N7BM_YARLI
ID N7BM_YARLI Reviewed; 138 AA.
AC Q6CG53;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit N7BM {ECO:0000305|PubMed:15282186};
DE AltName: Full=NADH-ubiquinone oxidoreductase subunit N7BM;
GN Name=N7BM {ECO:0000303|PubMed:15282186}; OrderedLocusNames=YALI0B00792g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
RN [2]
RP SUBUNIT, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=15282186; DOI=10.1016/j.bbabio.2004.04.019;
RA Abdrakhmanova A., Zickermann V., Bostina M., Radermacher M., Schagger H.,
RA Kerscher S., Brandt U.;
RT "Subunit composition of mitochondrial complex I from the yeast Yarrowia
RT lipolytica.";
RL Biochim. Biophys. Acta 1658:148-156(2004).
RN [3]
RP SUBUNIT, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18762163; DOI=10.1016/j.bbabio.2008.08.001;
RA Morgner N., Zickermann V., Kerscher S., Wittig I., Abdrakhmanova A.,
RA Barth H.D., Brutschy B., Brandt U.;
RT "Subunit mass fingerprinting of mitochondrial complex I.";
RL Biochim. Biophys. Acta 1777:1384-1391(2008).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O97725}.
CC -!- SUBUNIT: Complex I is composed of 42 different subunits.
CC {ECO:0000269|PubMed:15282186, ECO:0000269|PubMed:18762163}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O97725}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O97725}; Matrix side
CC {ECO:0000250|UniProtKB:O97725}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA12 subunit family.
CC {ECO:0000305}.
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DR EMBL; CR382128; CAG82573.1; -; Genomic_DNA.
DR RefSeq; XP_500359.1; XM_500359.1.
DR PDB; 6GCS; EM; 4.32 A; h=1-138.
DR PDB; 6RFR; EM; 3.20 A; h=1-138.
DR PDB; 6RFS; EM; 4.04 A; h=1-138.
DR PDB; 6Y79; EM; 3.20 A; h=1-138.
DR PDB; 6YJ4; EM; 2.70 A; f=1-138.
DR PDBsum; 6GCS; -.
DR PDBsum; 6RFR; -.
DR PDBsum; 6RFS; -.
DR PDBsum; 6Y79; -.
DR PDBsum; 6YJ4; -.
DR AlphaFoldDB; Q6CG53; -.
DR SMR; Q6CG53; -.
DR IntAct; Q6CG53; 1.
DR STRING; 4952.CAG82573; -.
DR EnsemblFungi; CAG82573; CAG82573; YALI0_B00792g.
DR GeneID; 2907560; -.
DR KEGG; yli:YALI0B00792g; -.
DR VEuPathDB; FungiDB:YALI0_B00792g; -.
DR HOGENOM; CLU_110455_2_1_1; -.
DR InParanoid; Q6CG53; -.
DR OMA; WHGWIHH; -.
DR Proteomes; UP000001300; Chromosome B.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR InterPro; IPR007763; NDUFA12.
DR PANTHER; PTHR12910; PTHR12910; 1.
DR Pfam; PF05071; NDUFA12; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transport.
FT CHAIN 1..138
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit N7BM"
FT /id="PRO_0000433341"
FT HELIX 5..14
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 17..26
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 34..38
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 44..47
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 58..62
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 64..67
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 70..72
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 77..80
FT /evidence="ECO:0007829|PDB:6YJ4"
FT TURN 81..83
FT /evidence="ECO:0007829|PDB:6YJ4"
FT TURN 89..91
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 94..97
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 111..113
FT /evidence="ECO:0007829|PDB:6RFR"
SQ SEQUENCE 138 AA; 16153 MW; D4AC33F0D81BE2B7 CRC64;
MSSSLYRVLR NAWEVGPRSY WKQLNSIGDT KSGRLVGTDI YGNKFYETDH QDEIHLRTRY
VEYKEKDYDM SQVEPGWHFW LGYGVDTAPC NTPKEKLPIR AYPYKFQPNY TGTPGAFVTY
NTLKPKISAW EPVTKQRS
