ID   NA2G3_STIGI             Reviewed;          84 AA.
AC   Q76CA0;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Delta-stichotoxin-Sgt3a {ECO:0000303|PubMed:22683676};
DE            Short=Delta-SHTX-Sgt3a {ECO:0000303|PubMed:22683676};
DE   AltName: Full=Gigantoxin III {ECO:0000303|PubMed:12565742};
DE            Short=Gigt III;
DE   AltName: Full=Gigantoxin-3 {ECO:0000305};
DE   Flags: Precursor;
OS   Stichodactyla gigantea (Giant carpet anemone) (Gigantic sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Stichodactylidae; Stichodactyla.
OX   NCBI_TaxID=230562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14644045; DOI=10.1016/j.bbapap.2003.08.007;
RA   Honma T., Nagai H., Nagashima Y., Shiomi K.;
RT   "Molecular cloning of an epidermal growth factor-like toxin and two sodium
RT   channel toxins from the sea anemone Stichodactyla gigantea.";
RL   Biochim. Biophys. Acta 1652:103-106(2003).
RN   [2]
RP   PROTEIN SEQUENCE OF 36-83, AND TOXIC DOSE.
RC   TISSUE=Nematoblast;
RX   PubMed=12565742; DOI=10.1016/s0041-0101(02)00281-7;
RA   Shiomi K., Honma T., Ide M., Nagashima Y., Ishida M., Chino M.;
RT   "An epidermal growth factor-like toxin and two sodium channel toxins from
RT   the sea anemone Stichodactyla gigantea.";
RL   Toxicon 41:229-236(2003).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA   Oliveira J.S., Fuentes-Silva D., King G.F.;
RT   "Development of a rational nomenclature for naming peptide and protein
RT   toxins from sea anemones.";
RL   Toxicon 60:539-550(2012).
CC   -!- FUNCTION: Binds specifically to voltage-gated sodium channels (Nav),
CC       thereby delaying their inactivation during signal transduction.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:12565742}.
CC       Nematocyst {ECO:0000305}.
CC   -!- TOXIC DOSE: LD(50) is 120 ug/kg to crabs.
CC       {ECO:0000269|PubMed:12565742}.
CC   -!- SIMILARITY: Belongs to the sea anemone sodium channel inhibitory toxin
CC       family. Type II subfamily. {ECO:0000305}.
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DR   EMBL; AB110015; BAD01580.1; -; mRNA.
DR   AlphaFoldDB; Q76CA0; -.
DR   SMR; Q76CA0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.20.10; -; 1.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Ion channel impairing toxin; Nematocyst; Neurotoxin;
KW   Secreted; Signal; Toxin; Voltage-gated sodium channel impairing toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..33
FT                   /evidence="ECO:0000269|PubMed:12565742"
FT                   /id="PRO_0000034827"
FT   CHAIN           36..83
FT                   /note="Delta-stichotoxin-Sgt3a"
FT                   /evidence="ECO:0000269|PubMed:12565742"
FT                   /id="PRO_0000034828"
FT   PROPEP          84
FT                   /id="PRO_0000034829"
FT   DISULFID        38..78
FT                   /evidence="ECO:0000250|UniProtKB:P19651"
FT   DISULFID        40..68
FT                   /evidence="ECO:0000250|UniProtKB:P19651"
FT   DISULFID        61..79
FT                   /evidence="ECO:0000250|UniProtKB:P19651"
SQ   SEQUENCE   84 AA;  9103 MW;  203B4AA977D22AD2 CRC64;
     MAYLKIVLVA LMLVVAVSAM RLSDQEDQDI SVAKRAACKC DDDGPDIRSA TLTGTVDLGS
     CNEGWEKCAS FYTILADCCR RPRG