ID   NA11_HETCR              Reviewed;          47 AA.
AC   P0C5G5;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Delta-stichotoxin-Hcr3a {ECO:0000303|PubMed:22683676};
DE            Short=Delta-SHTX-Hcr3a {ECO:0000303|PubMed:22683676};
DE   AltName: Full=Rc-I;
DE            Short=Rc I {ECO:0000303|Ref.1};
DE            Short=Rc-1;
OS   Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Stichodactylidae; Heteractis.
OX   NCBI_TaxID=175771;
RN   [1]
RP   PROTEIN SEQUENCE, AND HYDROXYLATION AT PRO-3.
RA   Shiomi K., Lin X.Y., Nagashima Y., Ishida M.;
RT   "Isolation and amino acid sequence of a polypeptide toxin from the sea
RT   anemone Radianthus crispus.";
RL   Fish. Sci. 62:629-633(1996).
RN   [2]
RP   REVIEW.
RX   PubMed=16372161; DOI=10.1007/s10126-005-5093-2;
RA   Honma T., Shiomi K.;
RT   "Peptide toxins in sea anemones: structural and functional aspects.";
RL   Mar. Biotechnol. 8:1-10(2006).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA   Oliveira J.S., Fuentes-Silva D., King G.F.;
RT   "Development of a rational nomenclature for naming peptide and protein
RT   toxins from sea anemones.";
RL   Toxicon 60:539-550(2012).
CC   -!- FUNCTION: Inhibits voltage-gated sodium channels (Nav).
CC       {ECO:0000250|UniProtKB:P0C280}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Nematocyst {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sea anemone sodium channel inhibitory toxin
CC       family. Type I subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C5G5; -.
DR   SMR; P0C5G5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.20.10; -; 1.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydroxylation;
KW   Ion channel impairing toxin; Nematocyst; Neurotoxin; Secreted; Toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..47
FT                   /note="Delta-stichotoxin-Hcr3a"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000305119"
FT   MOD_RES         3
FT                   /note="Hydroxyproline"
FT                   /evidence="ECO:0000269|Ref.1"
FT   DISULFID        4..44
FT                   /evidence="ECO:0000250|UniProtKB:P0C280"
FT   DISULFID        6..34
FT                   /evidence="ECO:0000250|UniProtKB:P0C280"
FT   DISULFID        27..45
FT                   /evidence="ECO:0000250|UniProtKB:P0C280"
SQ   SEQUENCE   47 AA;  5132 MW;  EC4BECAE2BB59A17 CRC64;
     GVPCRCDSDG PSVHGNTLSG TIWVGSCETG WHKCNTEHNL FHECCKQ