ID   NAA25_DROPS             Reviewed;         962 AA.
AC   Q294E0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 3.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Phagocyte signaling-impaired protein;
DE   AltName: Full=N-terminal acetyltransferase B complex subunit MDM20 homolog;
DE   AltName: Full=N-terminal acetyltransferase B complex subunit NAA25 homolog;
GN   Name=psidin {ECO:0000250|UniProtKB:Q9VDQ7}; ORFNames=GA18473;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Non-catalytic subunit of the NatB complex which catalyzes
CC       acetylation of the N-terminal methionine residues of proteins beginning
CC       with Met-Asp or Met-Glu (By similarity). Has 2 roles in the larval
CC       immune response: required both for the phagocytic degradation of
CC       internalized bacteria and for the induction of Defensin in the fat
CC       body. Within the phagocytic blood cells, has a role in detection of
CC       infection and activation of the humoral immune response (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the N-terminal acetyltransferase B (NatB)
CC       complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q9VDQ7}.
CC       Note=Blood cell lysosomes. {ECO:0000250|UniProtKB:Q9VDQ7}.
CC   -!- SIMILARITY: Belongs to the MDM20/NAA25 family. {ECO:0000305}.
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DR   EMBL; CM000070; EAL29024.2; -; Genomic_DNA.
DR   RefSeq; XP_001359872.2; XM_001359835.3.
DR   AlphaFoldDB; Q294E0; -.
DR   SMR; Q294E0; -.
DR   STRING; 7237.FBpp0281118; -.
DR   EnsemblMetazoa; FBtr0282680; FBpp0281118; FBgn0078475.
DR   GeneID; 4803072; -.
DR   KEGG; dpo:Dpse_GA18473; -.
DR   eggNOG; KOG2053; Eukaryota.
DR   HOGENOM; CLU_008075_0_0_1; -.
DR   InParanoid; Q294E0; -.
DR   OMA; ICRRMWA; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0078475; Expressed in adult organism and 3 other tissues.
DR   GO; GO:1990761; C:growth cone lamellipodium; IEA:EnsemblMetazoa.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0031416; C:NatB complex; IEA:EnsemblMetazoa.
DR   GO; GO:0051015; F:actin filament binding; IEA:EnsemblMetazoa.
DR   GO; GO:0030042; P:actin filament depolymerization; IEA:EnsemblMetazoa.
DR   GO; GO:0002253; P:activation of immune response; IEA:EnsemblMetazoa.
DR   GO; GO:0007298; P:border follicle cell migration; IEA:EnsemblMetazoa.
DR   GO; GO:0006955; P:immune response; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:EnsemblMetazoa.
DR   GO; GO:0006911; P:phagocytosis, engulfment; ISS:UniProtKB.
DR   GO; GO:0010592; P:positive regulation of lamellipodium assembly; IEA:EnsemblMetazoa.
DR   GO; GO:0097374; P:sensory neuron axon guidance; IEA:EnsemblMetazoa.
DR   InterPro; IPR019183; N-acetylTrfase_B_cplx_non-cat.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR22767:SF3; PTHR22767:SF3; 1.
DR   Pfam; PF09797; NatB_MDM20; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Antimicrobial; Immunity; Innate immunity; Lysosome; Reference proteome;
KW   Repeat; TPR repeat.
FT   CHAIN           1..962
FT                   /note="Phagocyte signaling-impaired protein"
FT                   /id="PRO_0000314626"
FT   REPEAT          45..78
FT                   /note="TPR 1"
FT   REPEAT          79..112
FT                   /note="TPR 2"
FT   REPEAT          523..560
FT                   /note="TPR 3"
FT   REGION          856..880
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   962 AA;  110950 MW;  7B0DAAF2B8107949 CRC64;
     MAHQGMDTAL FERRLRPIYD NLEVGNNRKA LQESEKLLRK HPSMLCARAL KGLALLRLGR
     YEESHGCLQA VAEDKPTDDS TLQVLSFCYR EMEQLNKIVE LYQHAVKKNP GNEELLAHLF
     ISYVRVEDYK AQQAVALQLY KAQPKNAYYF WSVISVVFQG IRGPESAVPE KRKIYLGLAQ
     RMVEKHIREG KLESEQEAFL YLHILKLQKK FQEAWEFLTG ELCAKLYPGA PVSMKFELLK
     VLGNWRELNE LLQQLLDADR DRWDYYKEYI QSCFEILKLP ITEGATEEKK FSLSACQEFL
     QGIIDSSERK KRGPYLARLE LHQRMRAHQL PADQLIGDFD ELVVEYFSLF ADKSCCTHDI
     ALFLPSVSMK QRQALANKLL LESGVSSTSL PMNKEQMQKH ICALQISRMC GAHIDLPIDH
     LLAFYTALKL HYEHGRSTFG NKLLSTEMGP SDPYALLAAN VMYDISLREN KSDYLFEALC
     LLQYVLRNST SNFHVKLLSL KIYHMFGCLL GAQEMYEYLD IKQIQLDSMG YVHCQLLPLC
     GRFSGARNSY DTTMKFFTNS YKERLEYIAL TYRFCTFSKM EEFLNFKERL TNSLQYVTCS
     LEAQICDLVS CYANVHQNLS TYTVMSIEPA EDRIAWHELS DNRDLDAIIR WDPLHQVDAD
     AERKDSFDQE IEVLQLRSLM LRLYATFIDL YHPPPITKPS LSDGSKEETP APAVESATST
     LELLRDSWTG LYQRLRLMNY KPLPQQFLVN LLPTRLHLLL ELPYERFFDD LAQLVLDLHS
     GAASLAAHCK KVGDNVIAVM ELCVRTIEES NEWNNKDGLW KRRYQQQKVA ASLEMLSLYA
     FLLSVLNDKL QVSSKTKVKK KQGDNKTQDT PQPVSEKERS QMVQELMRQL KHKLEACDAA
     IRTWKAPVLP RDLSSFMADM SLKPEVEATL IGDVSATFKD SHELMVTELR NLLKDKIRMV
     AK