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NAA25_RAT
ID   NAA25_RAT               Reviewed;         970 AA.
AC   Q6QI44;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=N-alpha-acetyltransferase 25, NatB auxiliary subunit;
DE   AltName: Full=Liver regeneration-related protein LRRGT00164;
DE   AltName: Full=Mitochondrial distribution and morphology protein 20;
DE   AltName: Full=N-terminal acetyltransferase B complex subunit MDM20;
DE            Short=NatB complex subunit MDM20;
DE   AltName: Full=N-terminal acetyltransferase B complex subunit NAA25;
GN   Name=Naa25; Synonyms=Mdm20;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Xu C.S., Zhang L., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y.,
RA   Yang K.J., Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M.,
RA   Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non-catalytic subunit of the NatB complex which catalyzes
CC       acetylation of the N-terminal methionine residues of peptides beginning
CC       with Met-Asp-Glu. May play a role in normal cell-cycle progression.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the N-terminal acetyltransferase B (NatB) complex
CC       which is composed of NAA20 and NAA25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MDM20/NAA25 family. {ECO:0000305}.
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DR   EMBL; AY539915; AAS66255.1; -; mRNA.
DR   RefSeq; NP_001041365.1; NM_001047900.1.
DR   AlphaFoldDB; Q6QI44; -.
DR   SMR; Q6QI44; -.
DR   STRING; 10116.ENSRNOP00000049175; -.
DR   PhosphoSitePlus; Q6QI44; -.
DR   jPOST; Q6QI44; -.
DR   PaxDb; Q6QI44; -.
DR   PRIDE; Q6QI44; -.
DR   Ensembl; ENSRNOT00000048984; ENSRNOP00000049175; ENSRNOG00000001350.
DR   GeneID; 360811; -.
DR   KEGG; rno:360811; -.
DR   CTD; 80018; -.
DR   RGD; 1305685; Naa25.
DR   eggNOG; KOG2053; Eukaryota.
DR   GeneTree; ENSGT00950000183174; -.
DR   InParanoid; Q6QI44; -.
DR   PhylomeDB; Q6QI44; -.
DR   PRO; PR:Q6QI44; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000001350; Expressed in skeletal muscle tissue and 20 other tissues.
DR   ExpressionAtlas; Q6QI44; baseline and differential.
DR   Genevisible; Q6QI44; RN.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0031416; C:NatB complex; IBA:GO_Central.
DR   GO; GO:0017196; P:N-terminal peptidyl-methionine acetylation; IBA:GO_Central.
DR   InterPro; IPR019183; N-acetylTrfase_B_cplx_non-cat.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR22767:SF3; PTHR22767:SF3; 1.
DR   Pfam; PF09797; NatB_MDM20; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..970
FT                   /note="N-alpha-acetyltransferase 25, NatB auxiliary
FT                   subunit"
FT                   /id="PRO_0000294339"
FT   REPEAT          11..44
FT                   /note="TPR 1"
FT   REPEAT          45..78
FT                   /note="TPR 2"
FT   REPEAT          79..112
FT                   /note="TPR 3"
FT   REPEAT          114..146
FT                   /note="TPR 4"
SQ   SEQUENCE   970 AA;  111258 MW;  E55DA4DFBD2B88B4 CRC64;
     MATRGHVQDP NDRRLRPIYD YLDNGNNKMA IQQADKLLKK HRDLHCAKVL KAIGLQRTGR
     QEEAFTLAQE VAALEPTDDN SLQALTILYR EMHRPELVTK LYEAAVKKVP NSEEYHSHLF
     MAYARVGEYK KMQQAGMALY KIVPKNPYYF WSVMSLIMQS ISARDENLSK TMFLPLAERM
     VEKMVKEDKI EAEAEVELYY MILERLGKYQ EALDVIRGKL GEKLTSEIQS RENKCMAMYK
     KLSKWPECNA LSRRLLLKNS DDWQFYLTYF DSVFRLIEEA WTPPAEGEHS LEGEVHCSAE
     DAVKFIEDRI TEASQSSRHV RGPHLAKLEL IRRLRSQGCN DEFRLGDPEE LMFQYFKKFG
     DKPCCFTDLK VFVDLLPAAQ CTQFINQLLG VVPLSTPTED KLALPADIRG LQQHLCVVQL
     TRLLGLYHSM DKNQKLDVVR ELMLRYQHGL EFGRSCLKTE LQFSDYYCLL AVHVLIDIWR
     EAGEETAVWQ ALTLLEEGLT HSPSNAQFKL LLVRIYCVLG AFEPVVDLYS SLDAKHIQHD
     TIGYLLTRYA ASLGQYAAAS QSCNFALRFF HSNQKDTSEY IIQAYKYGAF EKIPEFIAFR
     NRLNNSLHFA QVRTERMLLD LLLEANISTS LAESIKSMNL RPEEDDVPWE DLRDNRDLDV
     FFSWDPKDRN VSEEHKKLSL EEETMWLRIR SLTLRLISAL PSLTHPVEPR NSEKTSENGV
     SSRVDVLRLL LQQLEVAVET GKRFIEKEIQ YPFLGPVPTR MGRFFSSGCC QCQVHSFHLV
     SDVYELDTSG LEGTVDIQER IENSLASLLE LLKGVFSTCK GDLLEVKDGN VKTQPAVLEN
     LVFFVETISI VLWVSSYCES VLRPYKLNIQ KKKKKKKETS IVMPPIFTSF QDYVTGLQTV
     ISNAVDHIKG LEAHLIALKL EELTLEDTSI SPVNLSNCHV LSVRRRDPGS YWKLGAVEPM
     CADVCPSVQI
 
 
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