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NAA16_HUMAN
ID   NAA16_HUMAN             Reviewed;         864 AA.
AC   Q6N069; B0QZ59; Q5VSP9; Q6P2D5; Q8N5J3; Q8N870;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 2.
DT   03-AUG-2022, entry version 162.
DE   RecName: Full=N-alpha-acetyltransferase 16, NatA auxiliary subunit;
DE   AltName: Full=NMDA receptor-regulated 1-like protein;
DE            Short=NARG1-like protein;
GN   Name=NAA16; Synonyms=NARG1L, NAT2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA   Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA   Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA   Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA   Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA   Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA   Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA   Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA   Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA   Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA   Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA   Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA   Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA   Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Spleen;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Colon endothelium;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
RC   TISSUE=Colon, and Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   INTERACTION WITH NAA10.
RX   PubMed=19480662; DOI=10.1186/1471-2091-10-15;
RA   Arnesen T., Gromyko D., Kagabo D., Betts M.J., Starheim K.K., Varhaug J.E.,
RA   Anderson D., Lillehaug J.R.;
RT   "A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-
RT   hNaa10p (hNat2-hArd1).";
RL   BMC Biochem. 10:15-15(2009).
RN   [7]
RP   NOMENCLATURE.
RX   PubMed=19660095; DOI=10.1186/1753-6561-3-s6-s2;
RA   Polevoda B., Arnesen T., Sherman F.;
RT   "A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature,
RT   subunits and substrates.";
RL   BMC Proc. 3:S2-S2(2009).
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- FUNCTION: Auxillary subunit of the N-terminal acetyltransferase A
CC       (NatA) complex which displays alpha (N-terminal) acetyltransferase
CC       activity.
CC   -!- SUBUNIT: Component of the N-terminal acetyltransferase A (NatA) complex
CC       composed of NAA10 and NAA16.
CC   -!- INTERACTION:
CC       Q6N069; P41227: NAA10; NbExp=2; IntAct=EBI-2561139, EBI-747693;
CC       Q6N069-4; P14136: GFAP; NbExp=3; IntAct=EBI-10699337, EBI-744302;
CC       Q6N069-4; D3DTS7: PMP22; NbExp=3; IntAct=EBI-10699337, EBI-25882629;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=5;
CC       Name=1;
CC         IsoId=Q6N069-1; Sequence=Displayed;
CC       Name=2; Synonyms=Long;
CC         IsoId=Q6N069-2; Sequence=VSP_012568, VSP_012569;
CC       Name=3;
CC         IsoId=Q6N069-3; Sequence=VSP_012566, VSP_012567;
CC       Name=4; Synonyms=Short;
CC         IsoId=Q6N069-4; Sequence=VSP_012564, VSP_012565;
CC       Name=5;
CC         IsoId=Q6N069-5; Sequence=VSP_012562, VSP_012563;
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DR   EMBL; AL354696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL590665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL731858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK097224; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BX640665; CAE45801.1; -; mRNA.
DR   EMBL; CH471075; EAX08654.1; -; Genomic_DNA.
DR   EMBL; BC032318; AAH32318.1; -; mRNA.
DR   EMBL; BC064592; AAH64592.1; -; mRNA.
DR   CCDS; CCDS45044.1; -. [Q6N069-4]
DR   CCDS; CCDS9379.1; -. [Q6N069-1]
DR   RefSeq; NP_001104268.1; NM_001110798.1. [Q6N069-4]
DR   RefSeq; NP_060997.2; NM_018527.3. [Q6N069-5]
DR   RefSeq; NP_078837.3; NM_024561.4. [Q6N069-1]
DR   RefSeq; XP_011533530.1; XM_011535228.1. [Q6N069-2]
DR   AlphaFoldDB; Q6N069; -.
DR   SMR; Q6N069; -.
DR   BioGRID; 122746; 28.
DR   ComplexPortal; CPX-6272; NatA N-alpha-acetyltransferase complex, NAA10-NAA16 variant.
DR   ComplexPortal; CPX-6274; NatA N-alpha-acetyltransferase complex, NAA11-NAA16 variant.
