ID   N4BP3_RAT               Reviewed;         537 AA.
AC   Q3LUD3;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Nedd4 binding protein 3 {ECO:0000312|EMBL:ABA06436.1};
DE            Short=N4BP3 {ECO:0000250|UniProtKB:O15049};
GN   Name=N4bp3 {ECO:0000312|RGD:1308356};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:ABA06436.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain {ECO:0000312|EMBL:ABA06436.1};
RX   PubMed=16522626; DOI=10.1074/jbc.m601101200;
RA   Wendholt D., Spilker C., Schmitt A., Dolnik A., Smalla K.H., Proepper C.,
RA   Bockmann J., Sobue K., Gundelfinger E.D., Kreutz M.R., Boeckers T.M.;
RT   "ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the
RT   postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the
RT   scaffolding protein ProSAP2/Shank3.";
RL   J. Biol. Chem. 281:13805-13816(2006).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=24044555; DOI=10.1186/1749-8104-8-18;
RA   Schmeisser M.J., Kuehl S.J., Schoen M., Beth N.H., Weis T.M.,
RA   Grabrucker A.M., Kuehl M., Boeckers T.M.;
RT   "The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic
RT   branching in developing neurons.";
RL   Neural Dev. 8:18-18(2013).
CC   -!- FUNCTION: Plays a positive role in the antiviral innate immune
CC       signaling pathway. Mechanistically, interacts with MAVS and functions
CC       as a positive regulator to promote 'Lys-63'-linked polyubiquitination
CC       of MAVS and thus strengthens the interaction between MAVS and TRAF2 (By
CC       similarity). Also plays a role in axon and dendrite arborization during
CC       cranial nerve development (PubMed:24044555). May also be important for
CC       neural crest migration and early development of other anterior
CC       structures including eye, brain and cranial cartilage
CC       (PubMed:24044555). {ECO:0000250|UniProtKB:O15049,
CC       ECO:0000269|PubMed:24044555}.
CC   -!- SUBUNIT: Binds NEDD4. Interacts with 14-3-3 proteins. Interacts with
CC       MAVS. {ECO:0000250|UniProtKB:O15049}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle
CC       {ECO:0000269|PubMed:24044555}. Cell projection, axon
CC       {ECO:0000269|PubMed:24044555}. Cell projection, dendrite
CC       {ECO:0000269|PubMed:24044555}. Note=In developing neurons, accumulates
CC       in early growth cones and at branching points of axons and dendrites.
CC       {ECO:0000269|PubMed:24044555}.
CC   -!- SIMILARITY: Belongs to the N4BP3 family. {ECO:0000305}.
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DR   EMBL; DQ176639; ABA06436.1; -; mRNA.
DR   RefSeq; NP_001029065.1; NM_001033893.1.
DR   RefSeq; XP_006246315.1; XM_006246253.3.
DR   RefSeq; XP_008765903.1; XM_008767681.2.
DR   RefSeq; XP_017459544.1; XM_017604055.1.
DR   AlphaFoldDB; Q3LUD3; -.
DR   SMR; Q3LUD3; -.
DR   STRING; 10116.ENSRNOP00000030035; -.
DR   PaxDb; Q3LUD3; -.
DR   PRIDE; Q3LUD3; -.
DR   Ensembl; ENSRNOT00000032386; ENSRNOP00000030035; ENSRNOG00000021731.
DR   GeneID; 303112; -.
DR   KEGG; rno:303112; -.
DR   UCSC; RGD:1308356; rat.
DR   CTD; 23138; -.
DR   RGD; 1308356; N4bp3.
DR   eggNOG; ENOG502QVNK; Eukaryota.
DR   GeneTree; ENSGT00940000158603; -.
DR   HOGENOM; CLU_026379_3_1_1; -.
DR   InParanoid; Q3LUD3; -.
DR   OMA; EFSCPTT; -.
DR   OrthoDB; 697945at2759; -.
DR   PhylomeDB; Q3LUD3; -.
DR   TreeFam; TF331420; -.
DR   PRO; PR:Q3LUD3; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000021731; Expressed in ovary and 19 other tissues.
DR   Genevisible; Q3LUD3; RN.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISO:RGD.
DR   GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   InterPro; IPR033571; N4BP3.
DR   PANTHER; PTHR32274; PTHR32274; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Coiled coil; Cytoplasmic vesicle; Developmental protein;
KW   Neurogenesis; Phosphoprotein; Reference proteome.
FT   CHAIN           1..537
FT                   /note="Nedd4 binding protein 3"
FT                   /id="PRO_0000397910"
FT   REGION          173..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          327..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          422..456
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          295..523
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        179..210
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         172
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O15049"
SQ   SEQUENCE   537 AA;  60048 MW;  5CB17A3C87182AE3 CRC64;
     MATASGPAGI AMGSVGSLLE RQDFSPEELR AALAGSRGSR QPDGLLRKGL GQREFFSYLH
     LPKKDGKTAK RAPRNEPDYT TLYYREHPRA GDFSKTSLPE RGRFDKCRIR PSVFKPPVST
     GKGFLSMQSL AAHKGQKLWR SNGSLHTLAC HPPLSPGPRA SQARAQLLHA LSLDEGGPEP
     SLSDSSSGGS FGRSPGTGPS PFSSSLGHIN HLGGSLDRAS RSPKESGPLA VLSCLPEPPP
     PYEFSCPTTE EVAVLPDTCE ELKRDLGDQD VSNPFTQVLE ERQRLWLSEL KRLYVDRLHE
     VAQKAERSER NLQLQLFMAQ QEQRRLRKEL RAQQGLAPEP RTSGPPMEAD PNARPEEEAR
     WEVCQKTAEI SLLKQQLREA QAELAQKLAE IFSLKTQLRG SRAQAQAQDA ELARLREAVR
     SLQEQAPREE APGSCETDDC KSRGLLGEAG GNEAREGAEQ LRAELLQERL RGQEQALRFE
     QERQTWQEEK ERVLRYQREI QGSYMDMYRR NQALEQELRV LREPPTSWSP RLESSKI