NAA25_ARATH
ID NAA25_ARATH Reviewed; 1065 AA.
AC F4KEY9; Q84WG5; Q9FGH7;
DT 15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=N-terminal acetyltransferase B complex auxiliary subunit NAA25 {ECO:0000303|PubMed:25966763};
DE AltName: Full=N-terminal acetyltransferase B complex auxiliary subunit TCU2 {ECO:0000303|PubMed:24244708};
DE AltName: Full=NatB N-alpha-terminal acetylation complex non-catalytic subunit {ECO:0000303|PubMed:24244708};
DE AltName: Full=Protein TRANSCURVATA 2 {ECO:0000303|PubMed:24244708};
GN Name=NAA25 {ECO:0000303|PubMed:25966763};
GN Synonyms=TCU2 {ECO:0000303|PubMed:24244708};
GN OrderedLocusNames=At5g58450 {ECO:0000312|Araport:AT5G58450};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 23-1065.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=24244708; DOI=10.1371/journal.pone.0080697;
RA Ferrandez-Ayela A., Micol-Ponce R., Sanchez-Garcia A.B., Alonso-Peral M.M.,
RA Micol J.L., Ponce M.R.;
RT "Mutation of an Arabidopsis NatB N-alpha-terminal acetylation complex
RT component causes pleiotropic developmental defects.";
RL PLoS ONE 8:E80697-E80697(2013).
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=25966763; DOI=10.1105/tpc.15.00173;
RA Xu F., Huang Y., Li L., Gannon P., Linster E., Huber M., Kapos P.,
RA Bienvenut W., Polevoda B., Meinnel T., Hell R., Giglione C., Zhang Y.,
RA Wirtz M., Chen S., Li X.;
RT "Two N-terminal acetyltransferases antagonistically regulate the stability
RT of a nod-like receptor in Arabidopsis.";
RL Plant Cell 27:1547-1562(2015).
CC -!- FUNCTION: Auxiliary subunit of the NatB N-alpha-acetyltransferase
CC complex. Required for flowering time regulation and for vegetative and
CC reproductive plant development. {ECO:0000269|PubMed:24244708}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24244708}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed, with a higher expression in
CC vascular bundles, hydathodes, leaf primordia and the base of the
CC trichomes. {ECO:0000269|PubMed:24244708}.
CC -!- DISRUPTION PHENOTYPE: Leaf reticulation, mild leaf folding, early
CC flowering and aborted or unfertilized ovules in siliques
CC (PubMed:24244708). No stunted growth or enhanced resistance to
CC pathogens (PubMed:25966763). {ECO:0000269|PubMed:24244708,
CC ECO:0000269|PubMed:25966763}.
CC -!- SIMILARITY: Belongs to the MDM20/NAA25 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB10260.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB025632; BAB10260.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED97054.1; -; Genomic_DNA.
DR EMBL; BT003846; AAO41896.1; -; mRNA.
DR RefSeq; NP_200653.2; NM_125231.4.
DR AlphaFoldDB; F4KEY9; -.
DR SMR; F4KEY9; -.
DR STRING; 3702.AT5G58450.1; -.
DR PaxDb; F4KEY9; -.
DR PRIDE; F4KEY9; -.
DR ProteomicsDB; 251012; -.
DR EnsemblPlants; AT5G58450.1; AT5G58450.1; AT5G58450.
DR GeneID; 835958; -.
DR Gramene; AT5G58450.1; AT5G58450.1; AT5G58450.
DR KEGG; ath:AT5G58450; -.
DR Araport; AT5G58450; -.
DR TAIR; locus:2171228; AT5G58450.
DR eggNOG; KOG2053; Eukaryota.
DR HOGENOM; CLU_012690_0_0_1; -.
DR InParanoid; F4KEY9; -.
DR OrthoDB; 1022953at2759; -.
DR PRO; PR:F4KEY9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4KEY9; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031416; C:NatB complex; IBA:GO_Central.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0017196; P:N-terminal peptidyl-methionine acetylation; IBA:GO_Central.
DR InterPro; IPR019183; N-acetylTrfase_B_cplx_non-cat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR22767:SF3; PTHR22767:SF3; 1.
DR Pfam; PF09797; NatB_MDM20; 1.
DR SMART; SM00028; TPR; 2.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; TPR repeat.
FT CHAIN 1..1065
FT /note="N-terminal acetyltransferase B complex auxiliary
FT subunit NAA25"
FT /id="PRO_0000439080"
FT REPEAT 294..327
FT /note="TPR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 1065 AA; 121463 MW; A3647BDB3DA887A0 CRC64;
MRRWGLWEQE TNVHTVAESD NFQSFPDRVE ILCLTGTESF DVKGQQLIKT LQKGFPTKFL
SSQMSSKFGL AGGIPERRVR PIWDAIDSRQ FKNALKLVTS LLAKYPKSPY ALALKALIHE
RMGKTDEALS VCLDAKELLY KDDLALMDDL TLSTLQIVLQ RLDHLDLATS CYAHACGKYP
NNLELMMGLF NCYVREYSFV KQQQTAIKMY KLAGEERFLL WAVCSIQLQV LCDKSGEKLL
LLAEGLLKKH IASHSMHEPE ALMVYISLLE QQSKYNDALE VLSGDLGSLL MIEVDKLRIQ
GRLLARANDY SAAVDVYKKI LELSPDDWEC FLHYLGCLLE DDSIWKYFDN IDQIHPTKHI
ECKFSHLTEE MFDSRISSAS DLVQKLQRDA ENSNLRGPYL AELEIEKRKF LFGKKNEDKL
LESLLQYFLK FGHLACYASD VEAYLQVLSP NKKAGFVEML VKNSDSSASA TKVLGQTTTI
LKVQELTGNI FGLPTDEIEA SAVKLAKLYC QNLSLSKDLD PQESMFGEEL LSLISNMLVQ
LFWRTRDFGY LAEAIMVLEL GLTIRGHVWQ YKILLLHIYS YVGALPLAFE RYKALDVKNI
LTETVSHHIL RQMLESPMWV DLSNLLKDYL KFMDDHLRES ADLTFLAYRH RNYSKVIEFV
LFKQRLQHSN QYQAARVEAS VLQLKQNADS FEEEERILEN LKSGVQLVEL SNEIGSRTLK
FNEDMQTRPW WTPCPEKNYL LGPFEEISYC PPKENVKEER EENMKRAIQR KSLLPRMIYL
SIQCTPTALK ESVETNGSGG DIDVCEELKC LLEDYTKMLG CSLSDAVEMI TEISQGARTS
ESLGSNLVDW LNFAVFWNAW SLSSQEHWHV LNSLFERLIL DRVRSMGSSD MSSCYSDVQV
LVQIITEPLA WHSLIIQACT RSSLPSGKKK KKNQHSDQLS SSPISQAIKD SIQLLCSTIQ
DVSNWLLNQL NNPEDGQVEG FLTTLKRDGN AAGPGQILGV LESFIASSEE SEVGNRIFQA
LKSWNTADTA RKTVMAQQRV LREFLQICES KRKLLETLKQ QMSHV
