NAA35_DANRE
ID NAA35_DANRE Reviewed; 724 AA.
AC Q7T322;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=N-alpha-acetyltransferase 35, NatC auxiliary subunit;
DE AltName: Full=Embryonic growth-associated protein;
DE Short=zEGAP;
DE AltName: Full=Protein MAK10 homolog;
GN Name=naa35; Synonyms=egap, mak10;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=16484612; DOI=10.1161/01.res.0000214539.86593.7a;
RA Wenzlau J.M., Garl P.J., Simpson P., Stenmark K.R., West J., Artinger K.B.,
RA Nemenoff R.A., Weiser-Evans M.C.M.;
RT "Embryonic growth-associated protein is one subunit of a novel N-terminal
RT acetyltransferase complex essential for embryonic vascular development.";
RL Circ. Res. 98:846-855(2006).
CC -!- FUNCTION: Auxillary component of the N-terminal acetyltransferase C
CC (NatC) complex which catalyzes acetylation of N-terminal methionine
CC residues. Regulates cell proliferation during embryonic development.
CC May be involved in acetylating the N-terminus of mtor.
CC {ECO:0000269|PubMed:16484612}.
CC -!- SUBUNIT: Component of the N-terminal acetyltransferase C (NatC)
CC complex, which is composed of naa35, naa38 and naa30.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed at high levels at 6 hpf. Expression
CC levels remain high through 18 hpf and 28 hpf in many developing tissues
CC suCh as vascular structures or epidermis. By 48 hpf, expression is
CC restricted to the head. At 5 dpf, expression is restricted to
CC epidermis. {ECO:0000269|PubMed:16484612}.
CC -!- SIMILARITY: Belongs to the MAK10 family. {ECO:0000305}.
CC -!- CAUTION: PubMed:16484612 decribes a naa35/zEgap-containing complex as
CC evolutionary conserved NatC complex; however, the zMak3 protein
CC investigated in this context corresponds to mammalian NAA50 and not
CC NAA30 and its interaction with NAA35 is ambiguous. {ECO:0000305}.
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DR EMBL; BC053286; AAH53286.1; -; mRNA.
DR RefSeq; NP_955844.1; NM_199550.1.
DR AlphaFoldDB; Q7T322; -.
DR SMR; Q7T322; -.
DR STRING; 7955.ENSDARP00000089478; -.
DR PaxDb; Q7T322; -.
DR GeneID; 321587; -.
DR KEGG; dre:321587; -.
DR CTD; 60560; -.
DR ZFIN; ZDB-GENE-030131-306; naa35.
DR eggNOG; KOG2343; Eukaryota.
DR InParanoid; Q7T322; -.
DR OrthoDB; 1370304at2759; -.
DR PhylomeDB; Q7T322; -.
DR BRENDA; 2.3.1.256; 928.
DR PRO; PR:Q7T322; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0031417; C:NatC complex; ISS:UniProtKB.
DR GO; GO:0048514; P:blood vessel morphogenesis; IMP:ZFIN.
DR GO; GO:0017196; P:N-terminal peptidyl-methionine acetylation; IEA:InterPro.
DR GO; GO:0006474; P:N-terminal protein amino acid acetylation; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:ZFIN.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:ZFIN.
DR GO; GO:0032006; P:regulation of TOR signaling; IMP:ZFIN.
DR GO; GO:0048659; P:smooth muscle cell proliferation; ISS:UniProtKB.
DR GO; GO:0001756; P:somitogenesis; IMP:ZFIN.
DR InterPro; IPR007244; Naa35/Mak10.
DR PANTHER; PTHR21373; PTHR21373; 1.
DR Pfam; PF04112; Mak10; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; Reference proteome.
FT CHAIN 1..724
FT /note="N-alpha-acetyltransferase 35, NatC auxiliary
FT subunit"
FT /id="PRO_0000308620"
SQ SEQUENCE 724 AA; 83153 MW; FBA6F44225F04B72 CRC64;
MVMKSSVEEE EGGWGLGIPE KMRNNANWVD VTQEFKGACK ELKLGELLHD KLFGLFEAMS
AIEMMDPKMD AGMIGNQVNR KVLNFDQAVK DEAIRVKDLS IPELIGIMDT CFCCLITWLE
GHSLAQTVFT CLYVHNPDLI QDPALKAFAL GILKICDIAR EKVNKAAVFE EEDFQAMTYG
FKMANNVTDL RVTGMLKDVE DELQRKVKST RSRQGEQRDP EVELDHQQCL ALFSRVKFTR
LLLSALISFT KKETSAVSEA QKLMSQAADL LPAVHATIQY GIQSQNDTTK GDHPIMMGFE
PLVNQRLLPP TFPRYAKIIK REEMVNYFSK LIERIKSVCE VINITNLHSI LDFFCEFSEQ
SPCVLSRSLL QTTFLIDNKK VFGTHLMQDM IKDALRCFVS PPVLSSKCSL NNNHQAKDYI
DSFVTHCTRP FCSLIQIHGH NRARQRDKLG HILEEFATLQ DEAEKVDAAL HGLLMKLEPQ
RQHLACLGTW ILYHNLRIMI QYLLSGFELE LYSMHEYYYI YWYLSEFLYA WLMSTLSRAD
SSQMAEERIL EEQLKVRSSK KSKKKKKARP LSKEITMSQA YQNMCAGMYK TMIALDMDRK
VRKPQFELDS EQVRYEHRFA PFNSVVTPPP VHYIQFKEMS DLKKYNPPPR SADLYMAASK
HFQQAKLLLE NVTSPDAEVN RILKVAKPNI VVMKLLAGGH KKETKALPEF DFSAHKYFPI
VKIL