A16A1_MOUSE
ID A16A1_MOUSE Reviewed; 802 AA.
AC Q571I9; Q3U6I2; Q3UMC3; Q8C0L4; Q8VD78;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Aldehyde dehydrogenase family 16 member A1;
GN Name=Aldh16a1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Bone marrow macrophage, Dendritic cell, Head, and Mammary gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Interacts with SPG21. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000305}.
CC -!- CAUTION: The active site cysteine and glutamate residues are not
CC conserved in this protein. Its activity is therefore unsure.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD90125.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK220200; BAD90125.1; ALT_INIT; mRNA.
DR EMBL; AK030673; BAC27074.1; -; mRNA.
DR EMBL; AK144995; BAE26175.1; -; mRNA.
DR EMBL; AK151691; BAE30615.1; -; mRNA.
DR EMBL; AK153129; BAE31742.1; -; mRNA.
DR EMBL; AK161198; BAE36234.1; -; mRNA.
DR EMBL; AK170276; BAE41680.1; -; mRNA.
DR EMBL; BC013548; AAH13548.2; -; mRNA.
DR CCDS; CCDS21231.1; -.
DR RefSeq; NP_666066.1; NM_145954.1.
DR AlphaFoldDB; Q571I9; -.
DR SMR; Q571I9; -.
DR BioGRID; 213654; 1.
DR IntAct; Q571I9; 3.
DR STRING; 10090.ENSMUSP00000007977; -.
DR iPTMnet; Q571I9; -.
DR PhosphoSitePlus; Q571I9; -.
DR SwissPalm; Q571I9; -.
DR EPD; Q571I9; -.
DR jPOST; Q571I9; -.
DR MaxQB; Q571I9; -.
DR PaxDb; Q571I9; -.
DR PRIDE; Q571I9; -.
DR ProteomicsDB; 285739; -.
DR ABCD; Q571I9; 5 sequenced antibodies.
DR GeneID; 69748; -.
DR KEGG; mmu:69748; -.
DR UCSC; uc009gtr.1; mouse.
DR CTD; 126133; -.
DR MGI; MGI:1916998; Aldh16a1.
DR eggNOG; KOG2450; Eukaryota.
DR InParanoid; Q571I9; -.
DR OrthoDB; 1070579at2759; -.
DR PhylomeDB; Q571I9; -.
DR TreeFam; TF329461; -.
DR BioGRID-ORCS; 69748; 3 hits in 40 CRISPR screens.
DR ChiTaRS; Aldh16a1; mouse.
DR PRO; PR:Q571I9; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q571I9; protein.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.309.10; -; 1.
DR Gene3D; 3.40.605.10; -; 2.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR011408; Aldehyde_DH.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF211; PTHR11699:SF211; 2.
DR Pfam; PF00171; Aldedh; 2.
DR PIRSF; PIRSF036490; Aldedh_dupl; 1.
DR SUPFAM; SSF53720; SSF53720; 2.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..802
FT /note="Aldehyde dehydrogenase family 16 member A1"
FT /id="PRO_0000312987"
FT CONFLICT 27
FT /note="A -> T (in Ref. 2; BAE26175)"
FT /evidence="ECO:0000305"
FT CONFLICT 166
FT /note="V -> M (in Ref. 1; BAD90125)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="V -> I (in Ref. 1; BAD90125)"
FT /evidence="ECO:0000305"
FT CONFLICT 282
FT /note="T -> M (in Ref. 2; BAC27074/BAE30615/BAE36234/
FT BAE41680 and 3; AAH13548)"
FT /evidence="ECO:0000305"
FT CONFLICT 359
FT /note="E -> V (in Ref. 2; BAE31742)"
FT /evidence="ECO:0000305"
FT CONFLICT 405
FT /note="M -> K (in Ref. 2; BAE31742)"
FT /evidence="ECO:0000305"
FT CONFLICT 622
FT /note="T -> I (in Ref. 1; BAD90125, 2; BAC27074/BAE30615/
FT BAE31742/BAE36234/BAE41680 and 3; AAH13548)"
FT /evidence="ECO:0000305"
FT CONFLICT 773
FT /note="R -> K (in Ref. 2; BAC27074)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 802 AA; 84756 MW; 4853B80CAC29B9AE CRC64;
MAATRVQPST REIFTTLEYG PVPESHACAL AWLDTHNRLL GHHVNGMWLK PEHRNPAPCQ
DPITGENLAS CLQAEAEDIA AAVEAAKIAF KAWSQLPGAA RGQHLTRLAK VVQKHQRLLW
TLESLVTGRA VREVRDGDVP LAQQLLQYHA VQAHAQGDAL ADWQPVGVIG LILPTPFSFL
DMMWRVCPAL AMGCTVVALV PPAFPTPLLL AQLAGELGSF PGILNVVCGP ASLGPVLASQ
PGVQKVAFCG AVEEGRVLRR TLAGRGAELG LALGTESLLL LTDSADVDSA VEGVVDAVWS
DRSLGGLRLL IQESVWDEAM RRLQARMAQI RSGRGLDGAV DMGARGAAAR DLAQSFVDEA
QSQGGQVFQA GDVPSSSPFF SPALVSGLPP AAPCAQAEVP WPVVMASPFR TVKEALALAN
GTPRGGSASV WSERLGQALE LGYGLQVGTV WINAHGLRDP AVPTGGCKES GSSWHGGPDG
LYEYLQPLGT PSQESFLCEN INYDTFGLAA SSILPSGPET GPSPAPPYGL FVGGRFQSPG
TQSSRPIQDS SGKVSSYVAE GGAKDIRGAV EAAHQAAPGW GAQSPRARAG LLWALAAALE
RRKPVLTSQL ERHGAAPTVA KTEVELSVRR LQTWGTRVQD QGQTLQVTGL RGPVLRLREP
LGVLAVVCPD EWPLLAFVSL LAPALAHGNA VVLVPSGACP LLALEVCQDI APLFPAGLVS
VVTGDRDHLT RCLALHQDVQ ALWYFGSAQG SQFVEWASAG NLKSVWVNRG FPRAWDVEVQ
GAGQELSLHA ARTKALWLPM GD
