ID   NAA25_ANOGA             Reviewed;         990 AA.
AC   Q7PYI4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2012, sequence version 5.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Phagocyte signaling-impaired protein;
DE   AltName: Full=N-terminal acetyltransferase B complex subunit MDM20 homolog;
DE   AltName: Full=N-terminal acetyltransferase B complex subunit NAA25 homolog;
GN   Name=psidin {ECO:0000250|UniProtKB:Q9VDQ7}; ORFNames=AGAP001954;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Non-catalytic subunit of the NatB complex which catalyzes
CC       acetylation of the N-terminal methionine residues of proteins beginning
CC       with Met-Asp or Met-Glu (By similarity). Has 2 roles in the larval
CC       immune response: required both for the phagocytic degradation of
CC       internalized bacteria and for the induction of Defensin in the fat
CC       body. Within the phagocytic blood cells, has a role in detection of
CC       infection and activation of the humoral immune response (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the N-terminal acetyltransferase B (NatB)
CC       complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q9VDQ7}.
CC       Note=Blood cell lysosomes. {ECO:0000250|UniProtKB:Q9VDQ7}.
CC   -!- SIMILARITY: Belongs to the MDM20/NAA25 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAAB01008987; EAA01102.5; -; Genomic_DNA.
DR   RefSeq; XP_321109.5; XM_321109.5.
DR   AlphaFoldDB; Q7PYI4; -.
DR   SMR; Q7PYI4; -.
DR   STRING; 7165.AGAP001954-PA; -.
DR   PaxDb; Q7PYI4; -.
DR   GeneID; 1281170; -.
DR   KEGG; aga:AgaP_AGAP001954; -.
DR   CTD; 1281170; -.
DR   VEuPathDB; VectorBase:AGAP001954; -.
DR   eggNOG; KOG2053; Eukaryota.
DR   HOGENOM; CLU_008075_0_0_1; -.
DR   InParanoid; Q7PYI4; -.
DR   OMA; CMASSIL; -.
DR   OrthoDB; 1022953at2759; -.
DR   PhylomeDB; Q7PYI4; -.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0031416; C:NatB complex; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0017196; P:N-terminal peptidyl-methionine acetylation; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; ISS:UniProtKB.
DR   InterPro; IPR019183; N-acetylTrfase_B_cplx_non-cat.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR22767:SF3; PTHR22767:SF3; 1.
DR   Pfam; PF09797; NatB_MDM20; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Antimicrobial; Coiled coil; Immunity; Innate immunity; Lysosome;
KW   Reference proteome; TPR repeat.
FT   CHAIN           1..990
FT                   /note="Phagocyte signaling-impaired protein"
FT                   /id="PRO_0000314624"
FT   REPEAT          76..109
FT                   /note="TPR"
FT                   /evidence="ECO:0000255"
FT   REGION          645..672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          871..902
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          964..986
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        652..667
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        885..902
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   990 AA;  112923 MW;  AC8000EF10094874 CRC64;
     MQQEDLAYER KLRPIWESIE IGNYKKALQD VEKMLKKKPT LQCARALKAW AYQRLGRTED
     SAPLIAALEE EQPIEATTLH ALTLYYKETQ RLDKICTLFS NAVRQVPGSE ELLSQLFIAY
     MRIDDFKALQ SVALQLYKLR PRNSYYFWAV MSVVLQALRG PDAHNAQKAQ LLLVLAQRMV
     DKFIAENKLE GAQEAQLYLQ ILQEQHKYSE AYDFLQGALC QKLYPGAPVY LRIDLLKQLN
     KWGELNRLLK ELLLQEQDRW DYYQDYINST FELIRAGEKP DGADYTVEMC HEFLCDIIEA
     QPKKFRGPYL ARLELNRRMV EQRYAAEQLF GKMSDMLAEY FELFADKPCC ALDMKLFLEF
     VKPAHERRTL ATKLMNGLGL SSATLPASKE QMQRHICTLQ IARYSGAHAI VSEELLHAIY
     TSLSLHYEHG YNAYGQGLLV TDMGPSDAYA LLAAQIMYER AYRMQRSEPA IEALCLLNHL
     LGNSVNNFHG KLLALQLYHR LGLTQAAQSA YETLDIKHIQ LDSLGYLHCA QLANAGFPAL
     AKATYEQTLY FFLNDIDANS EFPKALYNFG TFSKLVEIVD FRSRLANSYH FMLVTVETLL
     LMVVSSGGTL SQLLAAYRQT RRKPAEDRIR WDKLHDNRDL TIFVSWDPPS DEEEQEEKKD
     KPMDNGTGGE KEAPVVAAVT KPVGATLEER RERLQKRSYE QDYDLLRLRT GLSKMLFSLV
     ELHLSRTSVE CSAAQQLRDD WVTVAADIRS KQHAPISGRY LVNLLPSRLH LYLSLPYERV
     FTQLADFVLD LWKGYSIEQL TLAADKCSGD VTAIHETMKR AIETYHQSAD LLWHWKMTHE
     LVNGCIEMIS LMVFLLAVCY DKYLHAPTSQ AQPSAGKKVK KGPENSAPNT ATTTNASNDA
     SSVVPERERL VLVTKVLREL KQTINAMDLL LASWKPPLVE DSLSAAIERM SLNPKCASTV
     QSTIAENALT EVRDLRKLLK DKLKLMSKAI