ID   N42L2_RAT               Reviewed;         574 AA.
AC   Q66H65;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=NEDD4-binding protein 2-like 2;
DE   AltName: Full=Phosphonoformate immuno-associated protein 5 homolog;
GN   Name=N4bp2l2; Synonyms=Pfaap5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC081998; AAH81998.1; -; mRNA.
DR   RefSeq; NP_001005533.1; NM_001005533.1.
DR   RefSeq; XP_006248797.1; XM_006248735.2.
DR   AlphaFoldDB; Q66H65; -.
DR   STRING; 10116.ENSRNOP00000001468; -.
DR   PaxDb; Q66H65; -.
DR   Ensembl; ENSRNOT00000001468; ENSRNOP00000001468; ENSRNOG00000001108.
DR   GeneID; 288416; -.
DR   KEGG; rno:288416; -.
DR   UCSC; RGD:1359603; rat.
DR   CTD; 10443; -.
DR   RGD; 1359603; N4bp2l2.
DR   eggNOG; KOG2401; Eukaryota.
DR   GeneTree; ENSGT00940000161440; -.
DR   HOGENOM; CLU_006655_0_0_1; -.
DR   InParanoid; Q66H65; -.
DR   OMA; DINCHGP; -.
DR   OrthoDB; 76267at2759; -.
DR   PhylomeDB; Q66H65; -.
DR   TreeFam; TF339118; -.
DR   PRO; PR:Q66H65; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000001108; Expressed in testis and 20 other tissues.
DR   Genevisible; Q66H65; RN.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0017053; C:transcription repressor complex; ISO:RGD.
DR   GO; GO:0019899; F:enzyme binding; ISO:RGD.
DR   GO; GO:0003714; F:transcription corepressor activity; ISS:CAFA.
DR   GO; GO:0001824; P:blastocyst development; ISO:RGD.
DR   GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR   GO; GO:1902037; P:negative regulation of hematopoietic stem cell differentiation; ISO:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:CAFA.
DR   GO; GO:1902035; P:positive regulation of hematopoietic stem cell proliferation; ISO:RGD.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR026568; NEDD4-bind_pro_2-like_2.
DR   InterPro; IPR026302; NEDD4_b_p2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR13308; PTHR13308; 1.
DR   PANTHER; PTHR13308:SF23; PTHR13308:SF23; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..574
FT                   /note="NEDD4-binding protein 2-like 2"
FT                   /id="PRO_0000299028"
FT   REGION          82..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          127..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          182..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          542..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          162..196
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        190..204
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   574 AA;  65666 MW;  5433635D4614689D CRC64;
     MPYSEIEAKF LGPGKELTRE PCYKKLKSAV DDGVFPHRGG PDSHRIQEKT KNNRLPVATI
     NFRRRVCPGE DKTSTDVLKP LHKEMPGDKV GGTESIGSQA LQDGKPLAPA RDDEIYSTSK
     AFIGPIYKPP EKKKCRERKN ETATFNNTDS KRRQEEKQKF NSKKLEIDTE LSQFYKEIEE
     LENENEASQG SCKEPEPSQE QTLSHDQACN TLKPEGESKD LSTVLQSHCG YQPYLEDESD
     YPCDEQLIPA FCDTSFPSFR PEWQSVHPFV IPHDPLPSFN YFNIQRFGAP LHPPPSVFHA
     RDDARLQSGC YIDSYQDGWS CLTLDQNDEY ANYDVPGNVH PFGNGYGVQD DSVKNGFCEI
     RECWQDPSMD MHNEADRFVN QCFQEDRLNK LQKLLILLRG LPGSGKTTLS RILLGQSRDG
     IVFSTDDYFH HQDGYRYNVN QLGDAHDWNQ NRAKQAIDQG RSPVIIDNTN TQAWEMKPYV
     EMAIGKGYRV EFHEPETWWK FDPEELEKRN KHGVSRKKIA QMLDRYEFQM SISIVMNSVE
     PTQKSTQTPL PLQGDQRWGG SLGSHSQVSI TDDY