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NAA35_HUMAN
ID   NAA35_HUMAN             Reviewed;         725 AA.
AC   Q5VZE5; Q5VZE6; Q9H631; Q9H703;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=N-alpha-acetyltransferase 35, NatC auxiliary subunit;
DE   AltName: Full=Embryonic growth-associated protein homolog;
DE   AltName: Full=Protein MAK10 homolog;
GN   Name=NAA35; Synonyms=EGAP, MAK10;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Colon, and Small intestine;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=16484612; DOI=10.1161/01.res.0000214539.86593.7a;
RA   Wenzlau J.M., Garl P.J., Simpson P., Stenmark K.R., West J., Artinger K.B.,
RA   Nemenoff R.A., Weiser-Evans M.C.M.;
RT   "Embryonic growth-associated protein is one subunit of a novel N-terminal
RT   acetyltransferase complex essential for embryonic vascular development.";
RL   Circ. Res. 98:846-855(2006).
RN   [6]
RP   NOMENCLATURE.
RX   PubMed=19660095; DOI=10.1186/1753-6561-3-s6-s2;
RA   Polevoda B., Arnesen T., Sherman F.;
RT   "A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature,
RT   subunits and substrates.";
RL   BMC Proc. 3:S2-S2(2009).
RN   [7]
RP   FUNCTION IN APOPTOSIS, IDENTIFICATION IN NATC COMPLEX, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=19398576; DOI=10.1128/mcb.01909-08;
RA   Starheim K.K., Gromyko D., Evjenth R., Ryningen A., Varhaug J.E.,
RA   Lillehaug J.R., Arnesen T.;
RT   "Knockdown of human N alpha-terminal acetyltransferase complex C leads to
RT   p53-dependent apoptosis and aberrant human Arl8b localization.";
RL   Mol. Cell. Biol. 29:3569-3581(2009).
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [9]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- FUNCTION: Auxillary component of the N-terminal acetyltransferase C
CC       (NatC) complex which catalyzes acetylation of N-terminal methionine
CC       residues. Involved in regulation of apoptosis and proliferation of
CC       smooth muscle cells. {ECO:0000269|PubMed:19398576}.
CC   -!- SUBUNIT: Component of the N-terminal acetyltransferase C (NatC)
CC       complex, which is composed of NAA35, NAA38 and NAA30.
CC       {ECO:0000269|PubMed:19398576}.
CC   -!- INTERACTION:
CC       Q5VZE5; Q147X3: NAA30; NbExp=2; IntAct=EBI-9106478, EBI-9106461;
CC       Q5VZE5; Q9C029: TRIM7; NbExp=3; IntAct=EBI-9106478, EBI-2813981;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19398576}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5VZE5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5VZE5-2; Sequence=VSP_056098, VSP_056099;
CC   -!- SIMILARITY: Belongs to the MAK10 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB15097.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAB15435.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK025266; BAB15097.1; ALT_FRAME; mRNA.
DR   EMBL; AK026296; BAB15435.1; ALT_INIT; mRNA.
DR   EMBL; AK056059; BAG51612.1; -; mRNA.
DR   EMBL; AL161447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL161453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471089; EAW62702.1; -; Genomic_DNA.
DR   EMBL; CH471089; EAW62703.1; -; Genomic_DNA.
DR   EMBL; BC117427; AAI17428.1; -; mRNA.
DR   EMBL; BC117429; AAI17430.1; -; mRNA.
DR   CCDS; CCDS6673.1; -. [Q5VZE5-1]
DR   RefSeq; NP_001308810.1; NM_001321881.1. [Q5VZE5-1]
DR   RefSeq; NP_001308811.1; NM_001321882.1. [Q5VZE5-1]
DR   RefSeq; NP_078911.3; NM_024635.3. [Q5VZE5-1]
DR   RefSeq; XP_005252184.1; XM_005252127.3. [Q5VZE5-1]
DR   AlphaFoldDB; Q5VZE5; -.
DR   SMR; Q5VZE5; -.
DR   BioGRID; 121941; 32.
DR   ComplexPortal; CPX-6275; NatC N-alpha-acetyltransferase complex.
DR   IntAct; Q5VZE5; 5.
DR   STRING; 9606.ENSP00000354972; -.
DR   iPTMnet; Q5VZE5; -.
DR   MetOSite; Q5VZE5; -.
DR   PhosphoSitePlus; Q5VZE5; -.
DR   BioMuta; NAA35; -.
DR   DMDM; 74747795; -.
DR   EPD; Q5VZE5; -.
DR   jPOST; Q5VZE5; -.
DR   MassIVE; Q5VZE5; -.
DR   MaxQB; Q5VZE5; -.
DR   PaxDb; Q5VZE5; -.
DR   PeptideAtlas; Q5VZE5; -.
DR   PRIDE; Q5VZE5; -.
DR   ProteomicsDB; 65692; -. [Q5VZE5-1]
DR   ProteomicsDB; 65693; -.
DR   Antibodypedia; 13206; 102 antibodies from 21 providers.
DR   DNASU; 60560; -.
