N42L2_MOUSE
ID N42L2_MOUSE Reviewed; 575 AA.
AC Q8JZS6;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=NEDD4-binding protein 2-like 2;
DE AltName: Full=Phosphonoformate immuno-associated protein 5 homolog;
GN Name=N4bp2l2; Synonyms=Pfaap5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8JZS6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8JZS6-2; Sequence=VSP_027519, VSP_027520;
CC -!- MISCELLANEOUS: [Isoform 2]: Due to a partial intron retention.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC158558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC037393; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS19888.2; -. [Q8JZS6-1]
DR RefSeq; NP_958757.2; NM_201369.3. [Q8JZS6-1]
DR AlphaFoldDB; Q8JZS6; -.
DR SMR; Q8JZS6; -.
DR BioGRID; 238052; 3.
DR STRING; 10090.ENSMUSP00000113895; -.
DR iPTMnet; Q8JZS6; -.
DR PhosphoSitePlus; Q8JZS6; -.
DR EPD; Q8JZS6; -.
DR MaxQB; Q8JZS6; -.
DR PaxDb; Q8JZS6; -.
DR PeptideAtlas; Q8JZS6; -.
DR PRIDE; Q8JZS6; -.
DR ProteomicsDB; 287552; -. [Q8JZS6-1]
DR ProteomicsDB; 287553; -. [Q8JZS6-2]
DR Antibodypedia; 42083; 236 antibodies from 22 providers.
DR DNASU; 381695; -.
DR Ensembl; ENSMUST00000118316; ENSMUSP00000113895; ENSMUSG00000029655. [Q8JZS6-1]
DR GeneID; 381695; -.
DR KEGG; mmu:381695; -.
DR UCSC; uc009aug.3; mouse. [Q8JZS6-2]
DR UCSC; uc012eho.1; mouse. [Q8JZS6-1]
DR CTD; 10443; -.
DR MGI; MGI:2687207; N4bp2l2.
DR VEuPathDB; HostDB:ENSMUSG00000029655; -.
DR eggNOG; KOG2401; Eukaryota.
DR GeneTree; ENSGT00940000161440; -.
DR HOGENOM; CLU_006655_0_0_1; -.
DR InParanoid; Q8JZS6; -.
DR OMA; DINCHGP; -.
DR OrthoDB; 76267at2759; -.
DR PhylomeDB; Q8JZS6; -.
DR TreeFam; TF339118; -.
DR BioGRID-ORCS; 381695; 0 hits in 72 CRISPR screens.
DR ChiTaRS; N4bp2l2; mouse.
DR PRO; PR:Q8JZS6; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8JZS6; protein.
DR Bgee; ENSMUSG00000029655; Expressed in spermatid and 195 other tissues.
DR ExpressionAtlas; Q8JZS6; baseline and differential.
DR Genevisible; Q8JZS6; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0017053; C:transcription repressor complex; ISO:MGI.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR GO; GO:0003714; F:transcription corepressor activity; IMP:UniProtKB.
DR GO; GO:0001824; P:blastocyst development; IMP:MGI.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR GO; GO:1902037; P:negative regulation of hematopoietic stem cell differentiation; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR GO; GO:1902035; P:positive regulation of hematopoietic stem cell proliferation; ISO:MGI.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR026568; NEDD4-bind_pro_2-like_2.
DR InterPro; IPR026302; NEDD4_b_p2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13308; PTHR13308; 1.
DR PANTHER; PTHR13308:SF23; PTHR13308:SF23; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..575
FT /note="NEDD4-binding protein 2-like 2"
FT /id="PRO_0000299027"
FT REGION 69..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 162..194
FT /evidence="ECO:0000255"
FT COMPBIAS 69..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 454..495
FT /note="AKQAIDQGRSPVIIDNTNTQAWEMKPYVEMAIGKGYRVEFHE -> GLFWAK
FT VPGMEYLITGHT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027519"
FT VAR_SEQ 496..575
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027520"
SQ SEQUENCE 575 AA; 66250 MW; C41FAA8CC3EE4408 CRC64;
MPYSEVEAKF LGPGKEQTRE PCYKKLKSAA DDGVSPLRGG PDIHRIQEKP RNNRVAVATI
NFRRRVCPQE DKTSTDVLKP LHKEMPGDKL GGSESIGSPA LQDGKPSPLA KDDEIYSTSK
AFIGPIYKPP EKKKCRERKS ETDTFSSIDS KRRQEEKQKS NSKKLEMDTE LSQFYKEIEE
LENENEASQG SCTEPEPSEE PIISYDWACN TLKSEEENKD LSDVLQSHCG YQEYLEDEPD
YPCDEQLMPA FCETSFPSFR PEWQSMHPFV IPHDPLSSFN YFNFQRFGTP LHPSPDVFHG
RDDSQMQNGC YVDSYQDGWS CLTFDQNDEY ANYDVTSNNV HPFRNGCSVQ DESVNNGFCE
IRECWQDPSM DKHNETDRFV NQWFQEEKLN KLQKLLILLR GLPGSGKTTL SRILLGQSRD
GIVFSTDDYF HHQDGYRYNV NQLGDAHDWN QNRAKQAIDQ GRSPVIIDNT NTQAWEMKPY
VEMAIGKGYR VEFHEPETWW KFDPEELEKR NKHGVSRKKI AQMLDRYEFQ MSISIVMNSV
EPTQKSIQRP LPLEGEQRWG GSLGSHSQVS IADDY
