ID   NA16_ANEVI              Reviewed;          72 AA.
AC   B1NWT3;
DT   16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=U-actitoxin-Avd1f {ECO:0000303|PubMed:22683676};
DE            Short=U-AITX-Avd1f {ECO:0000303|PubMed:22683676};
DE   AltName: Full=Av6 {ECO:0000303|PubMed:18222944};
DE   AltName: Full=Neurotoxin 6 {ECO:0000312|EMBL:ABW97349.1};
DE   Flags: Precursor;
OS   Anemonia viridis (Snakelocks anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Anemonia.
OX   NCBI_TaxID=51769;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=18222944; DOI=10.1093/molbev/msn021;
RA   Moran Y., Weinberger H., Sullivan J.C., Reitzel A.M., Finnerty J.R.,
RA   Gurevitz M.;
RT   "Concerted evolution of sea anemone neurotoxin genes is revealed through
RT   analysis of the Nematostella vectensis genome.";
RL   Mol. Biol. Evol. 25:737-747(2008).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA   Oliveira J.S., Fuentes-Silva D., King G.F.;
RT   "Development of a rational nomenclature for naming peptide and protein
RT   toxins from sea anemones.";
RL   Toxicon 60:539-550(2012).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Nematocyst {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sea anemone sodium channel inhibitory toxin
CC       family. Type I subfamily. {ECO:0000305}.
CC   -!- CAUTION: Opinions are divided on whether Anemonia viridis (Forsskal,
CC       1775) and Anemonia sulcata (Pennant, 1777) are separate species.
CC       {ECO:0000305}.
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DR   EMBL; EU124470; ABW97349.1; -; Genomic_DNA.
DR   AlphaFoldDB; B1NWT3; -.
DR   TCDB; 8.B.17.1.4; the sea anemone peptide toxin class iii (shi) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.20.10; -; 1.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Nematocyst; Neurotoxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..32
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000433687"
FT   CHAIN           35..72
FT                   /note="U-actitoxin-Avd1f"
FT                   /id="PRO_5000319677"
FT   DISULFID        38..69
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..62
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..70
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   72 AA;  7989 MW;  5D4A7C211A8E048E CRC64;
     MMNRLLVFLM LGAAFMLVVS AIDQDANEDV NMKRGLPCKC DGDKHMSGTF WMFGCPPGWH
     SCVVANAFCC KQ