ID   NAA35_MACFA             Reviewed;         725 AA.
AC   Q4R708;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=N-alpha-acetyltransferase 35, NatC auxiliary subunit;
DE   AltName: Full=Protein MAK10 homolog;
GN   Name=NAA35; Synonyms=MAK10; ORFNames=QtsA-16666;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Auxillary component of the N-terminal acetyltransferase C
CC       (NatC) complex which catalyzes acetylation of N-terminal methionine
CC       residues. Involved in regulation of apoptosis and proliferation of
CC       smooth muscle cells.
CC   -!- SUBUNIT: Component of the N-terminal acetyltransferase C (NatC)
CC       complex, which is composed of NAA35, NAA38 and NAA30.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MAK10 family. {ECO:0000305}.
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DR   EMBL; AB169022; BAE01116.1; -; mRNA.
DR   RefSeq; NP_001274610.1; NM_001287681.1.
DR   RefSeq; XP_005582114.1; XM_005582057.2.
DR   RefSeq; XP_005582115.1; XM_005582058.2.
DR   RefSeq; XP_005582116.1; XM_005582059.2.
DR   RefSeq; XP_005582117.1; XM_005582060.2.
DR   RefSeq; XP_005582118.1; XM_005582061.2.
DR   AlphaFoldDB; Q4R708; -.
DR   SMR; Q4R708; -.
DR   STRING; 9541.XP_005582113.1; -.
DR   PRIDE; Q4R708; -.
DR   Ensembl; ENSMFAT00000003505; ENSMFAP00000029309; ENSMFAG00000041931.
DR   GeneID; 102137023; -.
DR   KEGG; mcf:102137023; -.
DR   CTD; 60560; -.
DR   VEuPathDB; HostDB:ENSMFAG00000041931; -.
DR   eggNOG; KOG2343; Eukaryota.
DR   GeneTree; ENSGT00390000002445; -.
DR   OrthoDB; 1370304at2759; -.
DR   Proteomes; UP000233100; Chromosome 15.
DR   Bgee; ENSMFAG00000041931; Expressed in heart and 13 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0031417; C:NatC complex; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005844; C:polysome; IEA:Ensembl.
DR   GO; GO:0017196; P:N-terminal peptidyl-methionine acetylation; IEA:InterPro.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:0048659; P:smooth muscle cell proliferation; ISS:UniProtKB.
DR   InterPro; IPR007244; Naa35/Mak10.
DR   PANTHER; PTHR21373; PTHR21373; 1.
DR   Pfam; PF04112; Mak10; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..725
FT                   /note="N-alpha-acetyltransferase 35, NatC auxiliary
FT                   subunit"
FT                   /id="PRO_0000308615"
FT   REGION          548..573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         187
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5VZE5"
SQ   SEQUENCE   725 AA;  83612 MW;  3723D394FCD46E03 CRC64;
     MVMKASVDDD DSGWELSMPE KMEKSNTNWV DITQDFEEAC RELKLGELLH DKLFGLFEAM
     SAIEMMDPKM DAGMIGNQVN RKVLNFEQAI KDGTIKIKDL TLPELIGIMD TCFCCLITWL
     EGHSLAQTVF TCLYIHNPDF IEDPAMKAFA LGILKICDIA REKVNKAAVF EEEDFQSMTY
     GFKMANSVTD LRVTGMLKDV EDDMQRRVKS TRSRQGEERD PEVELEHQQC LAVFSRVKFT
     RVLLTVLIAF TKKETSAVAE AQKLMVQAAD LLSAIHNSLH HGIQAQNDTT KGDHPIMMGF
     EPLVNQRLLP PTFPRYAKII KREEMVSYFA RLIDRIKTVC EVVNLTNLHC ILDFFCEFSE
     QSPCVLSRSL LQTTFLVDNK KVFGTHLMQD MVKDALRSFV SPPVLSPKCY LYNNHQAKDC
     IDSFVTHCVR PFCSLIQIHG HNRARQRDKL GHILEEFATL QDEAEKVDAA LHTMLLKQEP
     QRQHLACLGT WVLYHNLRIM IQYLLSGFEL ELYSMHEYYY IYWYLSEFLY AWLMSTLSRA
     DGSQMAEERI MEEQQKGRSS KKTKKKKKVR PLSREITMSQ AYQNMCAGMF KTMVAFDMDG
     KVRKPKFELD SEQVRYEHRF APFNSVMTPP PVHYLQFKEM SDLNKYSPPP QSPELYVAAS
     KHFQQAKMIL ENIPNPDHEV NRILKVAKPN FVVMKLLAGG HKKESKVPPE FDFSAHKYFP
     VVKLV