DR   IntAct; Q6N069; 16.
DR   MINT; Q6N069; -.
DR   STRING; 9606.ENSP00000368716; -.
DR   ChEMBL; CHEMBL3430873; -.
DR   iPTMnet; Q6N069; -.
DR   MetOSite; Q6N069; -.
DR   PhosphoSitePlus; Q6N069; -.
DR   BioMuta; NAA16; -.
DR   DMDM; 57012940; -.
DR   EPD; Q6N069; -.
DR   jPOST; Q6N069; -.
DR   MassIVE; Q6N069; -.
DR   MaxQB; Q6N069; -.
DR   PaxDb; Q6N069; -.
DR   PeptideAtlas; Q6N069; -.
DR   PRIDE; Q6N069; -.
DR   ProteomicsDB; 66613; -. [Q6N069-1]
DR   ProteomicsDB; 66614; -. [Q6N069-2]
DR   ProteomicsDB; 66615; -. [Q6N069-3]
DR   ProteomicsDB; 66616; -. [Q6N069-4]
DR   ProteomicsDB; 66617; -. [Q6N069-5]
DR   Antibodypedia; 23410; 63 antibodies from 18 providers.
DR   DNASU; 79612; -.
DR   Ensembl; ENST00000379406.8; ENSP00000368716.3; ENSG00000172766.19. [Q6N069-1]
DR   Ensembl; ENST00000403412.7; ENSP00000386103.3; ENSG00000172766.19. [Q6N069-4]
DR   Ensembl; ENST00000464857.5; ENSP00000432364.1; ENSG00000172766.19. [Q6N069-3]
DR   GeneID; 79612; -.
DR   KEGG; hsa:79612; -.
DR   MANE-Select; ENST00000379406.8; ENSP00000368716.3; NM_024561.5; NP_078837.3.
DR   UCSC; uc001uye.5; human. [Q6N069-1]
DR   CTD; 79612; -.
DR   DisGeNET; 79612; -.
DR   GeneCards; NAA16; -.
DR   HGNC; HGNC:26164; NAA16.
DR   HPA; ENSG00000172766; Tissue enhanced (bone).
DR   MIM; 619497; gene.
DR   neXtProt; NX_Q6N069; -.
DR   OpenTargets; ENSG00000172766; -.
DR   PharmGKB; PA165505266; -.
DR   VEuPathDB; HostDB:ENSG00000172766; -.
DR   eggNOG; KOG1156; Eukaryota.
DR   GeneTree; ENSGT00950000183174; -.
DR   HOGENOM; CLU_006686_0_0_1; -.
DR   InParanoid; Q6N069; -.
DR   OMA; STCENGE; -.
DR   PhylomeDB; Q6N069; -.
DR   TreeFam; TF106301; -.
DR   PathwayCommons; Q6N069; -.
DR   SignaLink; Q6N069; -.
DR   BioGRID-ORCS; 79612; 24 hits in 1077 CRISPR screens.
DR   ChiTaRS; NAA16; human.
DR   GenomeRNAi; 79612; -.
DR   Pharos; Q6N069; Tbio.
DR   PRO; PR:Q6N069; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   RNAct; Q6N069; protein.
DR   Bgee; ENSG00000172766; Expressed in body of pancreas and 201 other tissues.
DR   ExpressionAtlas; Q6N069; baseline and differential.
DR   Genevisible; Q6N069; HS.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0031415; C:NatA complex; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005667; C:transcription regulator complex; ISS:UniProtKB.
DR   GO; GO:0043022; F:ribosome binding; IDA:UniProtKB.
DR   GO; GO:0017196; P:N-terminal peptidyl-methionine acetylation; IBA:GO_Central.
DR   GO; GO:0006474; P:N-terminal protein amino acid acetylation; IDA:UniProtKB.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0050821; P:protein stabilization; IMP:UniProtKB.
DR   InterPro; IPR021183; NatA_aux_su.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR013105; TPR_2.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF12569; NARP1; 1.
DR   Pfam; PF07719; TPR_2; 1.
