NA1C3_BUNCN
ID NA1C3_BUNCN Reviewed; 48 AA.
AC P0C7Q0;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 25-MAY-2022, entry version 34.
DE RecName: Full=Delta-actitoxin-Bcg1c {ECO:0000303|PubMed:22683676};
DE Short=Delta-AITX-Bcg1c {ECO:0000303|PubMed:22683676};
DE AltName: Full=Cangitoxin III {ECO:0000303|PubMed:18342901};
DE AltName: Full=Cangitoxin-3 {ECO:0000305};
DE AltName: Full=Cangitoxin-III;
DE Short=CGTX-III {ECO:0000303|PubMed:18342901};
OS Bunodosoma cangicum (Sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Actiniidae; Bunodosoma.
OX NCBI_TaxID=138296;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC TISSUE=Nematoblast;
RX PubMed=18342901; DOI=10.1016/j.toxicon.2008.01.011;
RA Zaharenko A.J., Ferreira W.A. Jr., de Oliveira J.S., Konno K.,
RA Richardson M., Schiavon E., Wanke E., de Freitas J.C.;
RT "Revisiting cangitoxin, a sea anemone peptide: purification and
RT characterization of cangitoxins II and III from the venom of Bunodosoma
RT cangicum.";
RL Toxicon 51:1303-1307(2008).
RN [2]
RP NOMENCLATURE.
RX PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA Oliveira J.S., Fuentes-Silva D., King G.F.;
RT "Development of a rational nomenclature for naming peptide and protein
RT toxins from sea anemones.";
RL Toxicon 60:539-550(2012).
CC -!- FUNCTION: Binds specifically to voltage-gated sodium channels
CC SCN1A/Nav1.1, thereby delaying their inactivation during signal
CC transduction. {ECO:0000269|PubMed:18342901}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18342901}.
CC Nematocyst {ECO:0000269|PubMed:18342901}.
CC -!- MASS SPECTROMETRY: Mass=4939.07; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:18342901};
CC -!- SIMILARITY: Belongs to the sea anemone sodium channel inhibitory toxin
CC family. Type I subfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0C7Q0; -.
DR SMR; P0C7Q0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR Gene3D; 2.20.20.10; -; 1.
DR InterPro; IPR000693; Anenome_toxin.
DR InterPro; IPR023355; Myo_ane_neurotoxin_sf.
DR PIRSF; PIRSF001905; Anenome_toxin; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW Nematocyst; Neurotoxin; Secreted; Toxin;
KW Voltage-gated sodium channel impairing toxin.
FT CHAIN 1..48
FT /note="Delta-actitoxin-Bcg1c"
FT /evidence="ECO:0000269|PubMed:18342901"
FT /id="PRO_0000342624"
FT DISULFID 4..45
FT /evidence="ECO:0000250"
FT DISULFID 6..35
FT /evidence="ECO:0000250"
FT DISULFID 28..46
FT /evidence="ECO:0000250"
SQ SEQUENCE 48 AA; 4945 MW; E686E4B4CE01F456 CRC64;
GVACRCDSDG PTVHGDSLSG TLWLTGGCPS GWHNCRGSGP FIGYCCKK
