NAA35_RAT
ID NAA35_RAT Reviewed; 725 AA.
AC Q6DKG0; Q9JI01;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=N-alpha-acetyltransferase 35, NatC auxiliary subunit;
DE AltName: Full=Corneal wound-healing-related protein;
DE AltName: Full=Embryonic growth-associated protein;
DE AltName: Full=Protein MAK10 homolog;
GN Name=Naa35; Synonyms=Egap, Emb8, Mak10;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, INDUCTION, TISSUE
RP SPECIFICITY, AND FUNCTION IN CELL PROLIFERATION.
RX PubMed=11009567; DOI=10.1161/01.res.87.7.608;
RA Weiser-Evans M.C.M., Schwartz P.E., Grieshaber N.A., Quinn B.E.,
RA Grieshaber S.S., Belknap J.K., Mourani P.M., Majack R.A., Stenmark K.R.;
RT "Novel embryonic genes are preferentially expressed by autonomously
RT replicating rat embryonic and neointimal smooth muscle cells.";
RL Circ. Res. 87:608-615(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10855038; DOI=10.1076/0271-3683(200005)2051-1ft430;
RA Yi X.J., Li X.F., Yu F.S.;
RT "A novel epithelial wound-related gene is abundantly expressed in
RT developing rat cornea and skin.";
RL Curr. Eye Res. 20:430-440(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION.
RX PubMed=16484612; DOI=10.1161/01.res.0000214539.86593.7a;
RA Wenzlau J.M., Garl P.J., Simpson P., Stenmark K.R., West J., Artinger K.B.,
RA Nemenoff R.A., Weiser-Evans M.C.M.;
RT "Embryonic growth-associated protein is one subunit of a novel N-terminal
RT acetyltransferase complex essential for embryonic vascular development.";
RL Circ. Res. 98:846-855(2006).
CC -!- FUNCTION: Auxillary component of the N-terminal acetyltransferase C
CC (NatC) complex which catalyzes acetylation of N-terminal methionine
CC residues. Involved in regulation of apoptosis and proliferation of
CC smooth muscle cells. {ECO:0000269|PubMed:11009567,
CC ECO:0000269|PubMed:16484612}.
CC -!- SUBUNIT: Component of the N-terminal acetyltransferase C (NatC)
CC complex, which is composed of NAA35, NAA38 and NAA30. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in primary spermatocytes, basal
CC epidermis, interstitial fibroblasts of skeletal muscle, and intestinal
CC crypts. {ECO:0000269|PubMed:11009567}.
CC -!- DEVELOPMENTAL STAGE: Widely expressed in the embryo. Expressed in
CC embryonic aorta and pulmonary arteries from E12 to E19.
CC {ECO:0000269|PubMed:11009567}.
CC -!- INDUCTION: In carotid arteries, after mechanic injury.
CC {ECO:0000269|PubMed:11009567}.
CC -!- SIMILARITY: Belongs to the MAK10 family. {ECO:0000305}.
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DR EMBL; AF272892; AAF81791.1; -; mRNA.
DR EMBL; BC074005; AAH74005.1; -; mRNA.
DR RefSeq; NP_579858.1; NM_133324.1.
DR RefSeq; XP_006253588.1; XM_006253526.3.
DR AlphaFoldDB; Q6DKG0; -.
DR SMR; Q6DKG0; -.
DR STRING; 10116.ENSRNOP00000025096; -.
DR jPOST; Q6DKG0; -.
DR PaxDb; Q6DKG0; -.
DR GeneID; 64472; -.
DR KEGG; rno:64472; -.
DR UCSC; RGD:621771; rat.
DR CTD; 60560; -.
DR RGD; 621771; Naa35.
DR VEuPathDB; HostDB:ENSRNOG00000018417; -.
DR eggNOG; KOG2343; Eukaryota.
DR HOGENOM; CLU_011757_1_1_1; -.
DR InParanoid; Q6DKG0; -.
DR OMA; ACLNRCR; -.
DR OrthoDB; 1370304at2759; -.
DR PhylomeDB; Q6DKG0; -.
DR TreeFam; TF320627; -.
DR PRO; PR:Q6DKG0; -.
DR Proteomes; UP000002494; Chromosome 17.
DR Bgee; ENSRNOG00000018417; Expressed in skeletal muscle tissue and 20 other tissues.
DR Genevisible; Q6DKG0; RN.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0031417; C:NatC complex; ISS:UniProtKB.
DR GO; GO:0017196; P:N-terminal peptidyl-methionine acetylation; IEA:InterPro.
DR GO; GO:0006474; P:N-terminal protein amino acid acetylation; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0048659; P:smooth muscle cell proliferation; ISS:UniProtKB.
DR InterPro; IPR007244; Naa35/Mak10.
DR PANTHER; PTHR21373; PTHR21373; 1.
DR Pfam; PF04112; Mak10; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..725
FT /note="N-alpha-acetyltransferase 35, NatC auxiliary
FT subunit"
FT /id="PRO_0000308618"
FT REGION 548..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 169
FT /note="V -> A (in Ref. 2; AAF81791)"
FT /evidence="ECO:0000305"
FT CONFLICT 396
FT /note="L -> P (in Ref. 2; AAF81791)"
FT /evidence="ECO:0000305"
FT CONFLICT 509
FT /note="E -> D (in Ref. 2; AAF81791)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 725 AA; 83210 MW; 62B08A63C05CD288 CRC64;
MVMKAAVDDD ASGWELNVPE KMEKSSTSWV DITQDFEDAC RELKLGELLH DKLFGLFEAM
SAIEMMDPKM DAGMIGNQVN RKVLNFEQAV KDGTIKIKDL SLPELIGIMD TCFCCLITWL
EGHSLAQTVF TCLYIHNPDF IEDPAMKAFA LGILKICDIA REKVNKAAVF EEEDFQSMTY
GFKMANGVTD LRVTGMLKDV EDDMQRRVKS TRSRQGEERD PEVELEHQQC LAAFSRVKFT
RVLLTVLIAF TKKETSAVAE AQKLMVQAAD LLSAIHTSLH HGIQAQNGTT KGDHPIMMGF
EPLVNQRLLP PTFPRYAKII KREEMVNYFS RLIDRIKTVC EVVNLPNLHC ILDFFCEFSE
QSPCVLSRSL LQTTFLVDNK KVFGTHLMQD MVKDALRSFV SPPVLSPKCC LYNNHQAKDC
IDSFVTHCVR PFCSLVQIHG HNRARQRDKL GHILEEFATL QDEAEKVDAA LHTMLLKQEP
QRQHLACLGT WVLYHSLRIM IQYLLSGFEL ELYSMHEYYY IYWYLSEFLY AWLMSTLSRA
DGSQMAEERI MEEQQKGRSS KKTKKKKKVR PLSREITMSQ AYQNMCAGMF KTMVAFDMDG
KVRKPKFELD SEQVRYEHRF APFNSVMTPP PVHYLQFKEM SDLSKYSPPP QPPELYVAAS
KHFQQAKMIL ESIPNADREV SRILKVAKPN FVVMKLLAGG HKKESKVPPE FDFSVHKYFP
VVKLV