DR   PIRSF; PIRSF000422; N-terminal-AcTrfase-A_aux_su; 1.
DR   SMART; SM00028; TPR; 6.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 5.
DR   PROSITE; PS50293; TPR_REGION; 3.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..864
FT                   /note="N-alpha-acetyltransferase 16, NatA auxiliary
FT                   subunit"
FT                   /id="PRO_0000106297"
FT   REPEAT          46..79
FT                   /note="TPR 1"
FT   REPEAT          80..113
FT                   /note="TPR 2"
FT   REPEAT          148..184
FT                   /note="TPR 3"
FT   REPEAT          224..257
FT                   /note="TPR 4"
FT   REPEAT          374..407
FT                   /note="TPR 5"
FT   REPEAT          409..441
FT                   /note="TPR 6"
FT   REPEAT          485..518
FT                   /note="TPR 7"
FT   REGION          603..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         304..311
FT                   /note="ERFRELMD -> FYNPGTCY (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_012562"
FT   VAR_SEQ         312..864
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_012563"
FT   VAR_SEQ         420..429
FT                   /note="HIGNLKEAAK -> VKSESCFLSS (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_012564"
FT   VAR_SEQ         430..864
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_012565"
FT   VAR_SEQ         514..516
FT                   /note="HFF -> VSC (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_012566"
FT   VAR_SEQ         515..530
FT                   /note="FFEITDDQFDFHTYCM -> SPSTWTTGGKEPQMHP (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:17974005"
FT                   /id="VSP_012568"
FT   VAR_SEQ         517..864
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_012567"
FT   VAR_SEQ         531..864
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:17974005"
FT                   /id="VSP_012569"
FT   VARIANT         344
FT                   /note="E -> G (in dbSNP:rs17062054)"
FT                   /id="VAR_052618"
SQ   SEQUENCE   864 AA;  101462 MW;  510001EC0D9DD592 CRC64;
     MPNVLLPPKE SNLFKRILKC YEQKQYKNGL KFCKMILSNP KFAEHGETLA MKGLTLNCLG
     KKEEAYEFVR KGLRNDVKSH VCWHVYGLLQ RSDKKYDEAI KCYRNALKLD KDNLQILRDL
     SLLQIQMRDL EGYRETRYQL LQLRPTQRAS WIGYAIAYHL LKDYDMALKL LEEFRQTQQV
     PPNKIDYEYS ELILYQNQVM READLLQESL EHIEMYEKQI CDKLLVEEIK GEILLKLGRL
     KEASEVFKNL IDRNAENWCY YEGLEKALQI STLEERLQIY EEISKQHPKA ITPRRLPLTL
     VPGERFRELM DKFLRVNFSK GCPPLFTTLK SLYYNTEKVS IIQELVTNYE ASLKTCDFFS
     PYENGEKEPP TTLLWVQYFL AQHFDKLGQY SLALDYINAA IASTPTLIEL FYMKAKIYKH
     IGNLKEAAKW MDEAQSLDTA DRFINSKCAK YMLRANMIKE AEEMCSKFTR EGTSAMENLN
     EMQCMWFQTE CISAYQRLGR YGDALKKCHE VERHFFEITD DQFDFHTYCM RKMTLRAYVD
     LLRLEDILRR HAFYFKAARS AIEIYLKLYD NPLTNESKQQ EINSENLSAK ELKKMLSKQR
     RAQKKAKLEE ERKHAERERQ QKNQKKKRDE EEEEASGLKE ELIPEKLERV ENPLEEAVKF
     LIPLKNLVAD NIDTHLLAFE IYFRKGKFLL MLQSVKRAFA INSNNPWLHE CLIRFSKSVS
     NHSNLPDIVS KVLSQEMQKI FVKKDLESFN EDFLKRNATS LQHLLSGAKM MYFLDKSRQE
     KAIAIATRLD ETIKDKDVKT LIKVSEALLD GSFGNCSSQY EEYRMACHNL LPFTSAFLPA
     VNEVDNPNVA LNHTANYDVL ANEI
 
 
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