NA13_ANTEL
ID NA13_ANTEL Reviewed; 47 AA.
AC P0C1F1;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Delta-actitoxin-Ael1c {ECO:0000303|PubMed:22683676};
DE Short=Delta-AITX-Ael1c {ECO:0000303|PubMed:22683676};
DE AltName: Full=Toxin APE 1-2 {ECO:0000303|PubMed:11072049};
OS Anthopleura elegantissima (Green aggregating anemone) (Actinia
OS elegantissima).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Actiniidae; Anthopleura.
OX NCBI_TaxID=6110;
RN [1]
RP PROTEIN SEQUENCE, AND FUNCTION.
RX PubMed=11072049; DOI=10.1016/s0041-0101(00)00199-9;
RA Bruhn T., Schaller C., Schulze C., Sanchez-Rodriguez J., Dannmeier C.,
RA Ravens U., Heubach J.F., Eckhardt K., Schmidtmayer J., Schmidt H.,
RA Aneiros A., Wachter E., Beress L.;
RT "Isolation and characterisation of five neurotoxic and cardiotoxic
RT polypeptides from the sea anemone Anthopleura elegantissima.";
RL Toxicon 39:693-702(2001).
RN [2]
RP NOMENCLATURE.
RX PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA Oliveira J.S., Fuentes-Silva D., King G.F.;
RT "Development of a rational nomenclature for naming peptide and protein
RT toxins from sea anemones.";
RL Toxicon 60:539-550(2012).
CC -!- FUNCTION: Modifies current passing through the fast sodium channel
CC (Nav) in neuroblastoma cells, leading to delayed and incomplete
CC inactivation. Paralyzes the shore crab (C.maenas) by tetanic
CC contractions after intramuscular injection.
CC {ECO:0000269|PubMed:11072049}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Nematocyst {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the sea anemone sodium channel inhibitory toxin
CC family. Type I subfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0C1F1; -.
DR SMR; P0C1F1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR Gene3D; 2.20.20.10; -; 1.
DR InterPro; IPR000693; Anenome_toxin.
DR InterPro; IPR023355; Myo_ane_neurotoxin_sf.
DR PIRSF; PIRSF001905; Anenome_toxin; 1.
PE 1: Evidence at protein level;
KW Cardiotoxin; Direct protein sequencing; Disulfide bond;
KW Ion channel impairing toxin; Nematocyst; Neurotoxin; Secreted; Toxin;
KW Voltage-gated sodium channel impairing toxin.
FT CHAIN 1..47
FT /note="Delta-actitoxin-Ael1c"
FT /evidence="ECO:0000269|PubMed:11072049"
FT /id="PRO_0000236025"
FT DISULFID 4..44
FT /evidence="ECO:0000250|UniProtKB:P10453"
FT DISULFID 6..34
FT /evidence="ECO:0000250|UniProtKB:P10453"
FT DISULFID 27..45
FT /evidence="ECO:0000250|UniProtKB:P10453"
SQ SEQUENCE 47 AA; 4811 MW; 621EAF4F4A0F29DD CRC64;
GVPCLCDSDG PNVRGNTLSG TYWLAGCPSG WHNCKSSGPL IGACCKQ