ID   NA11_CONGI              Reviewed;          47 AA.
AC   P0CH42;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Delta-actitoxin-Cps1a {ECO:0000303|PubMed:22683676};
DE            Short=Delta-AITX-Cps1a {ECO:0000303|PubMed:22683676};
DE   AltName: Full=Cp-1 {ECO:0000305};
DE            Short=Cp I {ECO:0000303|Ref.1};
DE            Short=CpI {ECO:0000303|PubMed:19393679};
OS   Condylactis gigantea (Giant Caribbean anemone) (Condylactis passiflora).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Condylactis.
OX   NCBI_TaxID=47073;
RN   [1]
RP   PROTEIN SEQUENCE, AND HYDROXYLATION AT PRO-3.
RA   Shiomi K., Lin X.Y., Nagashima Y., Ishida M.;
RT   "Isolation and amino acid sequences of polypeptide toxins in the Caribbean
RT   sea anemone Condylactis passiflora.";
RL   Fish. Sci. 61:1016-1021(1995).
RN   [2]
RP   REVIEW.
RX   PubMed=19393679; DOI=10.1016/j.toxicon.2009.04.018;
RA   Wanke E., Zaharenko A.J., Redaelli E., Schiavon E.;
RT   "Actions of sea anemone type 1 neurotoxins on voltage-gated sodium channel
RT   isoforms.";
RL   Toxicon 54:1102-1111(2009).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA   Oliveira J.S., Fuentes-Silva D., King G.F.;
RT   "Development of a rational nomenclature for naming peptide and protein
RT   toxins from sea anemones.";
RL   Toxicon 60:539-550(2012).
CC   -!- FUNCTION: Binds voltage-dependently at site 3 of sodium channels (Nav)
CC       and inhibits the inactivation, thereby blocking neuronal transmission
CC       (By similarity). The minimum lethal dose against crabs is 7.3 mg/kg
CC       (Ref.1). {ECO:0000250, ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Nematocyst {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sea anemone sodium channel inhibitory toxin
CC       family. Type I subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0CH42; -.
DR   SMR; P0CH42; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.20.10; -; 1.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydroxylation;
KW   Ion channel impairing toxin; Nematocyst; Secreted; Toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..47
FT                   /note="Delta-actitoxin-Cps1a"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000397963"
FT   MOD_RES         3
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000269|Ref.1"
FT   DISULFID        4..44
FT                   /evidence="ECO:0000250|UniProtKB:P0C280"
FT   DISULFID        6..34
FT                   /evidence="ECO:0000250|UniProtKB:P0C280"
FT   DISULFID        27..45
FT                   /evidence="ECO:0000250|UniProtKB:P0C280"
SQ   SEQUENCE   47 AA;  5047 MW;  B095184616759A10 CRC64;
     GVPCRCDSDG PSVHGNTLSG TVWVGSCASG WHKCNTEHNI FHECCKE