N4BP1_CHICK
ID N4BP1_CHICK Reviewed; 931 AA.
AC Q5ZLE9;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=NEDD4-binding protein 1 {ECO:0000250|UniProtKB:Q6A037};
DE Short=N4BP1 {ECO:0000250|UniProtKB:Q6A037};
DE EC=3.1.-.- {ECO:0000250|UniProtKB:O75113};
GN Name=N4BP1 {ECO:0000250|UniProtKB:Q6A037};
GN ORFNames=RCJMB04_6i4 {ECO:0000303|PubMed:15642098};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Potent suppressor of cytokine production that acts as a
CC regulator of innate immune signaling and inflammation. Acts as a key
CC negative regulator of select cytokine and chemokine responses elicited
CC by TRIF-independent Toll-like receptors (TLRs), thereby limiting
CC inflammatory cytokine responses to minor insults (By similarity). Has
CC ribonuclease activity (By similarity). {ECO:0000250|UniProtKB:O75113,
CC ECO:0000250|UniProtKB:Q6A037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q6A037}. Nucleus {ECO:0000250|UniProtKB:Q6A037}.
CC Nucleus, nucleolus {ECO:0000250|UniProtKB:Q6A037}. Nucleus, PML body
CC {ECO:0000250|UniProtKB:Q6A037}. Note=Primarily localizes to the
CC nucleolus. Also localizes to the PML nuclear bodies, when desumoylated.
CC {ECO:0000250|UniProtKB:Q6A037}.
CC -!- SIMILARITY: Belongs to the N4BP1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ719785; CAG31444.1; -; mRNA.
DR RefSeq; NP_001025741.1; NM_001030570.1.
DR AlphaFoldDB; Q5ZLE9; -.
DR SMR; Q5ZLE9; -.
DR STRING; 9031.ENSGALP00000006197; -.
DR PaxDb; Q5ZLE9; -.
DR PRIDE; Q5ZLE9; -.
DR GeneID; 415739; -.
DR KEGG; gga:415739; -.
DR CTD; 9683; -.
DR VEuPathDB; HostDB:geneid_415739; -.
DR eggNOG; KOG3777; Eukaryota.
DR InParanoid; Q5ZLE9; -.
DR OrthoDB; 771251at2759; -.
DR PhylomeDB; Q5ZLE9; -.
DR PRO; PR:Q5ZLE9; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016605; C:PML body; ISS:UniProtKB.
DR GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR GO; GO:0004540; F:ribonuclease activity; ISS:UniProtKB.
DR GO; GO:0043130; F:ubiquitin binding; ISS:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0001818; P:negative regulation of cytokine production; ISS:UniProtKB.
DR GO; GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR GO; GO:0031397; P:negative regulation of protein ubiquitination; ISS:UniProtKB.
DR GO; GO:0045071; P:negative regulation of viral genome replication; ISS:UniProtKB.
DR GO; GO:0045088; P:regulation of innate immune response; ISS:UniProtKB.
DR InterPro; IPR021869; RNase_Zc3h12_NYN.
DR Pfam; PF11977; RNase_Zc3h12a; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Hydrolase; Immunity; Innate immunity; Nuclease; Nucleus;
KW Reference proteome; RNA-binding.
FT CHAIN 1..931
FT /note="NEDD4-binding protein 1"
FT /id="PRO_0000301986"
FT DOMAIN 75..159
FT /note="KH-like"
FT /evidence="ECO:0000255"
FT DOMAIN 659..811
FT /note="RNase NYN"
FT /evidence="ECO:0000255"
FT REGION 289..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..931
FT /note="CoCUN"
FT /evidence="ECO:0000250|UniProtKB:O75113"
FT COMPBIAS 292..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 931 AA; 104047 MW; 908DD631EC6E6911 CRC64;
MAARWAAHGP GPGLDEFTVP AEKRRFLEGS RGRIQGLFEV RLAVLEAQGD WRPALPPPGQ
PPPAARIWVQ LAGGGKAVRS AKEYIKGLCE PELEEKEYYP KDMHCIFVGA QNMFLNSLIQ
DTCADITVLE IGLLSIKGGA EAVVMAQSQV QQFVKLFENN ESLSSECESD IKKQFRQFVE
AHADKYTMDL LILPSSLKRE LLTLMQTECC ESRGAIIDLT GSKSPAELLQ DKTSKVILTS
RDGKMGDEEE RNNAGTPVTE LTKQMDNVFS DAPETSFVPI NVVPPLEAMT SKERQSCKRR
FSDAEESLPK KQLSLENDQE VKSVSHNDSS KRDAVIDLIS DSSGELDDPS YCIKEGDDIS
EEIEYKILVN FFRTMGYSQS IVEKVIGVLG QSVEPLTLLE EIEKENLRFQ KEQEWSSKTP
KTTNLRLGSN ANSSHKLEDE DISCKKNPLK TTHTSNETRT ERHKARDMPS TQVDAEDKMH
VSVCKPVSPD KSSAICYKKT DIYCPGKNHN STSSDAETDG FVPLSPPQAG APKDVDFVAR
GSSDVRCTSA KSKTAVHQKS AGPSPVQNSH SVVEDQLGHC SSYQVRSPNQ HTSQMSNFEN
PTQAHVLSSE IHSANPDREV SGSHRRHIDP SITGVQRFLE SLKKPYRLEL KNEPGKPYLK
HIIIDGSNVA ISHGLRKFFS CRGIAIAVDY FWKRGHRNIT VFVPQWRTRR DPSITEQDFL
TQLEDVGILS LTPSRMVLGA RIASHDDRFL LHLADKTGGV IVTNDNFREF VTESLAWREI
IQKRLLQYTF AGDIFMVPDD PLGRNGPRLD DFLQSEGCSR DFLSAQKALQ SREQYSSETP
LFMHVPNPAS SSQQPKNRAH GDHSAAWLPL DTNMKACLSI PPQRSASETV WLREALIKIF
PDYEQRQKID KILADHPFMR DLNALSAMVL D
