ID   NAAT1_DROGR             Reviewed;         636 AA.
AC   B4JMC1;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 2.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000250|UniProtKB:Q9W4C5};
GN   Name=NAAT1 {ECO:0000250|UniProtKB:Q9W4C5}; ORFNames=GH24359;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1] {ECO:0000312|EMBL:EDV91882.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00 {ECO:0000312|EMBL:EDV91882.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC       cotransporter that promotes absorption of the D isomers of essential
CC       amino acids. Neutral amino acids are the preferred substrates,
CC       especially methionine and phenylalanine (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC       2.A.22) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDV91882.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH916371; EDV91882.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001992175.1; XM_001992139.1.
DR   AlphaFoldDB; B4JMC1; -.
DR   SMR; B4JMC1; -.
DR   STRING; 7222.FBpp0158265; -.
DR   GeneID; 6566079; -.
DR   KEGG; dgr:6566079; -.
DR   eggNOG; KOG3660; Eukaryota.
DR   InParanoid; B4JMC1; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IC:UniProtKB.
DR   GO; GO:0005283; F:amino acid:sodium symporter activity; ISS:UniProtKB.
DR   GO; GO:0042943; F:D-amino acid transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:EnsemblMetazoa.
DR   GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0042940; P:D-amino acid transport; ISS:UniProtKB.
DR   GO; GO:0015804; P:neutral amino acid transport; ISS:UniProtKB.
DR   GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB.
DR   InterPro; IPR000175; Na/ntran_symport.
DR   InterPro; IPR037272; SNS_sf.
DR   PANTHER; PTHR11616; PTHR11616; 1.
DR   Pfam; PF00209; SNF; 1.
DR   PRINTS; PR00176; NANEUSMPORT.
DR   SUPFAM; SSF161070; SSF161070; 1.
DR   PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR   PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Glycoprotein; Ion transport; Membrane;
KW   Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..636
FT                   /note="Sodium-dependent nutrient amino acid transporter 1"
FT                   /id="PRO_0000386583"
FT   TOPO_DOM        1..50
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        397..417
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        436..456
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        469..489
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        511..531
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        547..567
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        184
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   636 AA;  71119 MW;  FE158DAF70976816 CRC64;
     MELKTMPQNG ANNGNPQGNT SNNNNTNDSS NSNSNNNNKT ERTNWSNGLE FLMSCISVSV
     GLGNIWRFPF TAYENGGGAF LIPYIIVLFM IGKPMYYLEM IMGQFTSQGT VKIWSICPSF
     LGVGYGQAFG TICIISYYSS LLALTLYYLA VSFQADLPWS TCRDTWINCV NSRPAEYIET
     MMTNGSSALT RATDTPAKLQ SSSELYFLDV VINEKTDISD GVGNPDWKLT IALFVSWIVI
     FLVIMRGVKS SGKAAYFLAL FPYVVLFTLL GRAVTLEGAV DGIIFFLEPQ WGELLNPTVW
     KEAVVQCFFS LAVGSGPIIM FSSYNRFDHP IYRDAMIVTT LDTLTSLLGG ITIFAILGNL
     AHNLKVENIR DVVRSGTGLA FISYPDAISK FNAVPQLFSA LFFFMLFVLG IGSIVALQST
     IVTIICDQFK WKYWKVALVT SICGFLMGLV YVTPGGQWIL TLVDFYGGTY VVFILAIFEL
     VGIAWIYGVS NFCDDIEFMS NKRVSLYWRA CWLIFTPIMM IVIFIYSMVT ITPIKYSDIY
     FPVAGDVAGW LLFAIGASQF PLWGWWYVHN HRTGSIAKSF VDSLKPSQKW GPADPETRRN
     WLLFKSDLAA KRAVQAKSDK MGFFRQKLYN MCGRST