NAAT1_DROAN
ID NAAT1_DROAN Reviewed; 640 AA.
AC B3MRS1;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000250|UniProtKB:Q9W4C5};
GN Name=NAAT1 {ECO:0000250|UniProtKB:Q9W4C5}; ORFNames=GF20945;
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217;
RN [1] {ECO:0000312|EMBL:EDV34476.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000312|EMBL:EDV34476.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000305}.
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DR EMBL; CH902622; EDV34476.1; -; Genomic_DNA.
DR RefSeq; XP_001964027.1; XM_001963991.2.
DR AlphaFoldDB; B3MRS1; -.
DR SMR; B3MRS1; -.
DR STRING; 7217.FBpp0124137; -.
DR EnsemblMetazoa; FBtr0125645; FBpp0124137; FBgn0097950.
DR GeneID; 6503636; -.
DR KEGG; dan:6503636; -.
DR eggNOG; KOG3660; Eukaryota.
DR HOGENOM; CLU_006855_9_5_1; -.
DR InParanoid; B3MRS1; -.
DR OMA; WIYGLQN; -.
DR OrthoDB; 250396at2759; -.
DR PhylomeDB; B3MRS1; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0005887; C:integral component of plasma membrane; IC:UniProtKB.
DR GO; GO:0005283; F:amino acid:sodium symporter activity; ISS:UniProtKB.
DR GO; GO:0042943; F:D-amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:EnsemblMetazoa.
DR GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0042940; P:D-amino acid transport; ISS:UniProtKB.
DR GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616; PTHR11616; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SSF161070; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..640
FT /note="Sodium-dependent nutrient amino acid transporter 1"
FT /id="PRO_0000386581"
FT TOPO_DOM 1..30
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 473..493
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 551..571
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 174
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 181
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 640 AA; 71617 MW; DD920D539158252B CRC64;
MELKPNGNHN NNNAAEKSED TEKAKAERTN WGNGLEFLMS CISVSVGLGN VWRFPFTAYE
NGGGAFLIPY IIVLFLIGKP MYYLEMIMGQ FTSQGTVKIW SICPGFVGVG YGQAFGTICI
ISYYSSLLAL TLYYLFVSFQ SELPWSFCRE DWQNCVDSRP AEYTENLITG LASNASTLAS
NLTTPFSNRG VSLLADNETV KLQSSSEIYF LDVVIKEKLD ISDGIGSPDW KLTLALLASW
VVIFLVIMRG VKSSGKAAYF LALFPYVVLF VLLIRAVTLE GARDGIIFFL QPQWGELLNP
TVWKNAVVQC FFSLAVGSGP IIMFASYNRF DHGIYRDAMI VTTLDTLTSL LGGITIFAIL
GNLAHNLNIE NIQDVVRSGT GLAFISYPDA ISKFQAVPQL FSVLFFFMLF VLGIGSIVAL
QSTIVTIICD QFKGLKYWKV ALGTSMCGFL MGLVYVTPGG QWILTLVDFY GGTYVVFILA
IFELAGIVWI YGLQNFCDDI EFMCNRRVSL YWRMCWSFFT PVMMIIIFIY SMVTIEPIKY
SELYFPEAGN VAGWLLFGIG AAQFPLWGLW YVSRHREGSF CSSIMASLKP SEKWGPANAE
VKREWQIFKS QKAAQRAVQK ESSKLGFFWR KITNFCGSNI
