N42L1_MOUSE
ID N42L1_MOUSE Reviewed; 238 AA.
AC Q3V2Q8; Q3UU88; Q8BL78; Q8VE50;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=NEDD4-binding protein 2-like 1;
GN Name=N4bp2l1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Corpora quadrigemina, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3V2Q8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3V2Q8-2; Sequence=VSP_031320;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC32606.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK046116; BAC32606.1; ALT_FRAME; mRNA.
DR EMBL; AK131647; BAE20739.1; -; mRNA.
DR EMBL; AK138666; BAE23739.1; -; mRNA.
DR EMBL; BC019754; AAH19754.1; -; mRNA.
DR CCDS; CCDS19887.1; -. [Q3V2Q8-1]
DR RefSeq; NP_598659.3; NM_133898.4. [Q3V2Q8-1]
DR AlphaFoldDB; Q3V2Q8; -.
DR SMR; Q3V2Q8; -.
DR STRING; 10090.ENSMUSP00000016279; -.
DR iPTMnet; Q3V2Q8; -.
DR PhosphoSitePlus; Q3V2Q8; -.
DR EPD; Q3V2Q8; -.
DR MaxQB; Q3V2Q8; -.
DR PaxDb; Q3V2Q8; -.
DR PeptideAtlas; Q3V2Q8; -.
DR PRIDE; Q3V2Q8; -.
DR ProteomicsDB; 286133; -. [Q3V2Q8-1]
DR ProteomicsDB; 286134; -. [Q3V2Q8-2]
DR Antibodypedia; 49139; 40 antibodies from 14 providers.
DR DNASU; 100637; -.
DR Ensembl; ENSMUST00000016279; ENSMUSP00000016279; ENSMUSG00000041132. [Q3V2Q8-1]
DR Ensembl; ENSMUST00000202031; ENSMUSP00000144164; ENSMUSG00000041132. [Q3V2Q8-2]
DR GeneID; 100637; -.
DR KEGG; mmu:100637; -.
DR UCSC; uc009aub.2; mouse. [Q3V2Q8-1]
DR CTD; 90634; -.
DR MGI; MGI:2140872; N4bp2l1.
DR VEuPathDB; HostDB:ENSMUSG00000041132; -.
DR eggNOG; KOG2401; Eukaryota.
DR GeneTree; ENSGT00940000161564; -.
DR HOGENOM; CLU_083043_1_0_1; -.
DR InParanoid; Q3V2Q8; -.
DR OMA; GYWNTYS; -.
DR OrthoDB; 76267at2759; -.
DR PhylomeDB; Q3V2Q8; -.
DR TreeFam; TF339118; -.
DR BioGRID-ORCS; 100637; 3 hits in 72 CRISPR screens.
DR ChiTaRS; N4bp2l1; mouse.
DR PRO; PR:Q3V2Q8; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q3V2Q8; protein.
DR Bgee; ENSMUSG00000041132; Expressed in dorsomedial nucleus of hypothalamus and 225 other tissues.
DR ExpressionAtlas; Q3V2Q8; baseline and differential.
DR Genevisible; Q3V2Q8; MM.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR026302; NEDD4_b_p2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13308; PTHR13308; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..238
FT /note="NEDD4-binding protein 2-like 1"
FT /id="PRO_0000318959"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..104
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031320"
FT CONFLICT 130
FT /note="M -> V (in Ref. 1; BAC32606)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 238 AA; 28038 MW; 8E55135F6EC4E9F9 CRC64;
MEDSFLESFG RLSLQQRQQQ PPPRPPPARG PPPRRHSFRK HLYLLRGLPG SGKTTLARQL
QHDYPRALIF STDDFFFKED GTYEFNPNLL EEAHEWNQRR ARKAMRNGIS PIIIDNTNLH
AWEMKPYAVM ALENNYEVIF REPDTRWKFN VQELARRNIH GVPKEKIQRM KERYEHNVTF
HSVLHAEKPS RANRNQGRNS EPSSGSGYWN TYTELPNRRA NGLYSNEGYR RGGHHQGY
