NAAT1_DROER
ID NAAT1_DROER Reviewed; 641 AA.
AC B3NV41;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 55.
DE RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000250|UniProtKB:Q9W4C5};
GN Name=NAAT1 {ECO:0000250|UniProtKB:Q9W4C5}; ORFNames=GG18498;
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220;
RN [1] {ECO:0000312|EMBL:EDV45889.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14021-0224.01 {ECO:0000312|EMBL:EDV45889.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000305}.
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DR EMBL; CH954180; EDV45889.1; -; Genomic_DNA.
DR RefSeq; XP_001976962.1; XM_001976926.2.
DR AlphaFoldDB; B3NV41; -.
DR SMR; B3NV41; -.
DR STRING; 7220.FBpp0137044; -.
DR EnsemblMetazoa; FBtr0138552; FBpp0137044; FBgn0110711.
DR GeneID; 6550942; -.
DR KEGG; der:6550942; -.
DR eggNOG; KOG3660; Eukaryota.
DR HOGENOM; CLU_006855_9_5_1; -.
DR OMA; WIYGLQN; -.
DR OrthoDB; 250396at2759; -.
DR PhylomeDB; B3NV41; -.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:0005887; C:integral component of plasma membrane; IC:UniProtKB.
DR GO; GO:0005283; F:amino acid:sodium symporter activity; ISS:UniProtKB.
DR GO; GO:0042943; F:D-amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:EnsemblMetazoa.
DR GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0042940; P:D-amino acid transport; ISS:UniProtKB.
DR GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616; PTHR11616; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SSF161070; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Glycoprotein; Ion transport; Membrane; Sodium;
KW Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..641
FT /note="Sodium-dependent nutrient amino acid transporter 1"
FT /id="PRO_0000386582"
FT TOPO_DOM 1..38
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 474..494
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 516..536
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 552..572
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 641 AA; 71828 MW; B4B2AAAB24CC3019 CRC64;
MELKGVQPSN GSANGNGTTN AASTEKTDAE KHTPERTNWG NGLEFLMSCI SVSVGLGNVW
RFPFTAYENG GGAFLIPYII VLFLIGKPMY YLEMIMGQFT SQGTVKIWSV VPGFVGVGYG
QAFGTICIIS YYSSLLALTL YYLFVSFQSE LPWSYCRDEW TNCVNSRPQE YVDNLLSGVS
LANESARNFS AIGSVANEET EKLQSSSELY FLNVVIKEKL DISDGVGDPD WKLTLALLAA
WVVIFLVIMR GVKSSGKAAY FLALFPYVVL FVLLIRAVTL EGARDGILFF LEPQWGELLN
PTVWKEAVVQ CFFSLAVGSG PIIMFASYNR FDHGIYRDAM IVTTLDTLTS LLGGITIFAI
LGNLAHNLQI ENIRDVVRSG TGLAFISYPD AISKFKAVPQ LFSVLFFFML FVLGIGSIVA
LQSTIVTIIC DQFKGLKYWK VALITSACGF LMGLVYVTPG GQWILTLVDF YGGTYVVFIL
AIFELAGIVW VYGLQNFCDD IEFMCNRRVS LYWRMCWSFF TPVMMIIIFI YSMVTIEPIK
YSELYFPEAA NIAGWLLFAI GAAQFPLWGL WYVSRHPQGT YWKSLKASMK PSERWGPANP
ETRREWVIFK NHKAAQRATQ KDVSKLGFFW RKLTNFCGSN K
