ID   NA122_ACTEQ             Reviewed;          82 AA.
AC   B1NWU3;
DT   22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Delta-actitoxin-Aeq2b 2 {ECO:0000303|PubMed:22683676};
DE            Short=Delta-AITX-Aeq2b 2 {ECO:0000303|PubMed:22683676};
DE   AltName: Full=Ae2-2 {ECO:0000303|PubMed:18222944};
DE   AltName: Full=Neurotoxin 2-2 {ECO:0000312|EMBL:ABW97359.1};
DE   Flags: Precursor;
OS   Actinia equina (Beadlet anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Actinia.
OX   NCBI_TaxID=6106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=18222944; DOI=10.1093/molbev/msn021;
RA   Moran Y., Weinberger H., Sullivan J.C., Reitzel A.M., Finnerty J.R.,
RA   Gurevitz M.;
RT   "Concerted evolution of sea anemone neurotoxin genes is revealed through
RT   analysis of the Nematostella vectensis genome.";
RL   Mol. Biol. Evol. 25:737-747(2008).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA   Oliveira J.S., Fuentes-Silva D., King G.F.;
RT   "Development of a rational nomenclature for naming peptide and protein
RT   toxins from sea anemones.";
RL   Toxicon 60:539-550(2012).
CC   -!- FUNCTION: Binds specifically to voltage-gated sodium channels (Nav),
CC       thereby delaying their inactivation during signal transduction. Causes
CC       death to crabs. {ECO:0000250|UniProtKB:Q9NJQ2}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Nematocyst {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sea anemone sodium channel inhibitory toxin
CC       family. Type I subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EU124480; ABW97359.1; -; Genomic_DNA.
DR   AlphaFoldDB; B1NWU3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.20.10; -; 1.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Nematocyst; Neurotoxin; Secreted; Signal;
KW   Toxin; Voltage-gated sodium channel impairing toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..26
FT                   /evidence="ECO:0000250|UniProtKB:Q9NJQ2"
FT                   /id="PRO_0000433576"
FT   CHAIN           29..82
FT                   /note="Delta-actitoxin-Aeq2b 2"
FT                   /evidence="ECO:0000250|UniProtKB:P01530"
FT                   /id="PRO_5000319687"
FT   DISULFID        32..79
FT                   /evidence="ECO:0000250|UniProtKB:P01530"
FT   DISULFID        34..69
FT                   /evidence="ECO:0000250|UniProtKB:P01530"
FT   DISULFID        62..80
FT                   /evidence="ECO:0000250|UniProtKB:P01530"
SQ   SEQUENCE   82 AA;  8859 MW;  BA3C63A25D9FBB02 CRC64;
     MNRLMILVFA AVFLALASAD EDVDIAKRGV PCLCVSDGPR PRGNNLSGIM WMKTGGYGGN
     GCPKGWHFCG KSRGFFSDCC KR