NAA25_RAT
ID NAA25_RAT Reviewed; 970 AA.
AC Q6QI44;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=N-alpha-acetyltransferase 25, NatB auxiliary subunit;
DE AltName: Full=Liver regeneration-related protein LRRGT00164;
DE AltName: Full=Mitochondrial distribution and morphology protein 20;
DE AltName: Full=N-terminal acetyltransferase B complex subunit MDM20;
DE Short=NatB complex subunit MDM20;
DE AltName: Full=N-terminal acetyltransferase B complex subunit NAA25;
GN Name=Naa25; Synonyms=Mdm20;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Xu C.S., Zhang L., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y.,
RA Yang K.J., Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M.,
RA Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT "Liver regeneration after PH.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Non-catalytic subunit of the NatB complex which catalyzes
CC acetylation of the N-terminal methionine residues of peptides beginning
CC with Met-Asp-Glu. May play a role in normal cell-cycle progression.
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the N-terminal acetyltransferase B (NatB) complex
CC which is composed of NAA20 and NAA25. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MDM20/NAA25 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY539915; AAS66255.1; -; mRNA.
DR RefSeq; NP_001041365.1; NM_001047900.1.
DR AlphaFoldDB; Q6QI44; -.
DR SMR; Q6QI44; -.
DR STRING; 10116.ENSRNOP00000049175; -.
DR PhosphoSitePlus; Q6QI44; -.
DR jPOST; Q6QI44; -.
DR PaxDb; Q6QI44; -.
DR PRIDE; Q6QI44; -.
DR Ensembl; ENSRNOT00000048984; ENSRNOP00000049175; ENSRNOG00000001350.
DR GeneID; 360811; -.
DR KEGG; rno:360811; -.
DR CTD; 80018; -.
DR RGD; 1305685; Naa25.
DR eggNOG; KOG2053; Eukaryota.
DR GeneTree; ENSGT00950000183174; -.
DR InParanoid; Q6QI44; -.
DR PhylomeDB; Q6QI44; -.
DR PRO; PR:Q6QI44; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Bgee; ENSRNOG00000001350; Expressed in skeletal muscle tissue and 20 other tissues.
DR ExpressionAtlas; Q6QI44; baseline and differential.
DR Genevisible; Q6QI44; RN.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0031416; C:NatB complex; IBA:GO_Central.
DR GO; GO:0017196; P:N-terminal peptidyl-methionine acetylation; IBA:GO_Central.
DR InterPro; IPR019183; N-acetylTrfase_B_cplx_non-cat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR22767:SF3; PTHR22767:SF3; 1.
DR Pfam; PF09797; NatB_MDM20; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..970
FT /note="N-alpha-acetyltransferase 25, NatB auxiliary
FT subunit"
FT /id="PRO_0000294339"
FT REPEAT 11..44
FT /note="TPR 1"
FT REPEAT 45..78
FT /note="TPR 2"
FT REPEAT 79..112
FT /note="TPR 3"
FT REPEAT 114..146
FT /note="TPR 4"
SQ SEQUENCE 970 AA; 111258 MW; E55DA4DFBD2B88B4 CRC64;
MATRGHVQDP NDRRLRPIYD YLDNGNNKMA IQQADKLLKK HRDLHCAKVL KAIGLQRTGR
QEEAFTLAQE VAALEPTDDN SLQALTILYR EMHRPELVTK LYEAAVKKVP NSEEYHSHLF
MAYARVGEYK KMQQAGMALY KIVPKNPYYF WSVMSLIMQS ISARDENLSK TMFLPLAERM
VEKMVKEDKI EAEAEVELYY MILERLGKYQ EALDVIRGKL GEKLTSEIQS RENKCMAMYK
KLSKWPECNA LSRRLLLKNS DDWQFYLTYF DSVFRLIEEA WTPPAEGEHS LEGEVHCSAE
DAVKFIEDRI TEASQSSRHV RGPHLAKLEL IRRLRSQGCN DEFRLGDPEE LMFQYFKKFG
DKPCCFTDLK VFVDLLPAAQ CTQFINQLLG VVPLSTPTED KLALPADIRG LQQHLCVVQL
TRLLGLYHSM DKNQKLDVVR ELMLRYQHGL EFGRSCLKTE LQFSDYYCLL AVHVLIDIWR
EAGEETAVWQ ALTLLEEGLT HSPSNAQFKL LLVRIYCVLG AFEPVVDLYS SLDAKHIQHD
TIGYLLTRYA ASLGQYAAAS QSCNFALRFF HSNQKDTSEY IIQAYKYGAF EKIPEFIAFR
NRLNNSLHFA QVRTERMLLD LLLEANISTS LAESIKSMNL RPEEDDVPWE DLRDNRDLDV
FFSWDPKDRN VSEEHKKLSL EEETMWLRIR SLTLRLISAL PSLTHPVEPR NSEKTSENGV
SSRVDVLRLL LQQLEVAVET GKRFIEKEIQ YPFLGPVPTR MGRFFSSGCC QCQVHSFHLV
SDVYELDTSG LEGTVDIQER IENSLASLLE LLKGVFSTCK GDLLEVKDGN VKTQPAVLEN
LVFFVETISI VLWVSSYCES VLRPYKLNIQ KKKKKKKETS IVMPPIFTSF QDYVTGLQTV
ISNAVDHIKG LEAHLIALKL EELTLEDTSI SPVNLSNCHV LSVRRRDPGS YWKLGAVEPM
CADVCPSVQI