NA11_ANEER
ID NA11_ANEER Reviewed; 47 AA.
AC P69943;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 25-MAY-2022, entry version 50.
DE RecName: Full=Delta-actitoxin-Aer1a {ECO:0000303|PubMed:22683676};
DE Short=Delta-AITX-Aer1a {ECO:0000303|PubMed:22683676};
DE AltName: Full=AETX I {ECO:0000303|PubMed:9133656};
DE AltName: Full=Toxin AETX-1 {ECO:0000305};
OS Anemonia erythraea (Sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Actiniidae; Anemonia.
OX NCBI_TaxID=48400;
RN [1]
RP PROTEIN SEQUENCE, MASS SPECTROMETRY, AND TOXIC DOSE.
RC STRAIN=Banda, and Chojagasaki; TISSUE=Nematoblast;
RX PubMed=9133656; DOI=10.1016/s0304-4165(96)00137-7;
RA Shiomi K., Qian W.-H., Lin X.-Y., Shimakura K., Nagashima Y., Ishida M.;
RT "Novel polypeptide toxins with crab lethality from the sea anemone Anemonia
RT erythraea.";
RL Biochim. Biophys. Acta 1335:191-198(1997).
RN [2]
RP NOMENCLATURE.
RX PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA Oliveira J.S., Fuentes-Silva D., King G.F.;
RT "Development of a rational nomenclature for naming peptide and protein
RT toxins from sea anemones.";
RL Toxicon 60:539-550(2012).
CC -!- FUNCTION: Binds specifically to voltage-gated sodium channels (Nav),
CC thereby delaying their inactivation during signal transduction.
CC {ECO:0000250|UniProtKB:P01533}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Nematocyst {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=4958; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:9133656};
CC -!- TOXIC DOSE: LD(50) is 2.2 ug/kg to crabs. {ECO:0000269|PubMed:9133656}.
CC -!- SIMILARITY: Belongs to the sea anemone sodium channel inhibitory toxin
CC family. Type I subfamily. {ECO:0000305}.
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DR AlphaFoldDB; P69943; -.
DR SMR; P69943; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR Gene3D; 2.20.20.10; -; 1.
DR InterPro; IPR000693; Anenome_toxin.
DR InterPro; IPR023355; Myo_ane_neurotoxin_sf.
DR PIRSF; PIRSF001905; Anenome_toxin; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW Nematocyst; Neurotoxin; Secreted; Toxin;
KW Voltage-gated sodium channel impairing toxin.
FT CHAIN 1..47
FT /note="Delta-actitoxin-Aer1a"
FT /evidence="ECO:0000269|PubMed:9133656"
FT /id="PRO_0000221511"
FT DISULFID 4..43
FT /evidence="ECO:0000250|UniProtKB:P01533"
FT DISULFID 6..34
FT /evidence="ECO:0000250|UniProtKB:P01533"
FT DISULFID 27..44
FT /evidence="ECO:0000250|UniProtKB:P01533"
SQ SEQUENCE 47 AA; 4970 MW; 0DAA0F42EA116C21 CRC64;
GAPCLCANSG PNTRGNDLNG IVWVFGCPSG WHDCHGRAMV GYCCQED
