NAA38_YEAST
ID NAA38_YEAST Reviewed; 88 AA.
AC P23059; D6VR29;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=N-alpha-acetyltransferase 38, NatC auxiliary subunit;
DE AltName: Full=L-A virus GAG protein N-acetyltransferase subunit MAK31;
DE AltName: Full=Maintenance of killer protein 31;
DE AltName: Full=N-terminal acetyltransferase C complex subunit MAK31;
DE Short=NatC complex subunit MAK31;
GN Name=MAK31; Synonyms=NAA38; OrderedLocusNames=YCR020C-A; ORFNames=YCR20C-A;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3916862; DOI=10.1002/yea.320010204;
RA Toh-e A., Sahashi Y.;
RT "The PET18 locus of Saccharomyces cerevisiae: a complex locus containing
RT multiple genes.";
RL Yeast 1:159-171(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1574125; DOI=10.1038/357038a0;
RA Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA Sgouros J.G.;
RT "The complete DNA sequence of yeast chromosome III.";
RL Nature 357:38-46(1992).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP IDENTIFICATION IN THE NATC COMPLEX, AND FUNCTION OF THE NATC COMPLEX.
RX PubMed=11274203; DOI=10.1074/jbc.m011440200;
RA Polevoda B., Sherman F.;
RT "NatC Nalpha-terminal acetyltransferase of yeast contains three subunits,
RT Mak3p, Mak10p, and Mak31p.";
RL J. Biol. Chem. 276:20154-20159(2001).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Component of the NatC N-terminal acetyltransferase, which
CC catalyzes acetylation of the N-terminus Met of L-A virus Gag protein.
CC MAK31 is necessary for the structural stability of L-A double-stranded
CC RNA-containing particles. Necessary for growth at 37 degrees Celsius as
CC well as for maintenance of the killer plasmid.
CC {ECO:0000269|PubMed:11274203}.
CC -!- SUBUNIT: Component of the N-terminal acetyltransferase C (NatC)
CC complex, which is composed of MAK3, MAK10 and MAK31.
CC {ECO:0000269|PubMed:11274203}.
CC -!- MISCELLANEOUS: Present with 2140 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; X59720; CAA42312.1; -; Genomic_DNA.
DR EMBL; AY558148; AAS56474.1; -; Genomic_DNA.
DR EMBL; BK006937; DAA07498.1; -; Genomic_DNA.
DR PIR; S07694; BVBYK1.
DR RefSeq; NP_009948.1; NM_001178734.1.
DR PDB; 6YGA; X-ray; 2.40 A; C=1-77.
DR PDB; 6YGB; X-ray; 2.45 A; C=1-77.
DR PDB; 6YGC; X-ray; 2.99 A; C=1-77.
DR PDB; 6YGD; X-ray; 2.75 A; C=1-77.
DR PDBsum; 6YGA; -.
DR PDBsum; 6YGB; -.
DR PDBsum; 6YGC; -.
DR PDBsum; 6YGD; -.
DR AlphaFoldDB; P23059; -.
DR SMR; P23059; -.
DR BioGRID; 31002; 135.
DR ComplexPortal; CPX-781; NatC N-alpha-acetyltransferase complex.
DR DIP; DIP-1429N; -.
DR IntAct; P23059; 6.
DR MINT; P23059; -.
DR STRING; 4932.YCR020C-A; -.
DR iPTMnet; P23059; -.
DR MaxQB; P23059; -.
DR PaxDb; P23059; -.
DR PRIDE; P23059; -.
DR EnsemblFungi; YCR020C-A_mRNA; YCR020C-A; YCR020C-A.
DR GeneID; 850383; -.
DR KEGG; sce:YCR020C-A; -.
DR SGD; S000000614; MAK31.
DR VEuPathDB; FungiDB:YCR020C-A; -.
DR eggNOG; ENOG502SDEV; Eukaryota.
DR HOGENOM; CLU_076902_9_0_1; -.
DR InParanoid; P23059; -.
DR OMA; HANYLLD; -.
DR BioCyc; YEAST:G3O-29336-MON; -.
DR PRO; PR:P23059; -.
DR Proteomes; UP000002311; Chromosome III.
DR RNAct; P23059; protein.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0031417; C:NatC complex; IDA:SGD.
DR GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR GO; GO:0005688; C:U6 snRNP; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0006474; P:N-terminal protein amino acid acetylation; IMP:SGD.
DR GO; GO:0016070; P:RNA metabolic process; IBA:GO_Central.
DR CDD; cd06168; LSMD1; 1.
DR InterPro; IPR001163; LSM_dom_euk/arc.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR034110; LSMD1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..88
FT /note="N-alpha-acetyltransferase 38, NatC auxiliary
FT subunit"
FT /id="PRO_0000084554"
FT HELIX 6..8
FT /evidence="ECO:0007829|PDB:6YGA"
FT TURN 9..11
FT /evidence="ECO:0007829|PDB:6YGA"
FT STRAND 12..21
FT /evidence="ECO:0007829|PDB:6YGA"
FT STRAND 23..32
FT /evidence="ECO:0007829|PDB:6YGA"
FT STRAND 37..46
FT /evidence="ECO:0007829|PDB:6YGA"
FT STRAND 49..58
FT /evidence="ECO:0007829|PDB:6YGA"
FT TURN 60..62
FT /evidence="ECO:0007829|PDB:6YGA"
FT STRAND 63..69
FT /evidence="ECO:0007829|PDB:6YGA"
FT HELIX 70..76
FT /evidence="ECO:0007829|PDB:6YGA"
SQ SEQUENCE 88 AA; 9725 MW; 7CA549C9B3919255 CRC64;
MDILKLSDFI GNTLIVSLTE DRILVGSLVA VDAQMNLLLD HVEERMGSSS RMMGLVSVPR
RSVKTIMIDK PVLQELTANK VELMANIV
