NA12D_ANEVI
ID NA12D_ANEVI Reviewed; 79 AA.
AC B1NWT7;
DT 16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 36.
DE RecName: Full=Delta-actitoxin-Avd1c 4 {ECO:0000303|PubMed:22683676};
DE Short=Delta-AITX-Avd1c 4 {ECO:0000303|PubMed:22683676};
DE AltName: Full=Toxin 2c2 {ECO:0000312|EMBL:ABW97353.1};
DE AltName: Full=Toxin 2c3 {ECO:0000312|EMBL:ABW97354.1};
DE Flags: Precursor;
OS Anemonia viridis (Snakelocks anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Actiniidae; Anemonia.
OX NCBI_TaxID=51769;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=18222944; DOI=10.1093/molbev/msn021;
RA Moran Y., Weinberger H., Sullivan J.C., Reitzel A.M., Finnerty J.R.,
RA Gurevitz M.;
RT "Concerted evolution of sea anemone neurotoxin genes is revealed through
RT analysis of the Nematostella vectensis genome.";
RL Mol. Biol. Evol. 25:737-747(2008).
RN [2]
RP NOMENCLATURE.
RX PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA Oliveira J.S., Fuentes-Silva D., King G.F.;
RT "Development of a rational nomenclature for naming peptide and protein
RT toxins from sea anemones.";
RL Toxicon 60:539-550(2012).
CC -!- FUNCTION: Binds specifically to voltage-gated sodium channels (Nav)
CC (site 3), thereby delaying their inactivation during signal
CC transduction. Has a strong effect on crustaceans and insects and a
CC weaker effect on mammals. It strongly inhibits D.melanogaster sodium
CC channel (DmNav1). It weakly inhibits the brain sodium channel
CC Nav1.2/SCN2A. It strongly affects the heart sodium channels
CC (Nav1.5/SCN5A). {ECO:0000250|UniProtKB:P01528}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Nematocyst {ECO:0000305}.
CC -!- MISCELLANEOUS: This protein is encoded by at least 3 different genes.
CC At least 3 other genes code for a similar Av2 with an Ile (instead a
CC Val) at position 34. {ECO:0000250|UniProtKB:P0DL49}.
CC -!- SIMILARITY: Belongs to the sea anemone sodium channel inhibitory toxin
CC family. Type I subfamily. {ECO:0000305}.
CC -!- CAUTION: Opinions are divided on whether Anemonia viridis (Forsskal,
CC 1775) and Anemonia sulcata (Pennant, 1777) are separate species.
CC {ECO:0000305}.
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DR EMBL; EU124474; ABW97353.1; -; mRNA.
DR EMBL; EU124475; ABW97354.1; -; mRNA.
DR AlphaFoldDB; B1NWT7; -.
DR SMR; B1NWT7; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 2.20.20.10; -; 1.
DR InterPro; IPR023355; Myo_ane_neurotoxin_sf.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues; Disulfide bond;
KW Ion channel impairing toxin; Nematocyst; Neurotoxin; Secreted; Signal;
KW Toxin; Voltage-gated sodium channel impairing toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..30
FT /evidence="ECO:0000250|UniProtKB:P01528"
FT /id="PRO_0000433685"
FT CHAIN 33..79
FT /note="Delta-actitoxin-Avd1c 4"
FT /evidence="ECO:0000250|UniProtKB:P0DL49"
FT /id="PRO_5000319682"
FT DISULFID 36..76
FT /evidence="ECO:0000250|UniProtKB:P01528"
FT DISULFID 38..66
FT /evidence="ECO:0000250|UniProtKB:P01528"
FT DISULFID 59..77
FT /evidence="ECO:0000250|UniProtKB:P01528"
SQ SEQUENCE 79 AA; 8534 MW; D638145476163328 CRC64;
MMNRLLVFLM LGAAFMLVVS AIDQDANDIN KRGVPCLCDS DGPSVRGNTL SGIIWLAGCP
SGWHNCKKHG PTIGWCCKQ
