ID   NA12_ANTXA              Reviewed;          47 AA.
AC   P0C5F9;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Delta-actitoxin-Axm1e {ECO:0000303|PubMed:22683676};
DE            Short=Delta-AITX-Axm1e {ECO:0000303|PubMed:22683676};
DE   AltName: Full=PCR2-5 {ECO:0000303|PubMed:9604281};
DE   AltName: Full=Toxin PCR2 {ECO:0000305};
OS   Anthopleura xanthogrammica (Giant green sea anemone) (Actinia
OS   xanthogrammica).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Anthopleura.
OX   NCBI_TaxID=6112;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Tentacle;
RX   PubMed=9604281; DOI=10.1016/s0041-0101(97)00064-0;
RA   Kelso G.J., Blumenthal K.M.;
RT   "Identification and characterization of novel sodium channel toxins from
RT   the sea anemone Anthopleura xanthogrammica.";
RL   Toxicon 36:41-51(1998).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA   Oliveira J.S., Fuentes-Silva D., King G.F.;
RT   "Development of a rational nomenclature for naming peptide and protein
RT   toxins from sea anemones.";
RL   Toxicon 60:539-550(2012).
CC   -!- FUNCTION: Binds specifically to voltage-gated sodium channels (Nav),
CC       thereby delaying their inactivation. This toxin is active on a variety
CC       of voltage-gated sodium channels (Nav1.1/SCN1A, Nav1.2/SCN2A,
CC       Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A and Nav1.6/SCN8A).
CC       {ECO:0000250|UniProtKB:P10454}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P10454}.
CC       Nematocyst {ECO:0000250|UniProtKB:P10454}.
CC   -!- SIMILARITY: Belongs to the sea anemone sodium channel inhibitory toxin
CC       family. Type I subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P0C5F9; -.
DR   SMR; P0C5F9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR   Gene3D; 2.20.20.10; -; 1.
DR   InterPro; IPR000693; Anenome_toxin.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
DR   PIRSF; PIRSF001905; Anenome_toxin; 1.
PE   2: Evidence at transcript level;
KW   Cardiotoxin; Disulfide bond; Ion channel impairing toxin; Nematocyst;
KW   Neurotoxin; Secreted; Toxin; Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..47
FT                   /note="Delta-actitoxin-Axm1e"
FT                   /id="PRO_0000305113"
FT   DISULFID        4..44
FT                   /evidence="ECO:0000250|UniProtKB:P10454"
FT   DISULFID        6..34
FT                   /evidence="ECO:0000250|UniProtKB:P10454"
FT   DISULFID        27..45
FT                   /evidence="ECO:0000250|UniProtKB:P10454"
SQ   SEQUENCE   47 AA;  4773 MW;  29302E7009E4CD97 CRC64;
     GVACLCDADG PSVSGNTLSG ILWLAGCPSG WHNCKAHGPT IGWCCKK