK1; protein.
DR Bgee; ENSG00000139597; Expressed in right lobe of liver and 200 other tissues.
DR ExpressionAtlas; Q5TBK1; baseline and differential.
DR Genevisible; Q5TBK1; HS.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR026302; NEDD4_b_p2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13308; PTHR13308; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..243
FT /note="NEDD4-binding protein 2-like 1"
FT /id="PRO_0000318958"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 133..243
FT /note="ALENNYEVIFREPDTRWKFNVQELARRNIHGVSREKIHRMKERYEHDVTFHS
FT VLHAEKPSRMNRNQDRNNALPSNNARYWNSYTEFPNRRAHGGFTNESSYHRRGGCHHGY
FT -> VFQTEQKNLFRLEMDMVVFRPEMKKHSWCLKRKNPPNERTV (in isoform
FT 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_031319"
SQ SEQUENCE 243 AA; 28981 MW; C1C662AD6B78275B CRC64;
MEDSFLQSFG RLSLQPQQQQ QRQRPPRPPP RGTPPRRHSF RKHLYLLRGL PGSGKTTLAR
QLQHDFPRAL IFSTDDFFFR EDGAYEFNPD FLEEAHEWNQ KRARKAMRNG ISPIIIDNTN
LHAWEMKPYA VMALENNYEV IFREPDTRWK FNVQELARRN IHGVSREKIH RMKERYEHDV
TFHSVLHAEK PSRMNRNQDR NNALPSNNAR YWNSYTEFPN RRAHGGFTNE SSYHRRGGCH
HGY
