ID   NA111_ANEVI             Reviewed;          81 AA.
AC   P0DMZ1;
DT   16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Delta-actitoxin-Avd1h {ECO:0000303|PubMed:22683676};
DE            Short=Delta-AITX-Avd1h {ECO:0000303|PubMed:22683676};
DE   AltName: Full=Neurotoxin 1-1 {ECO:0000303|PubMed:21281459};
DE   Flags: Precursor;
OS   Anemonia viridis (Snakelocks anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Anemonia.
OX   NCBI_TaxID=51769;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=19627569; DOI=10.1186/1471-2164-10-333;
RA   Sabourault C., Ganot P., Deleury E., Allemand D., Furla P.;
RT   "Comprehensive EST analysis of the symbiotic sea anemone, Anemonia
RT   viridis.";
RL   BMC Genomics 10:333-333(2009).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=21281459; DOI=10.1186/1471-2164-12-88;
RA   Kozlov S., Grishin E.;
RT   "The mining of toxin-like polypeptides from EST database by single residue
RT   distribution analysis.";
RL   BMC Genomics 12:88-88(2011).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA   Oliveira J.S., Fuentes-Silva D., King G.F.;
RT   "Development of a rational nomenclature for naming peptide and protein
RT   toxins from sea anemones.";
RL   Toxicon 60:539-550(2012).
CC   -!- FUNCTION: Binds specifically to voltage-gated sodium channels (Nav) and
CC       delays their inactivation during signal transduction (when tested on
CC       the soma membrane of a crustacean neuron). Has also been observed to
CC       affect the activation of the sodium current.
CC       {ECO:0000250|UniProtKB:P01533}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Nematocyst {ECO:0000305}.
CC   -!- MISCELLANEOUS: Does not have effect on potassium or calcium currents
CC       with concentrations up to 5 uM. Is inactive at excitable membranes of
CC       frog. {ECO:0000250|UniProtKB:P01533}.
CC   -!- SIMILARITY: Belongs to the sea anemone sodium channel inhibitory toxin
CC       family. Type I subfamily. {ECO:0000305}.
CC   -!- CAUTION: Opinions are divided on whether Anemonia viridis (Forsskal,
CC       1775) and Anemonia sulcata (Pennant, 1777) are separate species.
CC       {ECO:0000305}.
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DR   EMBL; FK754096; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; FK728784; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0DMZ1; -.
DR   SMR; P0DMZ1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.20.10; -; 1.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Nematocyst; Neurotoxin; Secreted; Signal;
KW   Toxin; Voltage-gated sodium channel impairing toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..33
FT                   /evidence="ECO:0000250|UniProtKB:P01533"
FT                   /id="PRO_0000433678"
FT   CHAIN           36..81
FT                   /note="Delta-actitoxin-Avd1h"
FT                   /evidence="ECO:0000250|UniProtKB:P01533"
FT                   /id="PRO_0000433679"
FT   DISULFID        39..78
FT                   /evidence="ECO:0000250|UniProtKB:P01533"
FT   DISULFID        41..69
FT                   /evidence="ECO:0000250|UniProtKB:P01533"
FT   DISULFID        62..79
FT                   /evidence="ECO:0000250|UniProtKB:P01533"
SQ   SEQUENCE   81 AA;  8780 MW;  EF793202675021C5 CRC64;
     MMNRLLVFLM LGAAFMLVVS AIDQDANEDV NMVKRGAPCL CKSDGPNTRG NSMSGTIWVF
     GCPSGWNDCE GRAIIGYCCK Q