N4BP3_MOUSE
ID N4BP3_MOUSE Reviewed; 537 AA.
AC Q8C7U1; A2AA64; Q3TDC7; Q3URT6; Q7TNR2; Q922W0; Q99J06;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=NEDD4-binding protein 3;
DE Short=N4BP3;
GN Name=N4bp3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Dendritic cell, Embryonic stem cell, and Embryonic stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plays a positive role in the antiviral innate immune
CC signaling pathway. Mechanistically, interacts with MAVS and functions
CC as a positive regulator to promote 'Lys-63'-linked polyubiquitination
CC of MAVS and thus strengthens the interaction between MAVS and TRAF2 (By
CC similarity). Also plays a role in axon and dendrite arborization during
CC cranial nerve development. May also be important for neural crest
CC migration and early development of other anterior structures including
CC eye, brain and cranial cartilage (By similarity).
CC {ECO:0000250|UniProtKB:A0A1L8GXY6, ECO:0000250|UniProtKB:O15049}.
CC -!- SUBUNIT: Binds NEDD4. Interacts with 14-3-3 proteins. Interacts with
CC MAVS. {ECO:0000250|UniProtKB:O15049}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle
CC {ECO:0000250|UniProtKB:Q3LUD3}. Cell projection, axon
CC {ECO:0000250|UniProtKB:Q3LUD3}. Cell projection, dendrite
CC {ECO:0000250|UniProtKB:Q3LUD3}. Note=In developing neurons, accumulates
CC in early growth cones and at branching points of axons and dendrites.
CC {ECO:0000250|UniProtKB:Q3LUD3}.
CC -!- SIMILARITY: Belongs to the N4BP3 family. {ECO:0000305}.
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DR EMBL; AK049249; BAC33636.1; -; mRNA.
DR EMBL; AK141228; BAE24601.1; -; mRNA.
DR EMBL; AK142500; BAE25088.1; -; mRNA.
DR EMBL; AK170270; BAE41675.1; -; mRNA.
DR EMBL; AK170521; BAE41855.1; -; mRNA.
DR EMBL; AL645602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466575; EDL33646.1; -; Genomic_DNA.
DR EMBL; CH466575; EDL33647.1; -; Genomic_DNA.
DR EMBL; CH466575; EDL33648.1; -; Genomic_DNA.
DR EMBL; BC005767; AAH05767.1; -; mRNA.
DR EMBL; BC006740; AAH06740.2; -; mRNA.
DR EMBL; BC055831; AAH55831.2; -; mRNA.
DR CCDS; CCDS24657.1; -.
DR RefSeq; NP_666086.2; NM_145974.3.
DR RefSeq; XP_006532827.1; XM_006532764.3.
DR RefSeq; XP_006532828.1; XM_006532765.3.
DR RefSeq; XP_006532829.1; XM_006532766.3.
DR AlphaFoldDB; Q8C7U1; -.
DR SMR; Q8C7U1; -.
DR BioGRID; 229350; 1.
DR IntAct; Q8C7U1; 1.
DR STRING; 10090.ENSMUSP00000001080; -.
DR iPTMnet; Q8C7U1; -.
DR PhosphoSitePlus; Q8C7U1; -.
DR MaxQB; Q8C7U1; -.
DR PaxDb; Q8C7U1; -.
DR PeptideAtlas; Q8C7U1; -.
DR PRIDE; Q8C7U1; -.
DR ProteomicsDB; 252635; -.
DR Antibodypedia; 29410; 87 antibodies from 20 providers.
DR Ensembl; ENSMUST00000001080; ENSMUSP00000001080; ENSMUSG00000001053.
DR GeneID; 212706; -.
DR KEGG; mmu:212706; -.
DR UCSC; uc007iue.1; mouse.
DR CTD; 23138; -.
DR MGI; MGI:2442218; N4bp3.
DR VEuPathDB; HostDB:ENSMUSG00000001053; -.
DR eggNOG; ENOG502QVNK; Eukaryota.
DR GeneTree; ENSGT00940000158603; -.
DR HOGENOM; CLU_026379_3_1_1; -.
DR InParanoid; Q8C7U1; -.
DR OMA; EFSCPTT; -.
DR OrthoDB; 697945at2759; -.
DR PhylomeDB; Q8C7U1; -.
DR TreeFam; TF331420; -.
DR BioGRID-ORCS; 212706; 2 hits in 72 CRISPR screens.
DR ChiTaRS; N4bp3; mouse.
DR PRO; PR:Q8C7U1; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8C7U1; protein.
DR Bgee; ENSMUSG00000001053; Expressed in interventricular septum and 185 other tissues.
DR ExpressionAtlas; Q8C7U1; baseline and differential.
DR Genevisible; Q8C7U1; MM.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR InterPro; IPR033571; N4BP3.
DR PANTHER; PTHR32274; PTHR32274; 1.
PE 1: Evidence at protein level;
KW Cell projection; Coiled coil; Cytoplasmic vesicle; Developmental protein;
KW Neurogenesis; Phosphoprotein; Reference proteome.
FT CHAIN 1..537
FT /note="NEDD4-binding protein 3"
FT /id="PRO_0000096683"
FT REGION 173..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 295..501
FT /evidence="ECO:0000255"
FT COMPBIAS 179..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 172
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 203
FT /note="S -> I (in Ref. 4; AAH06740)"
FT /evidence="ECO:0000305"
FT CONFLICT 233
FT /note="S -> G (in Ref. 1; BAE24601)"
FT /evidence="ECO:0000305"
FT CONFLICT 344..345
FT /note="GS -> HA (in Ref. 4; AAH05767)"
FT /evidence="ECO:0000305"
FT CONFLICT 347
FT /note="M -> V (in Ref. 4; AAH05767)"
FT /evidence="ECO:0000305"
FT CONFLICT 493
FT /note="V -> A (in Ref. 1; BAE24601)"
FT /evidence="ECO:0000305"
FT CONFLICT 505
FT /note="M -> R (in Ref. 1; BAE24601)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 537 AA; 60042 MW; 35800845E3DBE379 CRC64;
MATTSGPAGI AMGSVGSLLE RQDFSPEELR AALAGSRGSR QPDGLLRKGL GQREFFSYLH
LPKKDGKTTK RAPRNEPDYA TLYYREHPRA GDFSKTSLPE RGRFDKCRIR PSVFKPPVGS
GKGFLSMQSL AAHKGQKLWR SNGSLHTLAC HPPLSPGPRA SQARAQLLHA LSLDEGGPEP
SLSDSSSGGS FGRSPGTGPS PFSSSLGHIN HLGGSLDRAP RSPKESGPLA VLSCLPEPPP
PYEFSCPTTE EVAVLPEARE ELKRDLGDQD VSNSFTQVLE ERQRLWLSEL KRLYVERLHE
VAQKAERSER NLQLQLFMAQ QEQRRLRKEL RAQQGLAPEP RTSGSSMEAD PNARPEEEAR
WEVCQKTAEI SLLKQQLREA QAELAQKLAE IFSLKTQLRG SRAQAQAQDA ELARLREAVH
SLQEQAPREE APGSCETDDC KSRGLLGEAG GSEAREGAEQ LRAELLQERL RGQEQALRFE
QERQTWQEEK ERVLRYQREI QGSYMDMYRR NQALEHELRL LREPPTSWSP RLESSKI
