ID   N7BML_YARLI             Reviewed;         237 AA.
AC   Q6C7L6;
DT   24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=NADH-ubiquinone oxidoreductase assembly factor N7BML {ECO:0000303|PubMed:25902503};
DE   AltName: Full=N7BM-like protein {ECO:0000303|PubMed:25902503};
DE   AltName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 homolog;
DE            Short=NDUFAF2 homolog {ECO:0000303|PubMed:25902503};
GN   Name=N7BML {ECO:0000303|PubMed:25902503}; OrderedLocusNames=YALI0D27082g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=25902503; DOI=10.1073/pnas.1424353112;
RA   Kmita K., Wirth C., Warnau J., Guerrero-Castillo S., Hunte C., Hummer G.,
RA   Kaila V.R., Zwicker K., Brandt U., Zickermann V.;
RT   "Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential
RT   for biogenesis of mitochondrial complex I.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:5685-5690(2015).
CC   -!- FUNCTION: Acts as an assembly factor of mitochondrial complex I.
CC       {ECO:0000269|PubMed:25902503}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25902503}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFA12 subunit family.
CC       {ECO:0000305}.
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DR   EMBL; CR382130; CAG81552.1; -; Genomic_DNA.
DR   RefSeq; XP_503346.1; XM_503346.1.
DR   PDB; 6RFQ; EM; 3.30 A; k=1-237.
DR   PDBsum; 6RFQ; -.
DR   AlphaFoldDB; Q6C7L6; -.
DR   SMR; Q6C7L6; -.
DR   STRING; 4952.CAG81552; -.
DR   PRIDE; Q6C7L6; -.
DR   EnsemblFungi; CAG81552; CAG81552; YALI0_D27082g.
DR   GeneID; 2911242; -.
DR   KEGG; yli:YALI0D27082g; -.
DR   VEuPathDB; FungiDB:YALI0_D27082g; -.
DR   HOGENOM; CLU_067876_0_0_1; -.
DR   InParanoid; Q6C7L6; -.
DR   OMA; PEETMEH; -.
DR   Proteomes; UP000001300; Chromosome D.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:InterPro.
DR   InterPro; IPR007763; NDUFA12.
DR   Pfam; PF05071; NDUFA12; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Chaperone; Mitochondrion; Reference proteome.
FT   CHAIN           1..237
FT                   /note="NADH-ubiquinone oxidoreductase assembly factor
FT                   N7BML"
FT                   /id="PRO_0000433340"
FT   REGION          214..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   STRAND          44..46
FT                   /evidence="ECO:0007829|PDB:6RFQ"
FT   STRAND          48..53
FT                   /evidence="ECO:0007829|PDB:6RFQ"
FT   STRAND          63..66
FT                   /evidence="ECO:0007829|PDB:6RFQ"
FT   HELIX           81..87
FT                   /evidence="ECO:0007829|PDB:6RFQ"
FT   HELIX           97..120
FT                   /evidence="ECO:0007829|PDB:6RFQ"
SQ   SEQUENCE   237 AA;  27603 MW;  3CCA440C99A00B72 CRC64;
     MIPTPVLRFN PIADKVPKWK RIYHKWRGIQ NMPFKSKYFV GYDLDGNSYW EFKNVNNPGR
     YRRIVEPAKP DLSLVDHKIP PQWVQWLRFT RPHHPTLEEL IADKQRQELL QAKIAAYEAK
     WKEIPLKTAE NADESRDMSL EDQLKPTFTE AELAEMAQVF EKVPQQAAPA PPRVPNMAAI
     EVEDIIKHYP ENGPDTVLAD GGRQRDHDLK MDYVEKERDD SGKPAEWTPK AAVRRRG