ID   NAA25_AEDAE             Reviewed;         940 AA.
AC   Q17DK2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Phagocyte signaling-impaired protein;
DE   AltName: Full=N-terminal acetyltransferase B complex subunit MDM20 homolog;
DE   AltName: Full=N-terminal acetyltransferase B complex subunit NAA25 homolog;
GN   Name=psidin {ECO:0000250|UniProtKB:Q9VDQ7}; ORFNames=AAEL004142;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000312|EMBL:EAT44499.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Non-catalytic subunit of the NatB complex which catalyzes
CC       acetylation of the N-terminal methionine residues of proteins beginning
CC       with Met-Asp or Met-Glu (By similarity). Has 2 roles in the larval
CC       immune response: required both for the phagocytic degradation of
CC       internalized bacteria and for the induction of Defensin in the fat
CC       body. Within the phagocytic blood cells, has a role in detection of
CC       infection and activation of the humoral immune response (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the N-terminal acetyltransferase B (NatB)
CC       complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q9VDQ7}.
CC       Note=Blood cell lysosomes. {ECO:0000250|UniProtKB:Q9VDQ7}.
CC   -!- SIMILARITY: Belongs to the MDM20/NAA25 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAT44499.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH477293; EAT44499.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001648501.1; XM_001648451.1.
DR   AlphaFoldDB; Q17DK2; -.
DR   SMR; Q17DK2; -.
DR   STRING; 7159.AAEL004142-PA; -.
DR   PRIDE; Q17DK2; -.
DR   VEuPathDB; VectorBase:AAEL004142; -.
DR   eggNOG; KOG2053; Eukaryota.
DR   InParanoid; Q17DK2; -.
DR   OrthoDB; 1022953at2759; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0006955; P:immune response; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0006911; P:phagocytosis, engulfment; ISS:UniProtKB.
DR   InterPro; IPR019183; N-acetylTrfase_B_cplx_non-cat.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR22767:SF3; PTHR22767:SF3; 1.
DR   Pfam; PF09797; NatB_MDM20; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Antimicrobial; Immunity; Innate immunity; Lysosome; Reference proteome;
KW   TPR repeat.
FT   CHAIN           1..940
FT                   /note="Phagocyte signaling-impaired protein"
FT                   /id="PRO_0000314623"
FT   REPEAT          77..110
FT                   /note="TPR"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   940 AA;  108037 MW;  1DD8CC04D887B504 CRC64;
     MQQLQLHDVW EKLRPRDESI ELGHYKKALQ DVEKVLKKNP TIQCGRALKA WAFLRLGRDE
     ESAALIKALE QETPTESTTL HVMTLCYKET DQLDKICQIF TSASKQLPGN EELLSQLFIA
     HMRVNDFKAQ QTVAMQLYKL KPRNPFYFWA VTSVMLQALR GPDAKDQQKS SLLLSLAQRM
     VDKLIADNKI EASQEVQLYL QILQHQEKYQ EMLTFLDGPV CTNLYPGAPH SIKIDLLKKL
     NKWADLNKLM KQLLTEDPDR WDYYQDYILS TIEMIKCKDE TPETDHTVDM CHEFIAGIIE
     SQPRKNRGPY LARLELARLM VKHKFDKEQQ FGELTELLLD YFRMFGDKTC CANDLKLFLE
     YVEPAKRPGF AAQLMQECRI NPVTLPSSKE HMQRHICSLQ IARFCGAHAA LSEEHLSALY
     TALSLHYEHG YNTFGQGLLP TDMGPSDPYA LLAVNIMYDR AWKLQRSEPL VEALCLLNHL
     LSNSINNFHG KLLNLQLYHR LGLVEAAHRA YESLDIKHIQ LDSLGYLHCS HLCNGGFPAL
     AKQIFDQTLH FFINDTNSVE FLKTSYNFGS FSKLIEFLDF RDRLSNSLHF TLISVEALLL
     EMVCFSGTLA QNLAAYRLMR IKPQEDRIKW DEMSDNRDLT IFVHWDPTVE QLREECQKDS
     FSQEHELLQL RSGLLRLVSS FIELFTKGGD DEYQTAQDLS RHWEELFVTV RAKNRQPACE
     RFLVNLLPSR LHSVLAMPYE AVFRDLASFL LALWKGEKHD QIRSGAERCV KHVNDLFELI
     AGSIKTYNSS GDLLWNRKKV HDTVNACVEI AALVLFVMTV CFDKYSQAPA PQPTRKTKKK
     DSEQNNHEPA VVLMTEKNRL QLVVDVLRAL KTNLVDCEAV LSSWELPLLS DSLAGALEQM
     SLGAKSESAV RLKLMDTHLG EIKELKKLLK DKLKLINKSI