NAA16_MOUSE
ID NAA16_MOUSE Reviewed; 864 AA.
AC Q9DBB4; Q3U7V2;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=N-alpha-acetyltransferase 16, NatA auxiliary subunit;
DE AltName: Full=NMDA receptor-regulated 1-like protein;
DE Short=NARG1-like protein;
GN Name=Naa16; Synonyms=Narg1l, Nat2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=12888564; DOI=10.1074/jbc.m301218200;
RA Sugiura N., Adams S.M., Corriveau R.A.;
RT "An evolutionarily conserved N-terminal acetyltransferase complex
RT associated with neuronal development.";
RL J. Biol. Chem. 278:40113-40120(2003).
CC -!- FUNCTION: Auxillary subunit of the N-terminal acetyltransferase A
CC (NatA) complex which displays alpha (N-terminal) acetyltransferase
CC activity. {ECO:0000250}.
CC -!- SUBUNIT: Component of the N-terminal acetyltransferase A (NatA) complex
CC composed of NAA10 and NAA16. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highest levels in the kidney and testes. Moderate
CC expression in the liver, thymus and skin.
CC {ECO:0000269|PubMed:12888564}.
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DR EMBL; AK005056; BAB23782.1; -; mRNA.
DR EMBL; AK152498; BAE31267.1; -; mRNA.
DR EMBL; BC052445; AAH52445.1; -; mRNA.
DR CCDS; CCDS27296.1; -.
DR RefSeq; NP_080108.1; NM_025832.2.
DR AlphaFoldDB; Q9DBB4; -.
DR SMR; Q9DBB4; -.
DR STRING; 10090.ENSMUSP00000022597; -.
DR iPTMnet; Q9DBB4; -.
DR PhosphoSitePlus; Q9DBB4; -.
DR EPD; Q9DBB4; -.
DR MaxQB; Q9DBB4; -.
DR PaxDb; Q9DBB4; -.
DR PeptideAtlas; Q9DBB4; -.
DR PRIDE; Q9DBB4; -.
DR ProteomicsDB; 287662; -.
DR Antibodypedia; 23410; 63 antibodies from 18 providers.
DR DNASU; 66897; -.
DR Ensembl; ENSMUST00000022597; ENSMUSP00000022597; ENSMUSG00000022020.
DR GeneID; 66897; -.
DR KEGG; mmu:66897; -.
DR UCSC; uc007usv.1; mouse.
DR CTD; 79612; -.
DR MGI; MGI:1914147; Naa16.
DR VEuPathDB; HostDB:ENSMUSG00000022020; -.
DR eggNOG; KOG1156; Eukaryota.
DR GeneTree; ENSGT00950000183174; -.
DR HOGENOM; CLU_006686_0_0_1; -.
DR InParanoid; Q9DBB4; -.
DR OMA; STCENGE; -.
DR OrthoDB; 792708at2759; -.
DR PhylomeDB; Q9DBB4; -.
DR TreeFam; TF106301; -.
DR BioGRID-ORCS; 66897; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Naa16; mouse.
DR PRO; PR:Q9DBB4; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q9DBB4; protein.
DR Bgee; ENSMUSG00000022020; Expressed in animal zygote and 219 other tissues.
DR ExpressionAtlas; Q9DBB4; baseline and differential.
DR Genevisible; Q9DBB4; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0031415; C:NatA complex; ISO:MGI.
DR GO; GO:0043022; F:ribosome binding; ISO:MGI.
DR GO; GO:0017196; P:N-terminal peptidyl-methionine acetylation; IBA:GO_Central.
DR GO; GO:0006474; P:N-terminal protein amino acid acetylation; ISO:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
DR GO; GO:0050821; P:protein stabilization; ISO:MGI.
DR InterPro; IPR021183; NatA_aux_su.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR013105; TPR_2.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF12569; NARP1; 1.
DR Pfam; PF07719; TPR_2; 1.
DR PIRSF; PIRSF000422; N-terminal-AcTrfase-A_aux_su; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 5.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..864
FT /note="N-alpha-acetyltransferase 16, NatA auxiliary
FT subunit"
FT /id="PRO_0000106298"
FT REPEAT 46..79
FT /note="TPR 1"
FT REPEAT 80..113
FT /note="TPR 2"
FT REPEAT 148..184
FT /note="TPR 3"
FT REPEAT 224..257
FT /note="TPR 4"
FT REPEAT 374..407
FT /note="TPR 5"
FT REPEAT 408..441
FT /note="TPR 6"
FT REPEAT 485..514
FT /note="TPR 7"
FT REGION 594..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 101284 MW; 1E55504ACCE88129 CRC64;
MPCVQLPAKE SALFKRVLKC YEQKQYKNGL KFCKMILSNP KFAEHGETLA MKGLILNCLG
KREEAYEFVR KGLRSDVRSH VCWHVYGLLQ RSDKKYDEAI KCYRNALKLD KDNLQILRDL
SLLQIQMRDL EGYRETRYQL LQLRPTQRAS WIGYAIAYHL LKDYDTALKL LEEFRQTQQV
PPNKIAYEYS ELLLYQNQVM REANLFQESL EHIETYEKLI CDKLLVEEIK GEMLLKLGRL
KEASEVFRNL IDWNAENWCY YEGLEKALQL RSLDERLQLY EEVSKQHPRA VSPRRLPLSF
APGKKFRELM DKFLRPNFSK GCPPLFTTLK SLYCDTEKVS IIQELVTNYE ASLKMNGYFS
PYENGEKEPP TTLIWVQYFL AQHYDKLGQY FLALEYINAV IASTPTLIEL FYMKAKIYKH
MGNLKEAAQW MDEAQSLDTA DRFINSKCAK YMLRANMIKE AEEMCSRFTR EGTSAMENLN
EMQCMWFETE CISAYQRLGR YGDALKKCHE VERHFLEITD DQFDFHTYCM RKMTLRAYVG
LLRLEDALRR HTFYFKAARS AIEIYLKLHD NPLTNDSKQQ DIDSENLSAK EMKKMLSKQR
RAQKKAKVEE ERKHTERERQ QKNQKKKREE EEEVTSGHKE ELIPEKLERV DNPLEEAIKF
LTPLKTLAAE SIDTHLLAFE IYFRKGKFLL MLQSVKRAFA IESNNPWLHE CLIKFSKSVS
NHSNLPDIVS KVLAQEMKKI FVNKDLHSFN EDFLRHNATS LQHLLAGAKM MYFLDKSRQE
KAIATATRLD ETIKNKNVKT LIKVSEALLD GSFGNCSSQY EEYRKTCHSL LPLTPAFLPA
AREALGLSAE LNHTADHKLL MNEI