DR   Ensembl; ENST00000361671.10; ENSP00000354972.5; ENSG00000135040.16. [Q5VZE5-1]
DR   Ensembl; ENST00000376040.2; ENSP00000365208.1; ENSG00000135040.16. [Q5VZE5-2]
DR   GeneID; 60560; -.
DR   KEGG; hsa:60560; -.
DR   MANE-Select; ENST00000361671.10; ENSP00000354972.5; NM_024635.4; NP_078911.3.
DR   UCSC; uc004aoi.5; human. [Q5VZE5-1]
DR   CTD; 60560; -.
DR   DisGeNET; 60560; -.
DR   GeneCards; NAA35; -.
DR   HGNC; HGNC:24340; NAA35.
DR   HPA; ENSG00000135040; Low tissue specificity.
DR   MIM; 619438; gene.
DR   neXtProt; NX_Q5VZE5; -.
DR   OpenTargets; ENSG00000135040; -.
DR   PharmGKB; PA165585932; -.
DR   VEuPathDB; HostDB:ENSG00000135040; -.
DR   eggNOG; KOG2343; Eukaryota.
DR   GeneTree; ENSGT00390000002445; -.
DR   HOGENOM; CLU_011757_1_1_1; -.
DR   InParanoid; Q5VZE5; -.
DR   OMA; ACLNRCR; -.
DR   OrthoDB; 1370304at2759; -.
DR   PhylomeDB; Q5VZE5; -.
DR   TreeFam; TF320627; -.
DR   BioCyc; MetaCyc:ENSG00000135040-MON; -.
DR   PathwayCommons; Q5VZE5; -.
DR   Reactome; R-HSA-6811440; Retrograde transport at the Trans-Golgi-Network.
DR   SignaLink; Q5VZE5; -.
DR   SIGNOR; Q5VZE5; -.
DR   BioGRID-ORCS; 60560; 317 hits in 1093 CRISPR screens.
DR   ChiTaRS; NAA35; human.
DR   GenomeRNAi; 60560; -.
DR   Pharos; Q5VZE5; Tbio.
DR   PRO; PR:Q5VZE5; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q5VZE5; protein.
DR   Bgee; ENSG00000135040; Expressed in secondary oocyte and 208 other tissues.
DR   Genevisible; Q5VZE5; HS.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0031417; C:NatC complex; IDA:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0017196; P:N-terminal peptidyl-methionine acetylation; IC:ComplexPortal.
DR   GO; GO:0006474; P:N-terminal protein amino acid acetylation; IBA:GO_Central.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
DR   GO; GO:0048659; P:smooth muscle cell proliferation; ISS:UniProtKB.
DR   InterPro; IPR007244; Naa35/Mak10.
DR   PANTHER; PTHR21373; PTHR21373; 1.
DR   Pfam; PF04112; Mak10; 2.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..725
FT                   /note="N-alpha-acetyltransferase 35, NatC auxiliary
FT                   subunit"
FT                   /id="PRO_0000308614"
FT   REGION          548..573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         187
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VAR_SEQ         293..294
FT                   /note="DH -> GL (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056098"
FT   VAR_SEQ         295..725
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056099"
FT   CONFLICT        229
FT                   /note="Q -> R (in Ref. 1; BAB15097)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        487
FT                   /note="C -> W (in Ref. 1; BAB15097)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   725 AA;  83639 MW;  A5612BA0CE1BAE3F CRC64;
     MVMKASVDDD DSGWELSMPE KMEKSNTNWV DITQDFEEAC RELKLGELLH DKLFGLFEAM
     SAIEMMDPKM DAGMIGNQVN RKVLNFEQAI KDGTIKIKDL TLPELIGIMD TCFCCLITWL
     EGHSLAQTVF TCLYIHNPDF IEDPAMKAFA LGILKICDIA REKVNKAAVF EEEDFQSMTY
     GFKMANSVTD LRVTGMLKDV EDDMQRRVKS TRSRQGEERD PEVELEHQQC LAVFSRVKFT
     RVLLTVLIAF TKKETSAVAE AQKLMVQAAD LLSAIHNSLH HGIQAQNDTT KGDHPIMMGF
     EPLVNQRLLP PTFPRYAKII KREEMVNYFA RLIDRIKTVC EVVNLTNLHC ILDFFCEFSE
     QSPCVLSRSL LQTTFLVDNK KVFGTHLMQD MVKDALRSFV SPPVLSPKCY LYNNHQAKDC
     IDSFVTHCVR PFCSLIQIHG HNRARQRDKL GHILEEFATL QDEAEKVDAA LHTMLLKQEP
     QRQHLACLGT WVLYHNLRIM IQYLLSGFEL ELYSMHEYYY IYWYLSEFLY AWLMSTLSRA
     DGSQMAEERI MEEQQKGRSS KKTKKKKKVR PLSREITMSQ AYQNMCAGMF KTMVAFDMDG
     KVRKPKFELD SEQVRYEHRF APFNSVMTPP PVHYLQFKEM SDLNKYSPPP QSPELYVAAS
     KHFQQAKMIL ENIPNPDHEV NRILKVAKPN FVVMKLLAGG HKKESKVPPE FDFSAHKYFP
     VVKLV
 
 
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