ID   NA2X_HETHE              Reviewed;          84 AA.
AC   D2KX91;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Delta-thalatoxin-Hhe1a {ECO:0000303|PubMed:22683676};
DE            Short=Delta-TATX-Hhe1a {ECO:0000303|PubMed:22683676};
DE   AltName: Full=Delta-thalatoxin-Hh1x {ECO:0000303|PubMed:20817118};
DE            Short=Delta-TLTX-Hh1x {ECO:0000303|PubMed:20817118};
DE   AltName: Full=Hh X {ECO:0000312|EMBL:BAI66463.1};
DE   Flags: Precursor;
OS   Heterodactyla hemprichii (Hemprich's sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Nynantheae; Thalassianthidae; Heterodactyla.
OX   NCBI_TaxID=659514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 36-67, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=20817118; DOI=10.1016/j.cbpb.2010.08.008;
RA   Maeda M., Honma T., Shiomi K.;
RT   "Isolation and cDNA cloning of type 2 sodium channel peptide toxins from
RT   three species of sea anemones (Cryptodendrum adhaesivum, Heterodactyla
RT   hemprichii and Thalassianthus aster) belonging to the family
RT   Thalassianthidae.";
RL   Comp. Biochem. Physiol. 157B:389-393(2010).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA   Oliveira J.S., Fuentes-Silva D., King G.F.;
RT   "Development of a rational nomenclature for naming peptide and protein
RT   toxins from sea anemones.";
RL   Toxicon 60:539-550(2012).
CC   -!- FUNCTION: Binds specifically to the voltage-gated sodium channel (Nav)
CC       and delays its inactivation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20817118}.
CC       Nematocyst {ECO:0000269|PubMed:20817118}.
CC   -!- SIMILARITY: Belongs to the sea anemone sodium channel inhibitory toxin
CC       family. Type II subfamily. {ECO:0000305}.
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DR   EMBL; AB512762; BAI66463.1; -; mRNA.
DR   AlphaFoldDB; D2KX91; -.
DR   SMR; D2KX91; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.20.10; -; 1.
DR   InterPro; IPR023355; Myo_ane_neurotoxin_sf.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Ion channel impairing toxin; Nematocyst; Neurotoxin;
KW   Secreted; Signal; Toxin; Voltage-gated sodium channel impairing toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..33
FT                   /evidence="ECO:0000269|PubMed:20817118"
FT                   /id="PRO_0000404207"
FT   CHAIN           36..84
FT                   /note="Delta-thalatoxin-Hhe1a"
FT                   /id="PRO_0000404208"
FT   DISULFID        38..78
FT                   /evidence="ECO:0000250|UniProtKB:P19651"
FT   DISULFID        40..68
FT                   /evidence="ECO:0000250|UniProtKB:P19651"
FT   DISULFID        61..79
FT                   /evidence="ECO:0000250|UniProtKB:P19651"
SQ   SEQUENCE   84 AA;  9221 MW;  CF24AAF9E088F93A CRC64;
     MAYQKIVFVA LMLVLAVSAM RLPDQQDQDI SVAKRVACKC DDDGPDIRSA TLTGTVDLGS
     CNEGWEKCAS YYTVVADCCR RPRS