ID   NA21_HETCR              Reviewed;          48 AA.
AC   P30831;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Delta-stichotoxin-Hcr1e {ECO:0000303|PubMed:22683676};
DE            Short=Delta-SHTX-Hcr1e {ECO:0000303|PubMed:22683676};
DE   AltName: Full=Neurotoxin I {ECO:0000303|PubMed:2576625};
DE   AltName: Full=RTX-I;
DE   AltName: Full=Rm1;
OS   Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Stichodactylidae; Heteractis.
OX   NCBI_TaxID=175771;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Nematoblast;
RX   PubMed=2576625;
RA   Zykova T.A., Kozlovskaya E.P.;
RT   "Amino acid sequence of a neurotoxin from the anemone Radianthus
RT   macrodactylus.";
RL   Bioorg. Khim. 15:1301-1306(1989).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA   Oliveira J.S., Fuentes-Silva D., King G.F.;
RT   "Development of a rational nomenclature for naming peptide and protein
RT   toxins from sea anemones.";
RL   Toxicon 60:539-550(2012).
CC   -!- FUNCTION: Binds to site 3 of voltage-gated sodium channels and inhibits
CC       the inactivation process. {ECO:0000250|UniProtKB:P30832}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2576625}.
CC       Nematocyst.
CC   -!- SIMILARITY: Belongs to the sea anemone sodium channel inhibitory toxin
CC       family. Type II subfamily. {ECO:0000305}.
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DR   PIR; JN0355; JN0355.
DR   AlphaFoldDB; P30831; -.
DR   SMR; P30831; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR   Gene3D; 2.20.20.10; -; 1.
DR   InterPro; IPR000693; Anenome_toxin.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
DR   PIRSF; PIRSF001905; Anenome_toxin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Nematocyst; Neurotoxin; Secreted; Toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   CHAIN           1..48
FT                   /note="Delta-stichotoxin-Hcr1e"
FT                   /evidence="ECO:0000269|PubMed:2576625"
FT                   /id="PRO_0000221522"
FT   DISULFID        3..43
FT                   /evidence="ECO:0000250|UniProtKB:P19651"
FT   DISULFID        5..33
FT                   /evidence="ECO:0000250|UniProtKB:P19651"
FT   DISULFID        26..44
FT                   /evidence="ECO:0000250|UniProtKB:P19651"
SQ   SEQUENCE   48 AA;  5183 MW;  555A0F0E8C990817 CRC64;
     ASCKCDDDGP DVRSATFTGT VDFAYCNAGW EKCLAVYTPV ASCCRKKK