N4BP3_CHICK
ID N4BP3_CHICK Reviewed; 431 AA.
AC Q5ZLT3;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=NEDD4-binding protein 3 homolog;
DE Short=N4BP3 homolog;
GN Name=N4BP3 {ECO:0000250|UniProtKB:O15049}; ORFNames=RCJMB04_4o21;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1] {ECO:0000312|EMBL:CAG31310.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB {ECO:0000312|EMBL:CAG31310.1}; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Plays a role in axon and dendrite arborization during cranial
CC nerve development. May also be important for neural crest migration and
CC early development of other anterior structures including eye, brain and
CC cranial cartilage. {ECO:0000250|UniProtKB:A0A1L8GXY6}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle
CC {ECO:0000250|UniProtKB:O15049}. Cell projection, axon
CC {ECO:0000250|UniProtKB:Q3LUD3}. Cell projection, dendrite
CC {ECO:0000250|UniProtKB:Q3LUD3}. Note=In developing neurons, accumulates
CC in early growth cones and at branching points of axons and dendrites.
CC {ECO:0000250|UniProtKB:Q3LUD3}.
CC -!- SIMILARITY: Belongs to the N4BP3 family. {ECO:0000305}.
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DR EMBL; AJ719651; CAG31310.1; -; mRNA.
DR RefSeq; NP_001026778.1; NM_001031607.1.
DR AlphaFoldDB; Q5ZLT3; -.
DR SMR; Q5ZLT3; -.
DR STRING; 9031.ENSGALP00000022701; -.
DR PaxDb; Q5ZLT3; -.
DR PRIDE; Q5ZLT3; -.
DR GeneID; 431542; -.
DR KEGG; gga:431542; -.
DR CTD; 23138; -.
DR VEuPathDB; HostDB:geneid_431542; -.
DR eggNOG; ENOG502QVNK; Eukaryota.
DR InParanoid; Q5ZLT3; -.
DR OrthoDB; 697945at2759; -.
DR PhylomeDB; Q5ZLT3; -.
DR PRO; PR:Q5ZLT3; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR InterPro; IPR033571; N4BP3.
DR PANTHER; PTHR32274; PTHR32274; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Coiled coil; Cytoplasmic vesicle; Developmental protein;
KW Neurogenesis; Reference proteome.
FT CHAIN 1..431
FT /note="NEDD4-binding protein 3 homolog"
FT /id="PRO_0000397911"
FT REGION 48..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 284..390
FT /evidence="ECO:0000255"
FT COMPBIAS 75..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 431 AA; 47789 MW; 8C817D1C06FC2234 CRC64;
MAAAQGPVSC EPDTRVLGTY LSSVPIGSMG SVGSLVEKQD LSPLELRAPL GGTRGLRQPD
GLLRKGPSQR ELFGYLHGAK KETRSERKHQ ASAACYKRDY ESDRENRSPE RCSREHHRGA
DFSKSSLPER GRFDKCRIRP SAFKAVTGKG LVSMQGLSSS KGQKLSKSNG SLHTLLSQST
TAAPQHGPLR THLLHAISLD EASDSSHNSI QSFPSYGSRL KPAQSQFSAS MGHINHIGGS
LDRVSRSPRD PLAPEKAPLS CKSMATLSRL QSPGEPPPPY EFTYSLEDAV KQLEDRLKET
GGELRQLKRS LSETEDPFAQ AFEDKQRLWL DELEDLKQMY MARLQQVTQQ AQRGQRALQL
QLYKAQQEKK RLQEELSMQQ CQCEETKLRQ SQGERVSPKL EETKWEVSPL LSLSVATLQA
VQPGWGSGSL L
